Relevance of Platinum Sensitivity in Patients with Relapsed or Refractory Small-Cell Lung Cancer
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
MET-Mutated NSCLC with Major Response to Crizotinib
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research
Reply to: “Lymph Node/Tumor SUVmax Ratio Can Predict Metastasis to Mediastinal Lymph Nodes in Lung Cancer Patients”
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
Lymph Node/Tumor SUVmax Ratio Can Predict Metastasis to Mediastinal Lymph Nodes in Lung Cancer Patients
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
MET Mutation Associated with Responsiveness to Crizotinib
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
CSF Concentration of Crizotinib in Two ALK-Positive Non–Small-Cell Lung Cancer Patients with CNS Metastases Deriving Clinical Benefit from Treatment
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Case Report Source Type: research
Response to Crizotinib/Erlotinib Combination in a Patient with a Primary EGFR-Mutant Adenocarcinoma and a Primary c-met–Amplified Adenocarcinoma of the Lung
Targeted therapy has become a valuable approach in adenocarcinoma of the lung. The number of actionable mutations has been continuously increasing with significant acceleration from discovery to clinical application. Herein, we present a case of innovative treatment using targeted therapy of a 75-year-old female with two primary adenocarcinomas of the lung. The first tumor was found to carry an activating mutation in the exon 19 of the epidermal growth factor receptor and responded favorably to treatment with erlotinib. The second primary tumor was found to carry an isolated amplification of the c-met gene but no epidermal...
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Case Report Source Type: research
Paraneoplastic Limbic Encephalitis and Small-Cell Lung Carcinoma
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Image of the Month Source Type: research
Hippo Pathway Gene Mutations in Malignant Mesothelioma: Revealed by RNA and Targeted Exon Sequencing
Conclusions: The frequent alterations of Hippo pathway molecules found in this study indicate the therapeutic feasibility of targeting this pathway in patients with MM. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Updated Frequency of EGFR and KRAS Mutations in NonSmall-Cell Lung Cancer in Latin America: The Latin-American Consortium for the Investigation of Lung Cancer (CLICaP)
Conclusion: Our findings support the genetic heterogeneity of NSCLC in Latin America, confirming that the frequency of EGFR mutations is intermediate between that observed in the Asian and Caucasian populations. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Central versus Peripheral Tumor Location: Influence on Survival, Local Control, and Toxicity Following Stereotactic Body Radiotherapy for Primary Non–Small-Cell Lung Cancer
Conclusions: Central tumor location did not predict for inferior OS, LC, or toxicity following SBRT when a lower mean BED was utilized. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Patterns of Recurrence and Survival after Surgery or Stereotactic Radiotherapy for Early Stage NSCLC
Conclusions: In patients with fluoro-deoxyglucose positron emission tomography/computed tomography-based stage I NSCLC, SABR confers worse locoregional tumor control because of more nodal failures compared with surgery, stressing the need to improve mediastinal and hilar staging. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy
The objectives of this study are to comprehensively evaluate the significance of CRM1 in lung cancer development and investigate the therapeutic potential of targeting CRM1 for lung cancer treatment using both in vitro and in vivo models. We showed that CRM1 was overexpressed not only in lung tumor tissues from both lung cancer patients and mice treated with NNK but also in NNK-transformed BEAS-2B human bronchial epithelial cells. Furthermore, stable overexpression of CRM1 in BEAS-2B cells by plasmid vector transfection led to malignant cellular transformation. Moreover, a decreased CRM1 expression level in A549 cells by s...
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Original Articles Source Type: research
9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk: Erratum
No abstract available (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 22, 2015 Category: Cancer & Oncology Tags: Erratum Source Type: research
