Radiation dose-fractionation effects in spinal cord: comparison of animal and human data
Conclusion
The study showed that all four groups had similar α/β ratios close to 3.9 Gy, suggesting that the spinal cord has a similar fractionation effect for different species, including human beings. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 14, 2015 Category: Cancer & Oncology Source Type: research
Outcome of Adult Brain Tumor Consortium (ABTC) prospective dose-finding trials of I-125 balloon brachytherapy in high-grade gliomas: challenges in clinical trial design and technology development when MRI treatment effect and recurrence appear similar
Conclusion
These trials failed to determine a maximum tolerated dose (MTD) for further testing as early imaging changes, presumed to be progression, were common and interfered with the assessment of treatment-related toxicity. The survival outcomes in these and other related studies, although based on small populations, suggest that GSBT may be worthy of further study using clinical and survival endpoints, rather than standard imaging results. The implications for local therapy development are discussed. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 5, 2015 Category: Cancer & Oncology Source Type: research
Outcomes of primary mucosal melanoma originated from sinonasal tract
Conclusion
SNMM is a devastating tumor, with high risk for local failure as well as distant metastases. The stage of the primary disease, i.e., the extent of tumor infiltration, is the predominant factor influencing the prognosis. OS and DFS after surgery followed by radiation therapy remain suboptimal. Further researches for novel treatment strategies such as targeted therapy are necessary to improve the outcomes. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 1, 2015 Category: Cancer & Oncology Source Type: research
Quality of life after intensity-modulated radiation therapy for anal cancer
Conclusion
Overall quality of life scores were acceptable, but sexual functioning scores were suboptimal after IMRT for anal cancer. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 26, 2015 Category: Cancer & Oncology Source Type: research
Interval to biochemical failure is prognostic for distant metastases after salvage radiation therapy for prostate cancer
Conclusions
Patients with IBF < 18 months are at significantly higher risk of DM and death from prostate cancer. The IBF may be used to guide patients and physicians considering the initiation of salvage ADT. Furthermore, an IBF < 18 months could be used to select “high-risk” patients for clinical trials investigating novel salvage systemic therapy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 26, 2015 Category: Cancer & Oncology Source Type: research
American College of Radiation Oncology (ACRO)
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 16, 2015 Category: Cancer & Oncology Source Type: research
Gold fiducial marker tracking to optimize radiotherapy for organ-preserving treatment of muscle-invasive bladder cancer
Conclusions
This is the first case series of intra-fraction GSM tracking for organ-preserving treatment of muscle-invasive bladder cancer. The data suggest that GSM tracking during radiotherapy for bladder cancer is feasible and associated with minimal intra- and inter-fraction displacement. With prospective investigation, this technique may be used to minimize target volumes and reduce radiation-associated toxicity. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 15, 2015 Category: Cancer & Oncology Source Type: research
The proceedings of acro 2015
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 9, 2015 Category: Cancer & Oncology Source Type: research
Dose-volume relationship of acute and late small bowel toxicity from radiation therapy for prostate cancer: a Veterans Affairs study
Conclusion
In this Veterans Affairs population of prostate cancer patients treated with radiation, V45 < 200 cc minimizes small bowel toxicity. However, we show this constraint can possibly be exceeded without significant short- and long-term complications. Further studies should explore maximum tolerated dose-volume relationship to maximize tumor control without increasing the small bowel toxicity profile. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 9, 2015 Category: Cancer & Oncology Source Type: research
The α / β ratio dose-range independent: application of the generalized linear-quadratic (gLQ) model
Conclusion
The gLQ model provides dose-rate independent α/β ratio, suggesting greater stability of model parameters and more consistent interpretation of cell irradiation data. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 4, 2015 Category: Cancer & Oncology Source Type: research
Role of thrombocytopenia in radiation-induced mortality and review of therapeutic approaches targeting platelet regeneration after radiation exposure
Conclusion
Because there is currently no approved treatment stockpiled for radiation-induced thrombocytopenia, second-generation TPO mimetics and other novel platelet-promoting agents should be developed for this indication. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 1, 2015 Category: Cancer & Oncology Source Type: research
Impact of dose on lung ventilation change calculated from 4D-CT using deformable image registration in lung cancer patients treated with SBRT
Conclusions
This suggests that 4D-CT-derived ventilation maps can be used in treatment planning to spare functional lung volumes. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 13, 2015 Category: Cancer & Oncology Source Type: research
High-grade prostate adenocarcinoma (Gleason Score ≥8): survival and disease control following radical prostatectomy versus radiotherapy plus long-course hormone therapy
Conclusion
RT + HT-based treatment of high-grade prostate cancers demonstrates superior disease control compared with RP, without impact on disease-specific survival at 5 years. Further investigation is warranted in order to identify subset patient populations who may experience differential benefit from each approach. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 24, 2015 Category: Cancer & Oncology Source Type: research
Re-implantation following suboptimal dosimetry in low-dose-rate prostate brachytherapy: technique for outpatient source insertion using local anesthesia
Conclusions
Re-implantation under local anesthesia for LDR prostate brachytherapy improves suboptimal dosimetry and avoids the risk and cost of OR/anesthesia time. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 11, 2015 Category: Cancer & Oncology Source Type: research
Reirradiation of locally recurrent prostate cancer after primary radiotherapy
Abstract
Biochemical recurrence can occur after definitive treatment with external beam radiation therapy (EBRT) or brachytherapy (BRT) for localized prostate cancer. Prior to considering reirradiation for recurrent prostate cancer, appropriate patient selection is important in ensuring that patients are at a high likelihood for a local only recurrence. For appropriately selected patients, careful reirradiation using mostly brachytherapy techniques can provide durable long-term control with acceptable morbidity. Most of the published experience with reirradiation has been using low-dose rate (LDR) BRT, bu...
Source: Journal of Radiation Oncology - April 30, 2015 Category: Cancer & Oncology Source Type: research
