Crizotinib Improves Osteoarthritis Symptoms in a ROS1-Fusion Advanced Non–Small Cell Lung Cancer Patient
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Case Reports Source Type: research
Dose-Escalated Stereotactic Body Radiotherapy (SBRT) as a Salvage Treatment for Two Cases with Relapsed Peripheral Lung Cancer After Initial SBRT
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Case Reports Source Type: research
18F-Sodium Fluoride PET–CT for the Assessment of Brain Metastasis from Lung Adenocarcinoma
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Case Reports Source Type: research
A Case of Pulmonary Squamous Cell Carcinoma Revealed Ground Glass Opacity on Computed Tomography
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Image of the Month Source Type: research
Cabazitaxel Versus Topotecan in Patients with Small-Cell Lung Cancer with Progressive Disease During or After First-Line Platinum-Based Chemotherapy
Conclusion: Cabazitaxel, a next-generation taxane, had inferior efficacy when compared with standard-dose topotecan in the treatment of relapsed SCLC. Topotecan remains a suboptimal therapy, and continued efforts to develop improved second-line treatments are warranted. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Nomograms Predict Overall Survival for Patients with Small-Cell Lung Cancer Incorporating Pretreatment Peripheral Blood Markers
Conclusion: The two nomograms incorporating hematological markers could more accurately predict individualized survival probability of SCLC than the existing models. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
A Predictive Model for Lymph Node Involvement with Malignancy on PET/CT in Non–Small-Cell Lung Cancer
Conclusion: Adenocarcinoma histology, higher LN SUVmax, and higher LN risk category independently correlate with nodal involvement with malignancy and may be used in a model to accurately predict the risk of a node’s involvement with malignancy. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Outcomes after Stereotactic Body Radiotherapy versus Limited Resection in Older Patients with Early-Stage Lung Cancer
Background: Limited resection and stereotactic body radiotherapy (SBRT) have emerged as treatment options for older patients with early-stage non–small-cell lung cancer (NSCLC), who are not good candidates for lobectomy.
Methods: We used the Surveillance, Epidemiology and End Results-Medicare registry to identify patients older than 65 years with stage I to II NSCLC and negative lymph nodes treated with SBRT versus limited resection. We fitted a propensity score model predicting the use of SBRT and compared adjusted overall survival of patients treated with SBRT versus limited resection. Secondary analyses stratified the...
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Patterns of Disease Recurrence after SABR for Early Stage Non–Small-Cell Lung Cancer: Optimizing Follow-Up Schedules for Salvage Therapy
Conclusions: Both the timing of LR and persistent risk of SPLC serve as rationale for long-term follow-up using computed tomography scans in patients fit enough to undergo any radical treatment. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Total Lesion Glycolysis in Positron Emission Tomography Can Predict Gefitinib Outcomes in Non–Small-Cell Lung Cancer with Activating EGFR Mutation
Conclusion: TLG can predict PFS and development of gefitinib resistance in EGFR-mutant NSCLC patients treated with first-line gefitinib. Baseline metabolic tumor burdens measured with TLG before first-line gefitinib will be of great help in predicting time to acquired resistance. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer
Conclusions: The reduced expression of CCDC37 and MAP1B associated with COPD likely predisposes these genes to methylation that in turn, may contribute to lung cancer. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Inhibiting MDM2-p53 Interaction Suppresses Tumor Growth in Patient-Derived Non–Small Cell Lung Cancer Xenograft Models
Conclusions: MDM2 small-molecule inhibitor is effective in treating NSCLC tumors with wild-type p53, supporting further clinical investigation as a potential NSCLC therapy. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Folate Receptor–Positive Circulating Tumor Cell Detected by LT-PCR–Based Method as a Diagnostic Biomarker for Non–Small-Cell Lung Cancer
Conclusion: Ligand-targeted PCR technique was feasible and reliable for detecting folate receptor–positive CTCs in patients with NSCLC, and CTC levels could be used as a useful biomarker for the diagnosis of NSCLC. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung
Conclusions: Our data suggest that mucinous adenocarcinoma is typified by (1) frequent KRAS mutations and a growing list of gene fusions, but rare TP53 mutations, (2) a low mutation burden overall, and (3) a recurrence-free survival similar to stage-matched nonmucinous tumors, with recurrences limited to the lungs. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
Crizotinib Associated with Ground-Glass Opacity Predominant Pattern Interstitial Lung Disease: A Retrospective Observational Cohort Study with a Systematic Literature Review
Conclusion: Forty-nine cases of crizotinib-associated ILD have been identified by the systematic review of the literature, including our six cases. Two types of adverse lung reactions may be observed with different presentation, prognosis, and treatment. Their potential mechanisms should be clarified. Nine patients with the less severe form of ILD were safely retreated. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - July 23, 2015 Category: Cancer & Oncology Tags: Original Article Source Type: research
