Journal of Diabetes and Its Complications This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Age, age at diagnosis and diabetes duration are all associated with vascular complications in type 2 diabetes
Type 2 diabetes (T2DM) is increasingly diagnosed in younger patients. The trajectory of complications in patients diagnosed at a younger or older age is not well understood. Here we examine the associations between age, age at diagnosis and diabetes duration and vascular complications in patients with T2DM. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - December 6, 2017 Category: Endocrinology Authors: Natalie Nanayakkara, Sanjeeva Ranasinha, Adelle Gadowski, Stephane Heritier, Jeff R. Flack, Natalie Wischer, Jencia Wong, Sophia Zoungas Source Type: research

The Role of lnc-DC long non-coding RNA and SOCS1 in the Regulation of STAT3 in Coronary Artery Disease and Type 2 Diabetes Mellitus
Coronary artery disease (CAD) can be classified as an inflammatory disease, which affected by type 2 diabetes mellitus (T2DM). Elevated levels of many inflammatory molecules were found in the serum of patients with CAD. STAT3 molecule as a transcription factor plays an important role in the cytokines expression. Here, we examined the expression levels of STAT3 and its important regulatory genes lnc-DC and SOCS1, in patients with CAD and T2DM. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - December 6, 2017 Category: Endocrinology Authors: Asieh Alikhah, Majid Pahlevan Kakhki, Amirhossain Ahmadi, Reyhaneh Dehghanzad, Mohammad Ali Boroumand, Mehrdad Behmanesh Source Type: research

Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity
In this study, we reassessed the role of ROS in glucose-induced sensory axon degeneration and analyzed candidate downstream targets, which could represent druggable targets. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - December 6, 2017 Category: Endocrinology Authors: Ashley L. Waldron, Patricia A. Schroder, Kelly L. Bourgon, Jessie K. Bolduc, James L. Miller, Adriana D. Pellegrini, Amanda L. Dubois, Magdalena Blaszkiewicz, Kristy L. Townsend, Sandra Rieger Source Type: research

Stress hyperglycemia in general surgery: Why should we care?
To determine the frequency of increasing levels of stress hyperglycemia and its associated complications in surgery patients without a history of diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 29, 2017 Category: Endocrinology Authors: Georgia Davis, Maya Fayfman, David Reyes-Umpierrez, Shahzeena Hafeez, Francisco J. Pasquel, Priyathama Vellanki, J. Sonya Haw, Limin Peng, Sol Jacobs, Guillermo E. Umpierrez Source Type: research

Deintensification of hypoglycaemic medications-use of a systematic review approach to highlight safety concerns in older people with type 2 diabetes
Intensive treatment of older people with diabetes is common placing them at increased risk of adverse events such as hypoglycaemia and hospitalisation for drug errors. Little is known about when, how or for whom to deintensify hypoglycaemic medications. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 29, 2017 Category: Endocrinology Authors: A.H. Abdelhafiz, A.J. Sinclair Tags: Review article Source Type: research

Coronary artery calcifications and diastolic dysfunction versus visceral fat area in type 1 diabetes: VISCERA study
Type 1 diabetic patients (T1DM) experience a higher cardiovascular disease and mortality risk than controls. We investigated whether visceral adipose tissue (VAT) contributes to coronary artery calcifications (CAC) and cardiac dysfunction in T1DM. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 28, 2017 Category: Endocrinology Authors: Christophe E.M. De Block, Bharati Shivalkar, Wouter Goovaerts, Tim Brits, Ken Carpentier, An Verrijken, Viviane Van Hoof, Paul M. Parizel, Chris Vrints, Luc F. Van Gaal Source Type: research

Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice
Low levels of reactive oxygen species and resulting oxidative protein modifications may play a beneficial role in cellular function under stress conditions. Here we studied the influence of age-dependent protein carbonylation on expression and activity of the anti-oxidative selenoenzyme glutathione peroxidase (GPx) in insulin-deficient Ins2Akita mice and type 2 diabetic obese db/db mice in context of diabetic nephropathy. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 21, 2017 Category: Endocrinology Authors: Tanja Wiedenmann, Nadine Dietrich, Thomas Fleming, Sandro Altamura, Leo E. Deelman, Rob H. Henning, Martina U. Muckenthaler, Peter P. Nawroth, Hans-Peter Hammes, Andreas H. Wagner, Markus Hecker Source Type: research

Challenges in defining, diagnosing, and treating diabetic gastroparesis
Gastroparesis is a highly symptomatic, multi-factorial disorder characterized by nausea, vomiting, early satiety, abdominal pain, and bloating, in combination with delayed gastric emptying without obstruction.1 Although the incidence is relatively low in the general population, individuals with diabetes have a substantially increased risk of developing gastroparesis, reported as being over 7-times higher risk for type 2 diabetes, and 30-times higher risk for type 1 diabetes.2 These associations are explained by several factors, including oxidative stress on the interstitial cells of Cajal (ICC), autonomic neuropathy and im...
Source: Journal of Diabetes and Its Complications - November 20, 2017 Category: Endocrinology Authors: Timothy R. Angeli, Gregory O ’Grady Source Type: research

Metformin and vitamin B12 —What's missing from this picture?
Over the past several years, increasing attention has been paid to the association of chronic metformin treatment with low levels of vitamin B12. Anecdotal reports of the association, thought to be due to impaired B12 absorption from the gastrointestinal track, have been available for decades. More recently, some well-designed studies, including two randomized clinical trials, have more clearly documented the magnitude and time frame of the risk.1 –3 As a result, periodic measurement of B12 levels in metformin treated patients is now recommended. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 15, 2017 Category: Endocrinology Authors: Jill P. Crandall Source Type: research

Metformin and Vitamin B12- what ’s missing from this picture?
Over the past several years, increasing attention has been paid to the association of chronic metformin treatment with low levels of vitamin B12. Anecdotal reports of the association, thought to be due to impaired B12 absorption from the gastrointestinal track, have been available for decades. More recently, some well-designed studies, including two randomized clinical trials, have more clearly documented the magnitude and time frame of the risk12.3 As a result, periodic measurement of B12 levels in metformin treated patients is now recommended. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 15, 2017 Category: Endocrinology Authors: Jill P. Crandall Source Type: research

Bone mineral density and markers of bone turnover and inflammation in diabetes patients with or without a Charcot foot: An 8.5-year prospective case-control study
Charcot osteoarthropathy (Charcot foot, CF) is a rare but severe complication to diabetes mellitus and peripheral neuropathy, and is associated with increased morbidity and mortality.1 It manifests as an aseptic inflammation of bones and joints in the feet leading to progressive degeneration of the bone structures, which can cause deformity and ulceration.2 –5 The treatment consists of long-term off-loading, often accompanied by assisted wound healing and surgery.6,7 (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 10, 2017 Category: Endocrinology Authors: Rasmus Bo Jansen, Tomas M øller Christensen, Jens Bülow, Lene Rørdam, Per E. Holstein, Niklas Rye Jørgensen, Ole Lander Svendsen Source Type: research

Relationship Between Individual Categories of Adverse Childhood Experience and Diabetes in Adulthood in a Sample of US Adults: Does it Differ by Gender?
Adverse Childhood Experiences (ACEs) are known to increase risk for poor health outcomes in adulthood and impact the development of chronic illness, specifically diabetes. However, little is known about the differential impact of individual ACE categories on diabetes risk, and whether this relationship is gender specific. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 10, 2017 Category: Endocrinology Authors: Jennifer A. Campbell, Gail C. Farmer, Selena Nguyen-Rodriguez, Rebekah Walker, Leonard Egede Source Type: research

Cereal Fiber, Fruit Fiber, and Type 2 Diabetes: Explaining the Paradox
While the relationship between dietary fiber and type 2 diabetes mellitus (T2DM) has been much studied, the evidence about its role in the prevention and control of this condition has been conflicting. We critically evaluate prospective cohort studies and randomized controlled trials (RCTs) that examined insoluble/nonviscous/cereal fiber and soluble/viscous/fruit fiber in relation to risk of T2DM. Taken as a whole this evidence indicates that, in the quantities typically eaten, cereal fiber is protective against T2DM while fruit fiber gives little protection. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 9, 2017 Category: Endocrinology Authors: Karen M. Davison, Norman J. Temple Tags: Review article Source Type: research

Urinary miRNA-377 and miRNA-216a as biomarkers of nephropathy and subclinical atherosclerotic risk in pediatric patients with type 1 diabetes
Urinary microRNAs (miRNAs) play a role in the pathogenesis of chronic kidney disease (CKD). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 7, 2017 Category: Endocrinology Authors: Mona Hussein El-Samahy, Amira Abdel Moneam Adly, Yasmine Ibrahim Elhenawy, Eman Abdel Rahman Ismail, Shaimaa Abdelmalik Pessar, Mohamed El-Sayed Mowafy, Mohammed Salah Saad, Hossam Hassan Mohammed Source Type: research

Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post Hoc Analysis of a randomized controlled 4.3 year trial
Metformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial. We studied the effects of metformin on serum levels of methylmalonic acid (MMA), a biomarker for tissue B12 deficiency, and on onset or progression of neuropathy. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 7, 2017 Category: Endocrinology Authors: Mattijs Out, Adriaan Kooy, Philippe Lehert, Casper A. Schalkwijk, Coen D.A. Stehouwer Source Type: research