A phase II experience evaluating quality of life and survival in linac-based SBRT for prostate cancer
Conclusion
SBRT with VMAT for low-intermediate risk prostate cancer is well tolerated. Acute toxicities showed no apparent impact on patient general sense of well-being. No adverse effects were observed over the 36 month period. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 13, 2016 Category: Cancer & Oncology Source Type: research
The integration of radiation therapy and immunotherapy in melanoma management
Abstract
Melanoma has long been considered an “immunologic” malignancy because of numerous reports of spontaneous regression as well as abscopal phenomena along with its relative responsiveness to cancer immunotherapy. Over the past few years, there has been a resurgence of interest in cancer immunotherapy with particular focus on melanoma. Many new immunotherapeutic interventions have arisen, some with notable clinical efficacy. One such example is the current generation of checkpoint inhibitors. In this article, we shall review the recent data on checkpoint inhibition in melanoma along with a brief ...
Source: Journal of Radiation Oncology - May 5, 2016 Category: Cancer & Oncology Source Type: research
Transcatheter aortic valve replacement in patients with prior chest irradiation and severe aortic stenosis
Conclusions
TAVR is a safe and effective alternative treatment in aortic stenosis patients with prior chest irradiation and porcelain aorta and may very well become the preferred approach. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 4, 2016 Category: Cancer & Oncology Source Type: research
Comorbidity and androgen deprivation therapy use in men undergoing high-dose radiation for unfavorable-risk prostate cancer
Conclusion
While neoadjuvant ADT use decreased over the study period in men with unfavorable-risk PC undergoing brachytherapy, ADT use was not less likely in those with a history of CHF/MI. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 29, 2016 Category: Cancer & Oncology Source Type: research
Radiation therapy for the management of penile cancer
Conclusion
Penile cancer is an uncommon cancer that has historically been treated with penectomy. Although penectomy provides a high local control rate, it is associated with significant psychosocial side effects. Radiation therapy in the form of brachytherapy or external beam therapy offers an organ-preserving treatment option with high rates of local control and penile preservation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 28, 2016 Category: Cancer & Oncology Source Type: research
Outcomes after adjuvant radiation therapy for prostate cancer at a comprehensive cancer center
Conclusions
At MDACC, men referred for adjuvant radiation often have margin involvement and/or extraprostatic extension. Patients did well overall, with high 5- and 10-year freedom from failure. Gleason 8–9 disease was associated with increased failure after adjuvant radiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 25, 2016 Category: Cancer & Oncology Source Type: research
Merkel cell carcinoma: demographic, clinical, and treatment parameters of prognostic significance
Conclusions
Our study supports the efficacy of RT in improving LR control in MCC compared to excision alone and emphasizes the importance of surgical nodal evaluation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 17, 2016 Category: Cancer & Oncology Source Type: research
Best practices for safety improvement through high-volume institutional incident learning: lessons learned from 2 years
Conclusions
A unique high reporting volume institutional ILS has successfully resulted in numerous improvements in process, safety, and quality. Details for implementation and best practices for incident learning have been presented to allow adaptation in other practices. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 15, 2016 Category: Cancer & Oncology Source Type: research
A new imaging/therapy platform by using external radionuclide ( 192 Ir)
Conclusion
The 192Ir radionuclide can be used as a possible external radiation source for breast imaging. Considering 192Ir’s therapeutic application and outcomes from its imaging simulation by this study, a new imaging/therapy platform can be potentially created. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 15, 2016 Category: Cancer & Oncology Source Type: research
Radiographic changes in lung of patients treated with stereotactic ablative body radiation therapy: low-dose volumes as the driving force for radiographic change
Conclusion
The development of rRP and the fibrotic volume after SABR was correlated with the volume of lung that received lower doses of radiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - April 15, 2016 Category: Cancer & Oncology Source Type: research
Radiobiologically based analysis of the influence of breathing motion and DIR method on lung treatment plans
Conclusion
The radiobiological and dosimetric analyses showed the importance of taking into account the breathing motion during treatment planning. That was especially evident for smaller tumors and tumors with large motion extent. Also, the importance of choosing the proper DIR method was found to be great since it may lead to large differences in the accumulated 4D dose distribution. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - February 11, 2016 Category: Cancer & Oncology Source Type: research
Differential effects of patient-related factors on the outcome of radiation therapy for rectal cancer
Conclusion
Further research is warranted to confirm these results in order to develop new interventions to improve outcome from radiation treatment. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 27, 2016 Category: Cancer & Oncology Source Type: research
Impact of obesity on treatment-related adverse events, disease recurrence, and survival in women with cervical carcinoma
Conclusions
Treatment-related outcomes differed based on patient BMI. Future prospective studies are justified to identify whether interventions such as image-guided and adaptive treatment planning and intensity-modulated radiation therapy (IMRT) are effective in reducing treatment-related AEs for obese and underweight patients. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 25, 2016 Category: Cancer & Oncology Source Type: research
Low-dose aspirin mitigates acute radiation-induced genitourinary toxicity in patients with prostate adenocarcinoma
Conclusion
Aspirin use was associated with reduced acute GU toxicity in patients undergoing radiotherapy for PCA. While these results require prospective validation, aspirin use during radiotherapy for PCA should be considered, as low-dose aspirin is a safe, inexpensive medication separately indicated for many patients. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 25, 2016 Category: Cancer & Oncology Source Type: research
Propensity score matched comparison of SBRT versus IMRT for the treatment of localized prostate cancer
Conclusion
Our data support the hypothesis that SBRT has non-inferior efficacy and toxicity rates as IMRT. Given the lower cost and convenience for patients, SBRT may be considered as an alternative treatment for localized prostate cancer. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 23, 2016 Category: Cancer & Oncology Source Type: research
