Aspirin use decreases the risk of prostate cancer recurrence after post-prostatectomy radiotherapy
Conclusion
In patients who received adjuvant and salvage radiation therapy after primary radical prostatectomy, aspirin use was associated with a decreased risk of biochemical failure. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 25, 2015 Category: Cancer & Oncology Source Type: research
A high lymph node ratio predicts loco-regional recurrence while microscopic N2 predicts survival after radiation therapy in pIIIA-N2 non-small cell lung cancer
Conclusion
Our study supports that LNR is likely related to OS and loco-regional recurrence. Furthermore, microscopic N2 seems to be associated with a better prognosis. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 23, 2015 Category: Cancer & Oncology Source Type: research
Liver dosimetric evaluation in biologically based stereotactic body radiotherapy for large inoperable hepatocellular carcinoma
Conclusions
MLD values derived for three-fraction and five-fraction SBRT by the NTCP method were consistent with established SBRT liver dose constraints. However, SBRT for large hepatocellular carcinomas may be limited by critical volume dose objectives. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 14, 2015 Category: Cancer & Oncology Source Type: research
Re-irradiation in lung cancer
This report examines data from the use of external beam radiation therapy, stereotactic body radiotherapy, and endobronchial brachytherapy for management of local-regional failure in lung cancer. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 2, 2015 Category: Cancer & Oncology Source Type: research
Systematic errors in lung stereotactic body radiation therapy (SBRT): a caution on mixing and matching target delineation methods and planning CTs
Conclusions
Depending on the reference images used, the COMs of the PTVFBCT, PTVBHCT, and PTV4D-CT are inconsistent, exhibiting significant shifts relative to each other. To avoid possible systematic localization errors, we recommend using 4D-CT/MIP for target delineation and AIP-CT for planning and alignment. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 2, 2015 Category: Cancer & Oncology Source Type: research
Reirradiation and stereotactic body radiotherapy for recurrent or second primary squamous cell carcinoma of the head and neck
Abstract
Recurrent or second primary squamous cell cancer of the head and neck in a previously irradiated field presents a therapeutic challenge in which outcomes are suboptimal and treatment is associated with significant risk of morbidity and mortality. Resection followed by risk-adapted adjuvant reirradiation, definitive reirradiation, and stereotactic body radiotherapy, all with the potential for concurrent systemic therapy, represent viable treatment strategies and can offer long-term disease control with acceptable quality of life for some of these patients. Careful patient selection based on patien...
Source: Journal of Radiation Oncology - March 29, 2015 Category: Cancer & Oncology Source Type: research
Re-irradiation of central nervous system tumors
This report reviews data for efficacy and safety of re-irradiation in managing recurrent or progressive CNS (brain and spine) tumors. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 17, 2015 Category: Cancer & Oncology Source Type: research
Change in radiotherapy treatment volumes with initial alkylating chemotherapy in anaplastic gliomas
Conclusion
Chemotherapy results in an initial volumetric response. However, RT volumes at salvage are not meaningfully different than baseline. Patients without response by 90 days are likely to require RT to significantly larger volumes at progression. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 13, 2015 Category: Cancer & Oncology Source Type: research
A systematic review on the role for reirradiation in locally recurrent rectal cancer
Conclusion
Reirradiation for locally recurrent rectal cancer provides an acceptable toxicity profile and results in encouraging local control and overall survival. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 13, 2015 Category: Cancer & Oncology Source Type: research
Metabolic response assessment with 18 F-FDG PET/CT: inter-method comparison and prognostic significance for patients with non-small cell lung cancer
Conclusions
There was a modest discrepancy in metabolic response rates between PM and UM criteria, though both could offer predictive classification for survival. The percentage decrease provides an ordinal value that correlates with prolonged survival, recommending 75 % as the optimal threshold at identifying better responders. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 12, 2015 Category: Cancer & Oncology Source Type: research
Outcomes after palliative re-irradiation of spinal metastases
Conclusion
Patients undergoing re-RT for spinal metastases have a poor prognosis. No RM was observed after re-RT largely respecting published low-risk criteria. Neurologic injury from progression was common. Further study of exceeding the low-risk criteria, particularly among poor prognosis patients, may be warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 10, 2015 Category: Cancer & Oncology Source Type: research
Adjuvant chemoradiation may improve survival over adjuvant chemotherapy in resected pancreatic cancer patients who are high risk for locoregional recurrence
Conclusion
Adjuvant chemoradiation significantly decreases LRR in resected pancreatic cancer patients compared to adjuvant chemotherapy. Significant predictors of survival on MVA were LRR and N-category. Additionally on subgroup analysis, chemoradiation improved survival over chemotherapy with a (1) positive surgical margin and/or (2) LNR ≤0.2 with ≥8 LNs dissected. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 1, 2015 Category: Cancer & Oncology Source Type: research
Comparison of Monte Carlo with pencil beam dosimetry for lung CyberKnife SBRT, correlation with local recurrence
Conclusions
Without the use of MC planning, target structures were substantially underdosed. Local failures were associated with PTVmicro undercoverage, which suggests delivering a therapeutic dose to this expanded microscopic disease target volume is beneficial. MC dosimetry is preferable for lung SBRT, while the PB algorithm was adequate for predicting pulmonary toxicity. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - February 19, 2015 Category: Cancer & Oncology Source Type: research
Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry
Conclusion
SBRT for T1–T2 NSCLC is feasible and effective in the community setting. OS was greater for patients with T1 lesions compared to T2 lesions. An improvement in LC was observed in patients with T2 lesions treated with BED10 > 105 Gy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 30, 2015 Category: Cancer & Oncology Source Type: research
Gastric cancer recurrence after resection and adjuvant chemoradiation
Conclusions
Isolated LRR in this study was uncommon. The predominant pattern was distant failure. This is in keeping with other studies that have observed lower rates of LRR with adjuvant chemoradiation after curative resection of gastric cancer. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 29, 2015 Category: Cancer & Oncology Source Type: research
