Lipodermatosclerosis Secondary to Pemetrexed Use
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Case Report Source Type: research
A High-Grade Pleomorphic Sarcoma in Left Atrium
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Image of the Month Source Type: research
Early-Stage Lung Cancer: 40s Anniversary: Erratum
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Erratum Source Type: research
Somatic STK11 and Concomitant STK11/KRAS Mutational Frequency in Stage IV Lung Adenocarcinoma Adrenal Metastases
Abstract: Somatic serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) is a tumor suppressor gene and ranks as the third most frequently mutated gene in lung adenocarcinoma. However, current molecular testing guidelines recommend evaluating for epidermal growth factor receptor mutations and ALK fusions to guide therapy in all patients with advanced stage adenocarcinoma, regardless of gender, race, or smoking history. Identifying alternative “driver” mutations and using actionable targeted pharmacotherapy is a key approach to providing effective individualized medical care. The analytical sensitivity ...
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Brief Reports Source Type: research
Analysis of ERBB Ligand-Induced Resistance Mechanism to Crizotinib by Primary Culture of Lung Adenocarcinoma with EML4-ALK Fusion Gene
Conclusion: Stimulation by ERBB ligands is suggested to be responsible for resistance to crizotinib in this patient. The CTOS method may enable analysis of resistance mechanism for targeted therapy in individual patients. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Brief Reports Source Type: research
Comparison of Locoregional versus Extended Locoregional Radiation Volumes for Patients with Nonmetastatic Gastro-esophageal Junction Carcinomas
Conclusions: Most GEJ cancers can be safely treated without elective inclusion of splenic/porta nodes. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Genome–Wide Hypomethylation and Specific Tumor-Related Gene Hypermethylation are Associated with Esophageal Squamous Cell Carcinoma Outcome
Conclusions: This study demonstrates that epigenetic alterations of a panel of tumor-related genes and the noncoding region LINE-1 can be used as prognostic indicators and help in clinical management of ESCC patients. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Diffuse High Intensity PD–L1 Staining in Thymic Epithelial Tumors
Conclusions: PD-L1 expression was present in all cases of TETs within the epithelial component but only in a minority in the lymphocytic component. TETs stained more intensely for PD-L1 than in controls, and PD-L1high TETs were associated with more aggressive histology and worse prognosis. This study lends rationale to a clinical trial with anti-PD-1/PD-L1 therapy in this rare tumor type. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Targeted Next-Generation Sequencing of Cancer Genes in Advanced Stage Malignant Pleural Mesothelioma: A Retrospective Study
Conclusion: Next-generation sequencing was applied to a relatively large retrospective series of MPM using formalin-fixed, paraffin-embedded archival material. Our results indicate a complex mutational landscape with a higher number of genetic variations in the p53/DNA repair and phosphatidylinositol 3-kinase pathways, some of them with prognostic value. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Phase II Trial of Gefitinib in Combination with Bevacizumab as First-Line Therapy for Advanced Non–Small Cell Lung Cancer with Activating EGFR Gene Mutations: The Okayama Lung Cancer Study Group Trial 1001
Conclusion: Gefitinib in combination with bevacizumab as first-line therapy seems to be a favorable and well-tolerated treatment for patients with advanced NSCLC with activating EGFR gene mutations, especially those with EGFR exon 19 deletion mutations, although the primary end point was not met because the lower limit of the CI was less than 40%. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Atypical Carcinoid Tumor of the Lung: A Surveillance, Epidemiology, and End Results Database Analysis
Conclusions: AC accounted for less than 1% of all lung cancers diagnosed and was more frequent in women. The best outcomes were observed with surgical resection for localized disease. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Computed Tomography Characteristics Predictive for Radial EBUS-Miniprobe-Guided Diagnosis of Pulmonary Lesions
Conclusion: Multivariate analysis revealed that lesion size, distance to carina, and segment were predictors of diagnostic yield. The presence of a bronchus sign substantially increased the diagnostic yield through the visualization yield. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Postoperative Radiotherapy is Associated with Better Survival in Non–Small Cell Lung Cancer with Involved N2 Lymph Nodes: Results of an Analysis of the National Cancer Data Base
Conclusions: PORT was associated with better survival for patients with pN2 nodes also treated with chemotherapy. No interaction was seen between benefit of PORT and number of involved nodes. These findings reinforce the benefit of PORT for N2 disease in modern practice using the largest, most recent cohort of chemotherapy-treated pN2 patients to date. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Stereotactic Body Radiotherapy for Lung Cancer: How Much Does it Really Cost?
Conclusions: Time-driven activity-based costing of radiotherapy is feasible in a multicentre setup, resulting in real-life resource costs that can form the basis for correct reimbursement schemes, supporting an early yet controlled introduction of innovative radiotherapy techniques in clinical practice. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
MiR-205 and MiR-375 MicroRNA Assays to Distinguish Squamous Cell Carcinoma from Adenocarcinoma in Lung Cancer Biopsies
Conclusions: Histotypic microRNA assays can aid the subtyping of NSCLC biopsies as AC or SCC by standard histopathologic methods. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
