Radical treatment of muscle-invasive bladder cancer —are options equal?
ConclusionsPatients with MIBC can potentially be treated with surgery, or with bladder preserving techniques —RT and CRT. No randomised evidence exists to directly compare radical options and a frequently used neoadjuvant chemotherapy regime also lacks randomised data. Patients responded well to and tolerated fractionated gemcitabine and cisplatin. This regime can be used in patients with an eGFR as low as 40 ml/min.Our results support the use of chemo-radiotherapy or surgery as radical treatments in suitable patients with MIBC. All patients should be considered for and be given the option of both cystectomy and chemo-r...
Source: Journal of Radiation Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research
Image-guided adaptive radiotherapy improves acute toxicity during intensity-modulated radiation therapy for head and neck cancer
ConclusionThe use of an image-guided adaptive radiotherapy strategy reduced the incidence of high-grade skin toxicity and oral mucositis in the acute setting. Further studies are needed to better define which subset of patients may benefit the most. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research
Intraoperative radiation therapy as part of planned monotherapy for early-stage breast cancer
ConclusionsThe results of our series suggest the feasibility of utilizing IORT in a community-based cancer center with a high degree of local control, and patient satisfaction with regard to cosmesis. While the results of this series suggest that IORT may be a promising modality, longer follow-up is warranted to better understand exactly which clinicopathological features can predict long-term locoregional disease control. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research
Musculoskeletal outcomes and the effect of radiation to the vertebral bodies on growth trajectories for long-term survivors of high-risk neuroblastoma
ConclusionsMusculoskeletal abnormalities, below average height, and stunted in-field vertebral body growth are routine in long-term survivors of high-risk neuroblastoma. Sparing vertebral bodies when feasible may lead to improvement in patient growth trajectories. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research
An economic analysis of Radiation Therapy Oncology Group 94-10: cost-efficacy of concurrent vs. sequential chemoradiotherapy
ConclusionsIn patients with Medicare insurance and with significant toxicity burden, RT on day 50 is the least expensive but also least effective treatment in this subset of patients treated on RTOG 94-10. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research
Re-irradiation in gynecological cancers, present experiences and future hopes
ConclusionThe results of salvage re irradiation are reasonable. More upcoming evidences and ongoing technological innovations will guide us in more effective retreatment and addition to life in this group of patients. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 19, 2018 Category: Cancer & Oncology Source Type: research
Stereotactic radiosurgery practice patterns for brain metastases in the United States: a national survey
ConclusionsThis is one of the first national surveys assessing the use of SRS for brain metastases in clinical practice. These data highlight some clinical considerations for physicians treating brain metastases with SRS. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 11, 2018 Category: Cancer & Oncology Source Type: research
A comprehensive analysis of clinical trials including both immunotherapy and radiation therapy
ConclusionThe number of new ITRT clinical trials is increasing rapidly. This increase in quantity may improve the clinical application of the immunomodulatory properties of RT. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 10, 2018 Category: Cancer & Oncology Source Type: research
The albumin-bilirubin (ALBI) model in hepatocellular carcinoma (HCC) may better predict hepatic failure in patients with traditionally low-risk cirrhosis following definitive stereotactic body radiotherapy (SBRT)
ConclusionOur study indicates that the ALBI index more precisely predicted liver failure and survival in HCC following SBRT compared to CP scoring. Its application may help select the most ideal candidates for SBRT among the often heterogeneous CP-A population. Further study regarding precautionary measures such as functional treatment planning for ALBI-2 patients treated with liver SBRT may be warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 8, 2018 Category: Cancer & Oncology Source Type: research
Tolerability of sequential immune therapy and palliative radiotherapy to the cervical and thoracic spine
ConclusionsCombined immune therapy and radiotherapy for palliation of spine metastases suggests increased toxicity when a greater number of vertebral bodies are irradiated, or when combined immune therapy agents are utilized. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 3, 2018 Category: Cancer & Oncology Source Type: research
The proceedings of the radiation oncology summit: acro 2018
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 2, 2018 Category: Cancer & Oncology Source Type: research
Factors predictive of neoadjuvant versus adjuvant chemoradiotherapy in locally advanced rectal cancer and the impact on overall survival
ConclusionsThe use of neoadjuvant chemoradiotherapy for locally advanced rectal cancer is possibly associated with an overall survival benefit compared to ACRT subject to the limitations of this analysis. Margin status affects survival greatly. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 11, 2018 Category: Cancer & Oncology Source Type: research
Radical treatment of muscle-invasive bladder cancer —are options equal?
ConclusionsPatients with MIBC can potentially be treated with surgery, or with bladder preserving techniques —RT and CRT. No randomised evidence exists to directly compare radical options and a frequently used neoadjuvant chemotherapy regime also lacks randomised data. Patients responded well to and tolerated fractionated gemcitabine and cisplatin. This regime can be used in patients with an eGFR as low as 40 ml/min.Our results support the use of chemo-radiotherapy or surgery as radical treatments in suitable patients with MIBC. All patients should be considered for and be given the option of both cystectomy and chemo-r...
Source: Journal of Radiation Oncology - March 29, 2018 Category: Cancer & Oncology Source Type: research
Musculoskeletal outcomes and the effect of radiation to the vertebral bodies on growth trajectories for long-term survivors of high-risk neuroblastoma
ConclusionsMusculoskeletal abnormalities, below average height, and stunted in-field vertebral body growth are routine in long-term survivors of high-risk neuroblastoma. Sparing vertebral bodies when feasible may lead to improvement in patient growth trajectories. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 29, 2018 Category: Cancer & Oncology Source Type: research
An economic analysis of Radiation Therapy Oncology Group 94-10: cost-efficacy of concurrent vs. sequential chemoradiotherapy
ConclusionsIn patients with Medicare insurance and with significant toxicity burden, RT on day 50 is the least expensive but also least effective treatment in this subset of patients treated on RTOG 94-10. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 10, 2018 Category: Cancer & Oncology Source Type: research
