Histopathologic and Cytogenetic Features of Pulmonary Adenoid Cystic Carcinoma
Conclusions: A MYB rearrangement was identified in 41% of PACC and was 100% specific. FISH studies for MYB may be of diagnostic utility in PACC, particularly on small biopsy specimens. MYB rearrangement in PACC does not seem to be associated with clinical features or prognosis. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic–Phenotypic Correlations to Emerge
Introduction: Little is known about genotypic and phenotypic correlations in undifferentiated large-cell carcinoma (LCC) of the lung.
Methods: Thirty LCC were dissected by unsupervised targeted next generation sequencing analysis for 50 cancer-associated oncogenes and tumor suppressor genes. Cell differentiation lineages were unveiled by using thyroid transcription factor-1 (TTF1) for adenocarcinoma (ADC) and p40 for squamous cell carcinoma (SQC), dichotomizing immunohistochemistry (IHC) results for TTF1 as negative or positive (whatever its extent) and for p40 as negative, positive, or focal (if (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Spatiotemporal T790M Heterogeneity in Individual Patients with EGFR-Mutant Non–Small-Cell Lung Cancer after Acquired Resistance to EGFR-TKI
Conclusions: T790M status in an individual patient can be spatiotemporally heterogeneous because of selective pressure from EGFR-TKI. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
EML4–ALK Fusion Detected by RT-PCR Confers Similar Response to Crizotinib as Detected by FISH in Patients with Advanced Non–Small-Cell Lung Cancer
Conclusions: RT-PCR should be considered as an alternative/supplemental approach to detect ALK fusion oncogene in NSCLC patients who might benefit from crizotinib treatment. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Lung Cancer Risk Prediction Using Common SNPs Located in GWAS-Identified Susceptibility Regions
Introduction: Genome-wide association studies (GWAS) have consistently identified specific lung cancer susceptibility regions. We evaluated the lung cancer–predictive performance of single-nucleotide polymorphisms (SNPs) in these regions.
Methods: Lung cancer cases (N = 778) and controls (N = 1166) were genotyped for 77 SNPs located in GWAS-identified lung cancer susceptibility regions. Variable selection and model development used stepwise logistic regression and decision-tree analyses. In a subset nested in the Pittsburgh Lung Screening Study, change in area under the receiver operator characteristic curve and net recl...
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Identifying Targeted Strategies to Improve Smoking Cessation Support for Cancer Patients
Conclusions: Improving clinician education and developing dedicated resources to provide cessation support were identified as ideal targets to address for improving cessation support for cancer patients. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
The Influence of the Evolution of First-Line Chemotherapy on Steadily Improving Survival in Advanced Non–Small-Cell Lung Cancer Clinical Trials
Over the past three decades, survival in advanced non–small-cell lung cancer (NSCLC) clinical trials has doubled with an increase in 1-year survival from 25% to 50 to 55%. This has been mainly attributed to improvements in systemic therapy. Although modern first-line chemotherapy regimens have more favorable toxicity profiles, a statistically significant improvement in overall survival has not been demonstrated in existing meta-analyses of second-generation versus third-generation combinations. Moreover, pivotal trials demonstrating statistically significant survival superiority of third-generation regimens are consisten...
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: State of the Art: Concise Review Source Type: research
The IASLC Lung Cancer Staging Project: Proposals for the Revision of the M Descriptors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer
Conclusions: In this revision of the TNM classification, cases with pleural/pericardial effusions, contralateral/bilateral lung nodules, contralateral/bilateral pleural nodules, or a combination of multiple of these parameters should continue to be grouped as M1a category. Single metastatic lesions in a single distant organ should be newly designated to the M1b category. Multiple lesions in a single organ or multiple lesions in multiple organs should be reclassified as M1c category. This new division can serve as a first step into providing rational definitions for an oligometastatic disease stage in non–small-cell lung ...
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: State of the Art: Concise Review Source Type: research
Survival After Sublobar Resection Versus Lobectomy for Clinical Stage IA Lung Cancer: Analysis From the National Cancer Database
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: Editorial Source Type: research
In This Issue/Research Watch/News In Brief/News from the IASLC Tobacco Control Committee
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - October 24, 2015 Category: Cancer & Oncology Tags: In This Issue/Research Watch/News In Brief/News from the IASLC Tobacco Control Committee Source Type: research
Next Generation Sequencing Uncovers Potential Genetic Driver Mutations of Malignant Pulmonary Granular Cell Tumor
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - September 26, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
A Case of Atypical Carcinoid: Harboring Variant 3a/b EML4–ALK Rearrangement
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - September 26, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
Amplification of MET in a Patient with Malignant Pleural Mesothelioma
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - September 26, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
Reply to “Prognostic Value of Fluorodeoxyglucose-Positron Emission Tomography”
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - September 26, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
Prognostic Value of FDG Uptake in Stage I Non–Small-Cell Lung Cancer: Fact or Bias?
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - September 26, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
