Erlotinib Efficacy in NSCLC Patients with High Polysomy of Chromosome 7 and EGFR/KRas Wild-Type Tumors
Conclusion: Among the EGFR wild-type population, when analyzed separately, high polysomy of chromosome 7 was the only molecular feature conferring clear signs of sensitivity to erlotinib. Therefore, the evaluation of high polysomy of chromosome 7 could become a helpful tool to predict for the benefit from epidermal growth factors tyrosine kinase inhibitors in selected cases. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - January 29, 2015 Category: Cancer & Oncology Tags: Brief Reports Source Type: research
SWOG S0722: Phase II Study of mTOR Inhibitor Everolimus (RAD001) in Advanced Malignant Pleural Mesothelioma (MPM)
Conclusion: Everolimus has limited clinical activity in advanced MPM patients. Additional studies of single-agent everolimus in advanced MPM are not warranted. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - January 29, 2015 Category: Cancer & Oncology Tags: Brief Reports Source Type: research
A Mass Spectrometry Assay to Simultaneously Analyze ROS1 and RET Fusion Gene Expression in Non–Small-Cell Lung Cancer
Conclusion: The novel multiplexed assay is robustly capable of detecting 15 different clinically relevant RET and ROS1 fusion variants. The benefits of this detection method include exceptionally low sample input, high cost efficiency, flexibility, and rapid turnover. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - January 29, 2015 Category: Cancer & Oncology Tags: Brief Reports Source Type: research
Massively Parallel Sequencing Identifies Recurrent Mutations in TP53 in Thymic Carcinoma Associated with Poor Prognosis
Conclusions: Next-generation sequencing of cancer genes in thymic epithelial tumors revealed a low frequency of mutation, with different patterns between TCA and B3 thymomas. TP53 and BCOR were the most frequently mutated genes in TCA and B3 thymomas, respectively. Alterations in p53 are associated with worse prognosis in TCA. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - January 29, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
The Impact of Thymoma Histotype on Prognosis in a Worldwide Database
Conclusion: New findings are (1) geographic differences such as a lower incidence of type A and B2 thymoma in Asia; and (2) impact of stage and histology, the latter partially limited to early stage disease, on recurrence. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - January 29, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
