Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas
Conclusion: The presence of STAS is a significant risk factor of recurrence in small lung adenocarcinomas treated with limited resection. These findings support our proposal that STAS should formally be recognized as a pattern of invasion in lung adenocarcinoma. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Heterogeneity of Anaplastic Lymphoma Kinase Gene Rearrangement in Non–Small-Cell Lung Carcinomas: A Comparative Study Between Small Biopsy and Excision Samples
Introduction: The standard diagnostic method for echinoderm microtubule-associated protein-like 4-anaplastic lymphoma receptor tyrosine kinase translocation is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has been reported as a potential method in screening for anaplastic lymphoma kinase (ALK)-positive non–small-cell lung carcinomas (NSCLC), whereas several authors have reported a discordance between FISH and IHC results. We investigated the heterogeneity of ALK gene rearrangement in excision specimens by FISH and also examined whether the FISH score of ALK gene rearrangement correspond...
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment Response in Advanced Lung Adenocarcinomas with G719X/L861Q/S768I Mutations
Conclusion: Gefitinib and erlotinib are active in patients with G719X/L861Q/S768I mutations; however, less effective than in those with common mutations. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Diagnostic Mutation Profiling and Validation of Non–Small-Cell Lung Cancer Small Biopsy Samples using a High Throughput Platform
Conclusions: The LungCarta panel is a sensitive method of screening for multiple alterations (214 mutations across 26 genes) and which optimizes the use of limited amounts of tumor DNA isolated from small specimens. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
High Discrepancy of Driver Mutations in Patients with NSCLC and Synchronous Multiple Lung Ground-Glass Nodules
Conclusions: We found a high discrepancy of driver mutations among NSCLC patients with GGNs and a favorable prognosis after multiple lesions resection, which support surgical resection in this situation as a reasonable approach. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience
Conclusion: Multi-institutional molecular analysis across multiple platforms, sample types, and institutions can yield consistent results and novel clinicopathological observations. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Lung Cancer Workshop XI: Tobacco-Induced Disease: Advances in Policy, Early Detection and Management
The Prevent Cancer Foundation Lung Cancer Workshop XI: Tobacco-Induced Disease: Advances in Policy, Early Detection and Management was held in New York, NY on May 16 and 17, 2014. The two goals of the Workshop were to define strategies to drive innovation in precompetitive quantitative research on the use of imaging to assess new therapies for management of early lung cancer and to discuss a process to implement a national program to provide high quality computed tomography imaging for lung cancer and other tobacco-induced disease. With the central importance of computed tomography imaging for both early detection and volu...
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Phenotypic Heterogeneity of Potentially Curable Non–Small-Cell Lung Cancer: Cohort Study with Cluster Analysis
Conclusion: Staging of patients with non–small-cell lung cancer for prognostic purposes may be improved by considering phenotypes that exhibit significant differences in clinical course and outcome. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Baseline Characteristics and Mortality Outcomes of Control Group Participants and Eligible Non-Responders in the NELSON Lung Cancer Screening Study
Conclusion: Modest differences in baseline characteristics between participants and eligible nonresponders, led to minor differences in mortality profiles. However, group sizes were large and therefore it seems unlikely that these small differences will influence the generalizability of the NELSON trial. Results of the NELSON trial can roughly be used to predict the effect of population-based lung cancer screening. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Distinct Epidemiology and Clinical Consequence of Classic Versus Rare EGFR Mutations in Lung Adenocarcinoma
Conclusions: The majority of rare EGFR mutations was associated with smoking, shorter overall survival, and decreased TKI response when compared with classic EGFR mutations. However, studies characterizing the TKI sensitizing effect of individual rare mutations are indispensable to prevent the exclusion of patients with sensitizing rare EGFR mutations who may benefit from anti-EGFR therapy. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
The Presence of Asbestos in the Natural Environment is Likely Related to Mesothelioma in Young Individuals and Women from Southern Nevada
Background: Inhalation of asbestos and other mineral fibers is known causes of malignant mesothelioma (MM) and lung cancers. In a setting of occupational exposure to asbestos, MM occurs four to eight times more frequently in men than in women, at the median age of 74 years, whereas an environmental exposure to asbestos causes the same number of MMs in men and women, at younger ages.
Methods: We studied the geology of Nevada to identify mineral fibers in the environment. We compared MM mortality in different Nevada counties, per sex and age group, for the 1999 to 2010 period.
Results: We identified the presence of carcinoge...
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
In Memoriam
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: In Memoriam Source Type: research
In This Issue/Research Watch/News in Brief/News From the Iaslc Tobacco Control Committee
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: In This Issue/Research Watch/News in Brief/News From the Iaslc Tobacco Control Committee Source Type: research
Adding Bevacizumab to Chemotherapy Effectively Control Radioresistant Brain Metastases in ALK-Positive Lung Adenocarcinoma
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research
Novel Association of Elastofibroma with Aortic Stenosis: Report of a Case Report Interfering with a Thoracotomy Procedure and a Reassessment of Typical Patient Demographics and Tumor Location
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Case Reports Source Type: research
