Absolute volume of active bone marrow and total bone marrow spared in anal cancer patients using intensity modulated proton versus volumetric arc therapy
ConclusionThe volume of PBM and APBM spared has been shown to be strong predictors of acute hematologic toxicity. IMPT planning results in significantly greater PBM and APBM sparing compared to VMAT. The use of IMPT for anal cancer may result in lower HT rates in patients undergoing definitive chemoradiation through improved bone marrow sparing. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 10, 2017 Category: Cancer & Oncology Source Type: research
Stereotactic body radiation therapy for non-small cell lung cancer patients with prior history of thoracic surgery and/or radiation therapy: the influence of smoking, size, and central location on risk of complications
ConclusionsAfter prior thoracic surgery and/or radiation, SBRT retreatment for NSCLC provided durable local control and was well tolerated in most patients. Patients with a history of previously operated and/or radiated lung cancer with new central tumors, PTV volume> 30 mL, or smoking history ≥ 50 pack-years were at higher risk of complications from SBRT. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 10, 2017 Category: Cancer & Oncology Source Type: research
Effectiveness and toxicity of conventional radiotherapy treatment for painful spinal metastases: a detailed course of side effects after opposing fields versus a single posterior field technique
ConclusionConventional radiotherapy of painful spinal metastases provides limited toxicity. Radiotherapy technique is not an independent predictor of abdominal and skin toxicity of irradiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 19, 2017 Category: Cancer & Oncology Source Type: research
The dosimetric effects of limited elective nodal irradiation in volumetric modulated arc therapy treatment planning for locally advanced non-small cell lung cancer
ConclusionThe addition of LENI to VMAT plans for LA-NSCLC is feasible, with only modestly increased doses to OARs and marginal expected increase in associated toxicity. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 6, 2017 Category: Cancer & Oncology Source Type: research
Liver stereotactic radiotherapy (SRT) with functional treatment planning for patients with intermediate stage hepatocellular carcinoma (HCC)
ConclusionsLiver SRT with functional treatment planning is safe in intermediate hepatocellular carcinoma. Liver failure is not hastened despite the inclusion of 36% Child-Pugh B patients. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 5, 2017 Category: Cancer & Oncology Source Type: research
Influence of radiation treatment technique on outcome and toxicity in anal cancer
ConclusionThis report represents the largest series directly comparing concurrent chemotherapy with IMRT vs 3D-CRT for definitive treatment of anal cancer. IMRT significantly reduced acute and post-treatment toxicities and allowed for safe and effective pelvic dose escalation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 22, 2017 Category: Cancer & Oncology Source Type: research
The effect of resveratrol administration in irradiated mice on the induction of micronuclei in bone marrow
ConclusionsThese results propose that RSV protects X-radiation-induced DNA damage in mice bone marrow cells, which may be related to its antioxidant activity. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 17, 2017 Category: Cancer & Oncology Source Type: research
Active monitoring in non-invasive breast cancer: insight gained from a large national database
ConclusionsSeveral presurgical findings can predict for occult-invasive breast cancer including time from diagnosis to definitive surgery. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 27, 2017 Category: Cancer & Oncology Source Type: research
Defining an “ideal” continuous dose-volume constraint curve using literature recommended individual dose-volume thresholds for reducing rectal toxicity from external beam prostate radiation therapy
ConclusionOur “ideal” rectal dose-volume curve generated from literature dose-volume thresholds in the most stringent manner is realistic and achievable at high doses (≥60 Gy) and not realistic at intermediate and low doses (≤50 Gy). Standardizing rectal definition and dose-volume metrics will make publ ished analyses and dose-volume constraint recommendations easier to follow. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 20, 2017 Category: Cancer & Oncology Source Type: research
Stereotactic ablative radiotherapy with targeted MRI-defined gross tumor dose escalation for prostate cancer: dosimetric feasibility and interfraction robustness
ConclusionSelective high-precision (i.e., mpMRI-defined targets, daily volumetric image guidance, intraprostatic fiducials) SBRT with GTV dose escalation seems feasible, without incremental dose to OAR. Prospective studies to determine its clinical benefit are warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 11, 2017 Category: Cancer & Oncology Source Type: research
Maximizing survival in patients with muscle-invasive bladder cancer undergoing curative bladder-preserving radiotherapy: the impact of radiotherapy dose escalation
ConclusionsWhen treating patients with MIBC with curative bladder-preserving radiotherapy, RT doses of 62 –66 Gy have improved OS compared to lower doses, while dose escalation to 67–70 Gy does not improve survival. Our study does not support deviating from the standard of 64–66 Gy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 10, 2017 Category: Cancer & Oncology Source Type: research
Analysis of treatment effectiveness and complications associated with MammoSite ™ breast brachytherapy in patients treated at a single institution
ConclusionsThis case series of 78 patients having greater than 24 months of follow-up from a single institution provides important data regarding failure analysis with MammoSite™ accelerated partial breast irradiation. Our results show a higher rate of metastatic recurrence in the group of patients with positive nodal disease. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 3, 2017 Category: Cancer & Oncology Source Type: research
Intratumoral treatment with radioactive beta-emitting microparticles: a systematic review
ConclusionThe large variety of particles, techniques, and treated tumors in the studies provided an important insight into issues concerning efficacy, safety, particle and isotope choice, and other concepts for future research. Animal studies showed efficacy and a dose response. Most studies in humans concluded that intratumoral treatment with radioactive beta-emitting microparticles is relatively safe and effective. Conflicting evidence about safety and efficacy might be explained by the considerable variation in the treatment characteristics. Larger particles had a better retention which resulted in higher anti-tumor eff...
Source: Journal of Radiation Oncology - June 24, 2017 Category: Cancer & Oncology Source Type: research
The proceedings of acro 2017
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 2, 2017 Category: Cancer & Oncology Source Type: research
Hemostatic radiotherapy in advanced bladder cancer: a single-institution experience
ConclusionPalliative bladder RT conferred an initial complete hemostatic response in a majority of patients. While in absolute terms the duration of hemostasis was relatively modest, on average bleeding was controlled following RT for the majority of the remaining life expectancy in this population with advanced bladder malignancy and a poor prognosis. Prospective trials assessing the value of hemostatic RT are encouraged. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 2, 2017 Category: Cancer & Oncology Source Type: research
