Can unexplained infertility be evaluated by a new immunological four biomarkers panel? A pilot study.
CONCLUSIONS: Further validation studies are needed to prove that there is a correlation between unexplained infertility and immunological disorders screened by the IMMUNOX Panel, nevertheless our data shows that this diagnostic approach may be helpful to predict and to identify women at higher risk of IVF cycles failure.
PMID: 28994562 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
An update on the genetics of pre-eclampsia.
Authors: Agius A, Sultana R, Camenzuli C, Calleja-Agius J, Balzan R
Abstract
Pre-eclampsia is a progressive multisystem disorder that is exclusive to human pregnancy and defined as new hypertension presenting after 20 weeks with significant proteinuria. It is a multifactorial condition with a strong genetic component and several genes have been linked with this disorder. The main players implicated in the pathogenesis of preeclampsia include immune maladaptation, haemodynamics, endothelial function, thrombophilic disorders, oxidative stress and lipid metabolism. All of these mechanisms encompass genetic fa...
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Targeted therapy for ovarian cancer: the rapidly evolving landscape of PARP inhibitor use.
CONCLUSIONS: The landscape of PARP inhibitor use for ovarian cancer is rapidly evolving and PARP inhibitors have become more available as a targeted therapy option for ovarian cancer treatment.
PMID: 28994564 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Morcellation of occulted sarcomas during laparoscopic myomectomy and hystrectomy for patients with large fibroid uterus.
Authors: Tinelli A, Farghaly SA
Abstract
In April 2014, the United States of America Food and Drug Administration (FDA) published a safety communication warning of the risk of an unsuspected uterine sarcoma being morcellated during a laparoscopic procedure, and advised against the use of power morcellation. In November of the same year, this agency stated: 1. Laparoscopic power morcellators are contraindicated for removal of uterine tissue containing suspected fibroids in patients who are peri- or post-menopausal, or are candidates for "en bloc" tissue removal. 2. Laparoscopic power morcellators are contra...
Source: Minerva Ginecologica - October 5, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Menopause and hormone replacement therapy. The 2017 recommendations of the Italian Menopause Society.
Authors: Gambacciani M, Biglia N, Cagnacci A, DI Carlo C, Caruso S, Cicinelli E, DE Leo V, Farris M, Gambera A, Guaschino S, Lanzone A, Paoletti AM, Russo N, Vicariotto F, Villa P, Volpe A
Abstract
In the last decade the risk benefits ratio of HRT has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausel Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause...
Source: Minerva Ginecologica - October 5, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Prognosis and cost-effectiveness of IVF in poor responders according to the Bologna criteria.
Authors: Busnelli A, Somigliana E
Abstract
Poor ovarian response (POR) to controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) is one of the most challenging issue in the field of reproductive medicine. However, even if improving IVF outcome in poor responders (PORs) represents a main priority, the lack of a unique definition of POR has hampered research in this area. In order to overcome this impediment, an ESHRE Campus Workshop was organized in Bologna in 2010 and reached a consensus on the criteria for the diagnosis of POR ('Bologna criteria'). In this review we aimed to estimate t...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
A modern approach to the management of patients candidate to assisted reproductive technologies.
Authors: Venturella R, Vaiarelli A, Lico D, Ubaldi FM, Zullo F, DI Carlo C
Abstract
The growing use of Assisted Reproductive Technologies (ART) and the incorrect information from mass media, determined in the public the wrong idea that the right moment of life for programming a pregnancy can be delayed well beyond the physiological fertile age. Spare and insufficient health authorities' interventions are driven to explain to the general population the reduction of the fertility potential of couples and particularly of women with advancing age. This situation, characterized by more and more women seeking fo...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Optimising preconception health in women of reproductive age.
Authors: Lang AY, Boyle JA, Fitzgerald G, Teede H, Mazza D, Moran LJ, Harrison C
Abstract
There is a growing realisation that efforts to optimise the health of women and reduce the risk of adverse maternal, perinatal and neonatal outcomes during pregnancy should commence in the preconception period. The preconception period (prior to or between pregnancies) provides an opportune time to address reproductive intentions and promote and support wellbeing and healthy behaviour change regardless of pregnancy intention. Research over the last 30 years has explored the influence of a range of preconception risk f...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Gynecological and obstetrical management of rheumatic diseases in reproductive age.
Authors: Pepe F, Stracquadanio M, Privitera A, Ciotta L, DE Luca F
Abstract
The gynecologist's role in the management of rheumatic patients is complex: it includes the prevention of damage caused by drugs, the counseling about contraception to avoid pregnancy while taking teratogen drugs, the scheduling of pregnancy during the quiescent phase of the specific disease, the replacement of teratogen drugs and a competent management of the pregnancy. The task is carried out as part of a multidisciplinary team with particular attention on differential diagnosis between specific complications of pregnancy and the...
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Is pH a vaginal health marker? Phemale study.
CONCLUSIONS: This study confirms the physiological patterns of vaginal pH changes in Spanish women. Any degree of physical activity and the use of contraceptives were associated with lower pH values. The presence of vulvo-vaginal symptoms was related with higher vaginal pH values. Vaginal pH is a marker of vaginal health.
PMID: 28891279 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Pelvic floor evaluation with transperineal ultrasound: a new approach.
Authors: Vellucci F, Regini C, Barbanti C, Luisi S
Abstract
The increased life expectancy, the importance of the prevention in younger age and the role of the pelvic floor disfunction not only in the disease of the third age, but also in the childbearing age, as the influence on the type of delivery, underline the importance of the evaluation of the pelvic floor. The evaluation of pelvic floor is generally clinical, but in the last 2 decades, the use of ultrasound has become a mainstream diagnostic tool in the investigation of female pelvic organ prolapse, urinary and fecal incontinence and defecation diso...
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Does endometriosis influence the age of menopause?
Authors: Ottolina J, Bartiromo L, Viganò P, Makieva S, Schimberni M, Candiani M
Abstract
Endometriosis is an inflammatory disease affecting 7-10% of women throughout their reproductive life. Few data are available regarding the age at menopause of women affected by this disease. Most of the available evidence, although scanty, would indicate that both ovarian surgery for endometriomas and endometriosis "per se" appear to influence age at menopause. Other factors might interfere with the age at menopause of women affected by endometriosis. The purpose of this review is to examine the age at menopause in wo...
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
In vitro maturation in women with polycystic ovaries and high Anti Mullerian Hormone levels: a retrospective study.
Authors: Gunasheela D, Murali R, Menon JG, Hiremath N, Son WY
PMID: 28752726 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 29, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Maternal mortality in the developed world: a review of surveillance methods, levels and causes of maternal deaths during 2006-2010.
This article provides an overview of surveillance methods, levels, and causes of maternal mortality in developed countries (Europe and the United States) during 2006-2010. Accurate identification of maternal deaths is not always possible, and no two countries in the world use the same surveillance methods for maternal mortality. Despite limitations (underestimation, missclassification), routine vital registration systems are the backbone of maternal mortality surveillance systems in developed countries. Enhanced surveillance methods involve linkages between deaths of women of reproductive age and births within the precedin...
Source: Minerva Ginecologica - July 19, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Fertility preservation options in pre-pubertal females: feasibility, safety and outcomes.
Authors: Newton HL, Glaser AW, Picton HM
PMID: 28707851 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 16, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
