Does supraphysiologic estradiol level during IVF have any effect on Oocyte/Embryo quality? A sibling embryo cohort analysis of fresh and subsequent frozen embryo transfer.
CONCLUSIONS: Supraphysiologic serum E2 level prior to HCG trigger does not appear to have negative impact on oocyte and embryo quality.
PMID: 30264951 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Variation in caesarean section rates in Cyprus, Italy and Iceland: an analysis of the role of the media.
CONCLUSIONS: Those working in the media have an ethical responsibility to critically examine the impact of high national CS rates, and to report on solutions that could optimize both the safety and the wellbeing of mothers and babies.
PMID: 30264952 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Findings from the Italian Babies Born Better (B3) survey.
CONCLUSIONS: Mothers highly value respectful, skilled and loving care that gives them a strong sense of personal achievement and confidence, and birth environments that support this. There was distinct variation in the percentage of positive comments made across Italian regions.
PMID: 30264953 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
The gonadotropin system, lessons from animal models and clinical cases.
Authors: Szymańska K, Kałafut J, Rivero-Müller A
Abstract
This review article centres upon family of gonadotropin hormones which consists of two pituitary hormones - follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as one non- pituitary hormone - human chorionic gonadotropin (hCG) secreted by placenta, and their receptors. Gonadotropins play an essential role in proper sexual development, puberty, gametogenesis, maintenance of pregnancy and male sexual differentiation during the fetal development. They belong to the family of glycoprotein hormones thus they constitute heterodimeri...
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Gonadotropin-releasing hormone analog therapeutics.
Authors: Newton CL, Riekert C, Millar RP
Abstract
Dysregulation at any level of the Hypothalamic-Pituitary-Gonadal (HPG) axis results in, or aggravates, a number of hormone-dependent diseases such as delayed or precocious puberty, infertility, prostatic and ovarian cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, endometriosis, uterine fibroids, lean body mass, as well as metabolism and cognitive impairment. As gonadotropin-releasing-hormone (GnRH) is an essential regulator of the HPG axis, agonist and antagonist analogs are efficacious in the treatment of these conditions. GnRH analogs a...
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Molecular human reproduction: advancements in clinical and basic research.
Authors: Casarini L
PMID: 30264956 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Molecular and functional insights into gonadotrophin hormone receptor dimerisation and oligomerisation.
Authors: Agwuegbo UC, Jonas KC
Abstract
The gonadotrophin hormones, follicle stimulating hormone and luteinising hormone, are essential for reproduction. They work in concert to control multiple aspects of gonadal function to ultimately produce meiotically competent and fertilisable gametes, provide the optimal endometrial environment and support for implantation and maintain pregnancy via progesterone production throughout the first trimester of pregnancy. These complex and multidimensional functions are mediated via the gonadotrophin hormone receptors, luteinising hormone receptor (LHR) and follicle stim...
Source: Minerva Ginecologica - September 20, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
New insights into maternity care design and delivery. Editorial commentary.
Authors: Downe S
PMID: 30226028 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 20, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
The cAMP/PKA pathway: steroidogenesis of the antral follicular stage.
Authors: Riccetti L, Sperduti S, Lazzaretti C, Casarini L, Simoni M
Abstract
Pituitary gonadotropins, follicle-stimulating (FSH) and luteinizing hormone (LH), promote follicular recruitment and support antral follicle growth, maturation and selection, resulting in ovulation of the dominant follicle. FSH and LH biological functions are mediated by G protein-coupled receptors, FSHR and LHCGR, resulting in the activation of a number of signaling cascades, such as the cAMP/PKA pathway. Some in vitro data are consistent with the dual, proliferative and pro-apoptotic role of cAMP, leaving unanswered questions on...
Source: Minerva Ginecologica - September 1, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Crosstalk between gonadotropins and thyroid axis.
Authors: De Vincentis S, Monzani ML, Brigante G
Abstract
Gonadotropins and thyroid hormones are essential, respectively, for reproduction and metabolism. The classical endocrinological approach is based on the detection of axes that start from the hypothalamus and arrive at the final effector organ, in this case gonads and thyroid. However, several clues suggest that these axes do not work in parallel, but they dialogue with each other. In this article, we review evidences demonstrating crosstalk between gonadotropins and thyroid axis. Firstly, there is an undeniable structural similarity of both hormones ...
Source: Minerva Ginecologica - July 13, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
β-arrestins and biased signalling in gonadotropin receptors.
Authors: De Pascali F, Reiter E
Abstract
Gonadotropin receptors include the follicle stimulating hormone receptor (FSHR) and the luteinizing hormone/choriogonadotropin receptor (LHCGR), both belong to the G protein- coupled receptor (GPCR) superfamily and being essential to reproduction. FSHR is activated by follicle stimulating hormone (FSH) while LHCGR is activated by either luteinizing hormone (LH) or choriogonadotropin (CG). Upon ligand binding, gonadotropin receptors undergo conformational changes that leads to the activation of the heterotrimeric G protein, resulting in the production of different se...
Source: Minerva Ginecologica - July 13, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Update on oogenesis in vitro.
CONCLUSIONS: Over the years, many improvements have been made on ovarian tissue cultures with the future purpose that patients will be provided with a greater number of developmentally competent oocytes for fertility preservation.
PMID: 29999288 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 13, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Programmed cell death in the human ovary.
Authors: Marcozzi S, Rossi V, Salustri A, De Felici M, Klinger FG
Abstract
During woman's reproductive life, only about 400 of primordial follicles will develop into a pre- ovulatory follicle and undergo ovulation, releasing an oocyte available for fertilization. The process of formation and selection of these follicles is complex and involves a multistep process characterized by a balance between survival and death of the oocytes and the surrounding follicular cells. Although the mechanisms underlying such process are not completely clarified yet, it's common idea that they can occur through various types...
Source: Minerva Ginecologica - July 13, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Preoperative and postoperative ultrasound assessment of stress urinary incontinence.
CONCLUSIONSː Ultrasound could be an important step during preoperative and post-operative assessment of patients affected by stress urinary incontinence.
PMID: 29952478 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 29, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Efficacy of an intimate oil solution containing visnadine in women self-reporting sexual symptoms.
Authors: Caputo A, Natoli A, Radice R, Zanardi G, Giacomelli L
PMID: 29952501 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 29, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
