Correlates and trends of IMRT use in locally advanced rectal cancer
ConclusionsThe use of IMRT for locally advanced rectal cancer is increasing and surpassed 3DCRT as the most common radiation modality at the beginning of 2010. Intensity-modulated radiotherapy was given more commonly for adjuvant treatment than for neoadjuvant treatment and was associated with higher RT doses and treatment at an academic institution in the neoadjuvant setting. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 13, 2016 Category: Cancer & Oncology Source Type: research
Hypofractionated whole breast irradiation for early stage breast cancer in a large community-based physician practice
ConclusionThe use of hypofractionated whole breast irradiation has been found to be slowly increasing in the USA; however, it remains low. Additional studies are needed to evaluate the use of incentives with which to encourage the use of this cost-effective and efficacious treatment in the USA. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 6, 2016 Category: Cancer & Oncology Source Type: research
An overview of disparities research in access to radiation oncology care
ConclusionsDisparities in radiotherapy access remain pervasive throughout radiation oncology regardless of the organ system treated and are usually related to patient race and/or insurance status. Health disparities research in radiation oncology is relatively new; more than 70 % of studies have been published since the beginning of 2014. Vigilance remains required in combating this issue, as is further research into relatively unexplored organ systems to optimally assess the degree of health disparities in radiation oncology. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 6, 2016 Category: Cancer & Oncology Source Type: research
Nonoperative management of acoustic neuroma in geriatric patients: a National Cancer Database analysis
ConclusionsFifteen percent of the AN population is ≥ age 65, with surgery the most commonly used treatment modality. Male gender and CCC treatment independently predict receipt of radiation, while African-American race independently predicts receipt of observation. Given the proven impact of radiation on local control in AN, there is fertile groun d for dissemination of radiation treatment for geriatric AN patients. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 6, 2016 Category: Cancer & Oncology Source Type: research
Comparison of Yttrium-90 therapy for unresectable liver metastasis: glass versus biocompatible resin microspheres
ConclusionsTheraSphere microsphere appears superior to SIR-Spheres in treating non-HCC intrahepatic malignancy. However, patient selection and better multi-disciplinary care may play a role in these differences. Continued studies in combination therapies for all hepatic malignancies is critical to the long-term success and sustainability of Y-90 therapy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 1, 2016 Category: Cancer & Oncology Source Type: research
Radiosurgery for brainstem metastases with and without whole brain radiotherapy: clinical series and literature review
ConclusionThis retrospective series of patients treated with SRS for brainstem metastases, largely in combination with at least one course of WBRT, demonstrates that this approach is safe and results in good local control. In this cohort, no variables significantly impacted OS, including intracranial control. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 26, 2016 Category: Cancer & Oncology Source Type: research
The impact of 3D conformal radiotherapy versus intensity-modulated radiotherapy on post-operative wound complications in soft tissue sarcomas of the extremity and chest-wall
ConclusionsIMRT was associated with a significantly decreased risk of post-operative WCs compared to patients who received 3D CRT for their STS. Further studies and a larger sample size are needed to corroborate these findings. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 16, 2016 Category: Cancer & Oncology Source Type: research
Erratum to: A study of the factors affecting radiation-induced temporomandibular joint changes in post-radiotherapy nasopharyngeal carcinoma patients
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 16, 2016 Category: Cancer & Oncology Source Type: research
Long-term results of a phase I/II trial of the addition of celecoxib to chemoradiotherapy for locally advanced or recurrent squamous cell carcinoma of the head-and-neck
ConclusionCelecoxib appears to be a safe addition to cisplatin-based chemoradiotherapy for the primary treatment of locoregionally advanced SCCHN. Initial response rates were encouraging, and survival compared favorably with contemporary trials. Unfortunately, concern for cardiac toxicity of the drug led to early closure and limited statistical significance. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 12, 2016 Category: Cancer & Oncology Source Type: research
Erratum to: A phase II experience evaluating quality of life and survival in linac-based SBRT for prostate cancer
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 26, 2016 Category: Cancer & Oncology Source Type: research
Radiotherapy-related outcomes in pediatric patients with atypical teratoid thabdoid tumor of the central nervous system
ConclusionModern treatment for ATRT with intensive multimodality therapy including radiotherapy results in a significant portion of subjects with long-term disease control. Initial evidence demonstrates that focal proton therapy in very young subjects is feasible with limited toxicities. Prognosis appears to be improved in localized, completely resected disease. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 18, 2016 Category: Cancer & Oncology Source Type: research
Considerations in radiation therapy for pregnant women with malignancy
AbstractTreatment of pregnant women with cancer with radiation presents medical, technical, and ethical challenges. Cancer during pregnancy occurs in 1 out of 1000 cases. The most common cancers are those that are common in females of childbearing age, including breast cancer, cervical cancer, melanoma, Hodgkin lymphoma, and leukemia. The in utero radiation exposure of a developing fetus through diagnostic radiology/nuclear medicine and radiation therapy is always a concern for healthcare providers and parents. Radiation exposure to the fetus seems to be associated with increased incidences of childhood cancer at any fetal...
Source: Journal of Radiation Oncology - September 18, 2016 Category: Cancer & Oncology Source Type: research
Radiation therapy in the management of breast cancer brain metastases: the impact of receptor status on treatment response, intracranial recurrence, and survival
ConclusionReceptor subtypes that demonstrated poorer OS tended to demonstrate higher intracranial recurrence. A positive response to radiation was not associated with better OS or lower ICR. Identifying patterns based on receptor subtype may guide clinicians in management and surveillance for BCBM. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 30, 2016 Category: Cancer & Oncology Source Type: research
Comparison of treatment modalities for breast cancer arising in Hodgkin ’s lymphoma survivors
ConclusionBCT did not have an inferior CSS or OS compared to other treatment modalities for female HL survivors. BCT is an acceptable treatment option for a select group of female HL survivors who develop BC. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 30, 2016 Category: Cancer & Oncology Source Type: research
Stereotactic body radiation for pancreatic cancer: results of an international survey of practice patterns
ConclusionsSBRT is increasingly used for PCA. The data presented here indicate that the majority of radiation oncologists treat with 6 –8 Gy ×5 fractions and use fiducials with 4D-CT simulation for localization and planning. Although the majority of the surveyed physicians prefer SBRT to standard radiation, it may be underutilized due to the difficulty of obtaining insurance approval outside of a clinical trial. Our investigati on documents current pancreas SBRT practice patterns and highlights the need for prospective clinical trials as a means to develop consensus guidelines for this emerging treatment. (Source: Jour...
Source: Journal of Radiation Oncology - August 30, 2016 Category: Cancer & Oncology Source Type: research
