PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non–Small-Cell Lung Cancer
Conclusions: PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post–first-line setting. Further research is warranted to determine the potential value of this marker in clinical decision-making. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Brief Reports Source Type: research
Role of Postoperative Radiotherapy in Nonlocalized Thymoma: Propensity-Matched Analysis of Surveillance, Epidemiology, and End Results Database
Conclusion: Regarding the independent prognostic significance of PORT, this population-based analysis demonstrates the survival benefits of PORT in relation to nonlocalized thymomas. We recommend consideration of PORT in the poor prognostic subset of stages III to IV in the contemporary era. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Perioperative versus Preoperative Chemotherapy with Surgery in Patients with Resectable Squamous Cell Carcinoma of Esophagus: A Phase III Randomized Trial
Conclusion: In patients with operable esophageal squamous cell carcinoma, perioperative regimen of PCF can significantly improve 5-year relapse-free and overall survival comparing with preoperative chemotherapy alone. (The trial has been registered at ClinicalTrials.gov , number NCT01225523.) (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Risk Stratification Model for Resected Squamous-Cell Lung Cancer Patients According to Clinical and Pathological Factors
Conclusions: A risk stratification model including often adopted clinicopathological parameters accurately separates resected squamous-cell lung cancer patients into different risk classes. The project is currently ongoing to integrate the clinicopathological model with investigational molecular predictors. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
High-Grade Neuroendocrine Carcinoma with Bronchial Intraepithelial Tumor Spread: Possibly a New Histologic Feature of Large-Cell Neuroendocrine Carcinoma
Conclusion: The results of this study suggest that bronchial intraepithelial tumor spread is commonly observed in cases of peripherally located HGNEC and may be a unique form of tumor invasion, especially tumors with LCNEC morphology. Therefore, surgeons and pathologists should be cognizant of bronchial intraepithelial tumor spread in peripherally located HGNEC, as well as its potential role as an indicator of HGNEC aggressiveness. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Prognostic Factors of Survival after Recurrence in Patients with Resected Lung Adenocarcinoma
Conclusions: In lung adenocarcinoma, micropapillary/solid predominant pattern group (versus acinar/papillary) was a significant poor prognostic factor for PRS. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Safety and Efficacy of Buparlisib (BKM120) in Patients with PI3K Pathway-Activated Non-Small Cell Lung Cancer: Results from the Phase II BASALT-1 Study
Conclusions: Despite preselecting patients for targeted treatment, BASALT-1 did not meet its primary objective during Stage 1. PI3K pathway activation can be detected using ctDNA, but may not be the main oncogenic driver in NSCLC. Combinations of PI3K inhibitors with other agents may demonstrate greater efficacy than monotherapy. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Early Detection of Lung Cancer with Meso Tetra (4-Carboxyphenyl) Porphyrin-Labeled Sputum
Conclusions: The tetra (4-carboxyphenyl) porphyrin -based CyPath assay correctly classified study participants into cancer or high-risk cohorts with considerable accuracy. Optimizing sputum collection, sample reading, and refining the classifier should improve sensitivity and specificity. The CyPath assay thus has the potential to complement LDCT screening or serve as a stand-alone approach for early lung cancer detection. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Prognostic Impact of Immune Microenvironment in Lung Squamous Cell Carcinoma: Tumor-Infiltrating CD10+ Neutrophil/CD20+ Lymphocyte Ratio as an Independent Prognostic Factor
Conclusion: High CD10+/low CD20+ immune cell infiltration ratio is a significant prognostic factor of lung squamous cell carcinoma. Immunomodulatory therapy of tumor-specific neutrophil and B-lymphocyte responses may have applicability in the treatment of lung squamous cell carcinoma. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor
Conclusion: Actionable driver events can be detected in two thirds of lung adenocarcinoma. MET DNA alterations define a subset of patients with aggressive diseases that might potentially benefit from anti-MET targeted therapy. High negative predictive values of thyroid transcription factor-1 and MET expression suggest potential roles as surrogate markers for EGFR and/or MET mutations. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Should Never-Smokers at Increased Risk for Lung Cancer Be Screened?
Conclusions: Never-smokers with RRs of 15 to 35 have similar to better trade-offs between benefits and harms compared with ever-smokers recommended for lung cancer screening by the USPSTF guidelines. For most never-smokers, lung cancer screening is not beneficial. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Alpha-1 Antitrypsin Deficiency and Lung Cancer Risk: A Case–Control Study in Never-Smokers
Conclusions: Never smoking SS homozygous individuals pose an increased risk of lung cancer. The risk is higher for individuals exposed to environmental tobacco smoke. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Targeted Therapy for Brain Metastases in EGFR-Mutated and ALK-Rearranged Non–Small-Cell Lung Cancer
Approximately half of all patients with non–small-cell lung cancer (NSCLC) develop brain metastases (BM) during the course of their disease, leading to significant challenges in treatment. Molecular targeted tyrosine kinase inhibitors have proven effective for patients with activating mutations in the epidermal growth factor receptor gene and chromosomal rearrangements involving the anaplastic lymphoma kinase gene. Despite their efficacy in systemic disease control, their effectiveness in patients with BM is not well established. In this article, we review recent data on the use of epidermal growth factor receptor and an...
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: State of the Art: Concise Review Source Type: research
Treatment of Peripheral Non–Small Cell Lung Carcinoma with Stereotactic Body Radiation Therapy
Stereotactic body radiation therapy (SBRT) is an effective and well-tolerated noninvasive treatment for medically inoperable patients with peripheral non–small cell lung carcinoma. The term “peripheral” refers to lesions that lie 2 cm or more from the mediastinum and proximal bronchial tree and was instituted based on results from a specific dose and fractionation schedule. Improvements in immobilization, respiratory motion management, and image guidance have allowed for SBRT’s highly conformal and accurate delivery of large radiation doses per fraction. Results from prospective and retrospective studies suggest ...
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: State of the Art: Concise Review Source Type: research
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification
The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart has just been published with numerous important changes from the 2004 WHO classification. The most significant changes in this edition involve (1) use of immunohistochemistry throughout the classification, (2) a new emphasis on genetic studies, in particular, integration of molecular testing to help personalize treatment strategies for advanced lung cancer patients, (3) a new classification for small biopsies and cytology similar to that proposed in the 2011 Association for the Study of Lung Cancer/American Thoracic Soci...
Source: Journal of Thoracic Oncology - August 21, 2015 Category: Cancer & Oncology Tags: State of the Art: Concise Review Source Type: research
