Comparison of Methods in the Detection of ALK and ROS1 Rearrangements in Lung Cancer
Conclusion: Our findings show good correlation between FISH versus CISH in the detection of ALK and ROS1 rearrangements. FISH versus IHC showed good correlation in the detection of ALK rearrangements but showed weak correlation in the detection of ROS1 rearrangements. These results suggest CISH and IHC could be complimentary detection methods to FISH in the detection of ALK and ROS1 rearrangements. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Dynamic Plasma EGFR Mutation Status as a Predictor of EGFR-TKI Efficacy in Patients with EGFR-Mutant Lung Adenocarcinoma
Conclusion: Changes in plasma EGFR mutation status can be successfully assessed using the peptide nucleic acid–zip nucleic acid polymerase chain reaction clamp method and can serve as an independent outcome predictor. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
ALK Testing in Lung Adenocarcinoma: Technical Aspects to Improve FISH Evaluation in Daily Practice
Conclusions: Difficulties in ALK FISH signal interpretation might be bypassed using this detailed scoring system, which is highly reproducible, helps clarify borderline samples (according to split type), and provides experimental evidence that 15% is a reasonable cutoff to overcome the assay-dependent background noise. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Cost-Effectiveness of Multiplexed Predictive Biomarker Screening in Non-Small-Cell Lung Cancer
Conclusion: From a societal perspective, our cost-effectiveness results support the value of multiplexed genetic screening and molecularly guided therapy in metastatic NSCLC. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Stereotactic Ablative Radiotherapy for Centrally Located Early Stage Non–Small-Cell Lung Cancer: What We Have Learned
Image-guided stereotactic ablative radiotherapy (SABR; also called stereotactic body radiotherapy or radiosurgery) has become a standard treatment for medically inoperable peripherally located stage I non–small-cell lung cancer (NSCLC) and can achieve local control rates in excess of 90%. However, the role of SABR for centrally located lesions remains controversial because of concerns about the potential for severe toxic effects. When cutting-edge technologies and knowledge-based optimization of SABR planning that considers both target coverage and normal tissue sparing are used, some patients with central lesions can be...
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: State of the Art: Concise Review Source Type: research
High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma
Conclusions: Our findings conclusively establish BAP1 as the most commonly mutated gene in MM, regardless of ethnic background or other clinical characteristics. Our data point to IHC as the most accessible and reliable technique to detect BAP1 status in MM biopsies. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
The Comparative Pathology of Genetically Engineered Mouse Models for Neuroendocrine Carcinomas of the Lung
Conclusion: The five GEMM models studied are representative for the entire spectrum of human high-grade NE carcinomas and are also useful for the study of multistage pathogenesis and the metastatic properties of these tumors. They represent one of the most advanced forms of currently available GEMM models for the study of human cancer. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Comparisons between Mouse and Human Studies Will Help the Prevention, Diagnosis, and Treatment of the Deadliest Type of Lung Cancer
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Editorials Source Type: research
ALK FISH and IHC: You Cannot Have One without the Other
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Editorials Source Type: research
Plasma-Based Tumor Genetics for Monitoring Disease Progression: What Can We Learn from a Tube of Blood?
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Editorials Source Type: research
In This Issue/Research Watch/News in Brief/News from the IASLC Tobacco Control Committee
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: In This Issue/Research Watch/News in Brief/News from the IASLC Tobacco Control Committee Source Type: research
Acknowledgment of Reviewers
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - March 21, 2015 Category: Cancer & Oncology Tags: Acknowledgment of Reviewers Source Type: research
Reply to “Pulmonary Metastasectomy: Where is the Evidence?”: Absence of Evidence is not Evidence of Absence!
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research
Pulmonary Metastasectomy: Where is the Evidence?
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research
pN Categories Based on Metastatic Lymph Node Counts are Still the Cornerstone in Operable Esophageal Cancer
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - February 21, 2015 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research
