Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations
NUT midline carcinoma (NMC) is a poorly differentiated tumor typically driven by a t(15;19) rearrangement leading to a NUT fusion event. This rare and uniformly fatal tumor arises in multiple organ sites; however the clinical, radiographic, and pathologic characteristics of primary pulmonary NMC are poorly defined. We identified eight cases of primary pulmonary NMC in our consult practice over 4 years and, using a NUT immunohistochemistry screen, retrospectively identified one additional case from 166 (0.6%) consecutive in-house biopsies of lung carcinomas lacking glandular differentiation. Eight cases had available clinic...
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Is Radiotherapy Useful for Treating Pain in Mesothelioma?: A Phase II Trial
Conclusions: Radiotherapy for pain control in MPM is an effective treatment in a proportion of patients. Future studies examining differing radiotherapy regimens with a view to improving response rates are warranted. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Patients Selected for Definitive Concurrent Chemoradiation at High-volume Facilities Achieve Improved Survival in Stage III Non–Small-Cell Lung Cancer
Conclusions: Our findings suggest that treatment at HVF is associated with improved overall survival among stage III NSCLC patients receiving definitive CCRT, independent of academic affiliation. Further research is needed to determine whether or not efforts supporting centralization of radiotherapy at HVF will improve population-based survival, toxicities, and costs.
Copyright (C) 2015 by the International Association for the Study of Lung Cancer (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Mediastinal Nodal Involvement in Patients with Clinical Stage I Non–Small-Cell Lung Cancer: Possibility of Rational Lymph Node Dissection
Conclusions: It would be acceptable to perform selective LND in patients with c-stage I NSCLC with ground glass opacity- predominant tumor. Elevated serum carcinoembryonic antigen was associated with upper mediastinal lymph node involvement in lower-lobe primary lung adenocarcinoma with radiologically solid-predominant tumor. We should be careful when applying selective LND to patients with solid-predominant tumor, especially located in the lower lobe. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
The Role of Extended Pulmonary Metastasectomy
Conclusions: Extended resections performed during pulmonary metastasectomies are associated with low mortality and morbidity rates and an acceptable long-term survival when performed in selected patients susceptible to complete resection. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation
Conclusions: Our results imply that EGFR-TKIs could not only directly inhibit tumor cell viability but also indirectly enhance antitumor immunity through the downregulation of PD-L1. Anti-PD-1/PD-L1 antibodies could be an optional therapy for EGFR-TKI sensitive patients, especially for EGFR-TKIs resistant NSCLC patients with EGFR mutation. Combination of EGFR-TKIs and anti-PD-1/PD-L1 antibodies treatment in NSCLC is not supported by the current study but warrant more studies to move into clinical practice. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
The BIM Deletion Polymorphism and its Clinical Implication in Patients with EGFR-Mutant Non–Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors
Conclusions: It remains to be determined whether the BIM deletion polymorphism provides intrinsic resistance or decreased sensitivity to EGFR TKIs in EGFR-mutant NSCLC patients. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
FDG Uptake on Positron Emission Tomography Correlates with Survival and Time to Recurrence in Patients with Stage I Non–Small-Cell Lung Cancer
Conclusions: Preoperative FDG uptake in the primary tumor in patients with stage I disease is associated with OS and TTR. This may be useful in identifying early stage patients who may benefit from more aggressive therapy after surgical resection.
Copyright (C) 2015 by the International Association for the Study of Lung Cancer (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Randomized Study on Early Detection of Lung Cancer with MSCT in Germany: Results of the First 3 Years of Follow-up After Randomization
Conclusion: Our recent data may not only settle one concern regarding high recall rates in routine MSCT screening but also indicate that screening must be strictly organized to be effective. Performance indicators are similar to those in mammography screening. Nevertheless, possible consequences for the participants (diagnostic workup of suspicious findings, biopsies) are more invasive than in mammography screening. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Symptom and Quality of Life Improvement in LUX-Lung 6: An Open-Label Phase III Study of Afatinib Versus Cisplatin/Gemcitabine in Asian Patients With EGFR Mutation-Positive Advanced Non–small-cell Lung Cancer
Conclusion: Afatinib improved PFS and PROs versus chemotherapy in EGFR mutation-positive NSCLC patients. Progression was associated with statistically significant worsening in QoL measured before tumor assessment, underscoring the value of PFS as a clinically relevant end point. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Stereotactic Ablative Radiation Therapy for the Treatment of Early-stage Non–Small-Cell Lung Cancer: CEPO Review and Recommendations
The objective of this guideline is to review the efficacy and safety of SABR in these two clinical situations and to develop evidence-based recommendations.
Method: A review of the scientific literature published up to December 2013 was performed. A total of 44 publications were included.
Recommendations: Considering the evidence available to date, the Comité de l’évolution des pratiques en oncologie recommends the following: (1) for medically operable patients with stage T1-2N0M0 NSCLC, surgery remains the standard treatment because comparative data regarding the efficacy of SABR and surgery are currently insufficient...
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: State of the Art: Concise Review Source Type: research
Increasing Physical Activity and Exercise in Lung Cancer: Reviewing Safety, Benefits, and Application
Lung cancer continues to be a difficult disease frequently diagnosed in late stages with a high mortality and symptom burden. In part because of frequent lung comorbidity, even lung cancer survivors often remain symptomatic and functionally limited. Though targeted therapy continues to increase treatment options for advanced-stage disease, symptom burden remains high with few therapeutic options. In the last several decades, exercise and physical activity have arisen as therapeutic options for obstructive lung disease and lung cancer. To date, exercise has been shown to reduce symptoms, increase exercise tolerance, improve...
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: State of the Art: Concise Review Source Type: research
In This Issue/Research Watch/News in Brief/News From the Iaslc Tobacco Control Committee
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - May 23, 2015 Category: Cancer & Oncology Tags: In This Issue/Research Watch/News in Brief/News From the Iaslc Tobacco Control Committee Source Type: research
Reply to “Diminishing Role of Platinum-Sensitivity Status in Patients with Small Cell Lung Cancer”
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
Second-line Treatment of Small Cell Lung Cancer: Is Platinum Sensitivity a Relevant Prognostic Factor?
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
