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Effects of glycemic variability and hyperglycemia in acute ischemic stroke on post-stroke cognitive impairments
We aimed to investigate the effect of glycemic variability in the acute stage of stroke on the development of post-stroke cognitive impairment (PSCI). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 28, 2018 Category: Endocrinology Authors: Jae-Sung Lim, Chulho Kim, Mi Sun Oh, Ju-Hun Lee, San Jung, Min Uk Jang, Sang-Hwa Lee, Yeo Jin Kim, Yerim Kim, Sang Won Suh, Byung-Chul Lee, Kyung-Ho Yu Source Type: research

Factors associated with preservation of C-peptide levels at the diagnosis of type 1 diabetes
The level of C-peptide can identify individuals most likely to respond to immune interventions carried out to prevent pancreatic β-cell damage.The aim of the study was to evaluate factors associated with C-peptide levels at type 1 diabetes (T1D) diagnosis. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 26, 2018 Category: Endocrinology Authors: Agnieszka Szypowska, Lidia Groele, Marta Wysocka-Mincewicz, Artur Mazur, Lucyna Lisowicz, Iwona Ben-Skowronek, Joanna Sieniawska, Bo żenna Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Klaudyna Noiszewska, Beata Pyrżak Source Type: research

Glycemic control is an important modifiable risk factor for uveitis in patients with diabetes: A retrospective cohort study establishing clinical risk and ophthalmic disease burden
To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 26, 2018 Category: Endocrinology Authors: Abdus Samad Ansari, Simon de Lusignan, William Hinton, Neil Munro, Simon Taylor, Andrew McGovern Source Type: research

Potential mechanisms underlying differences in the effect of incretin-based antidiabetic drugs on the risk of major atherosclerotic ischemic events
Incretin-based drugs exert antihyperglycemic effects in type 2 diabetes by mimicking or potentiating the effects of glucagon-like peptide-1 (GLP-1), which acts on the pancreas to stimulate the release of insulin. Long-acting GLP-1 receptor agonists (e.g., exenatide, liraglutide and semaglutide) are resistant to endogenous degradation and produce prolonged stimulation of the GLP-1 receptor. Conversely, drugs that inhibit dipeptidyl peptidase-4 (DPP-4) (e.g., sitagliptin and saxagliptin) enhance the actions of endogenous GLP-1 and may also augment non-GLP-1 peptides that are normally degraded by DPP-4. (Source: Journal of Di...
Source: Journal of Diabetes and Its Complications - March 26, 2018 Category: Endocrinology Authors: Milton Packer Source Type: research

Factors associated with preservation of C-peptide levels at the diagnosis of type 1 diabetes.
The level of C-peptide is one of the biomarkers that can identify individuals most likely to respond to immune interventions carried out to prevent pancreatic β-cell damage.The aim of the current study was to evaluate factors associated with C-peptide levels at type 1 diabetes (T1D) diagnosis. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 26, 2018 Category: Endocrinology Authors: Agnieszka Szypowska, Lidia Groele, Marta Wysocka-Mincewicz, Artur Mazur, Lucyna Lisowicz, Iwona Ben-Skowronek, Joanna Sieniawska, Bo żena Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Klaudyna Noiszewska, Beata Pyrżak, Source Type: research

Understanding the relationship between diabetes, retinopathy, glycaemic control, acute uveitis, and scleritis or episcleritis: A cohort database study
Acute uveitis and scleritis or episcleritis as categorised by anatomical site of inflammation; are most frequently idiopathic or linked to systemic disease. We characterised the risk of these conditions in relation to type of diabetes, level of glycaemic control, and co-existence of retinopathy. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 26, 2018 Category: Endocrinology Authors: Abdus Samad Ansari, Simon de Lusignan, William Hinton, Neil Munro, Simon Taylor, Andrew McGovern Source Type: research

Potential Mechanisms Underlying Differences in the Effect of Incretin-Based Antidiabetic Drugs on the Risk of Major Atherosclerotic Ischemic Events
Incretin-based drugs exert antihyperglycemic effects in type 2 diabetes by mimicking or potentiating the effects of glucagon-like peptide-1 (GLP-1), which acts on the pancreas to stimulate the release of insulin. Long-acting GLP-1 receptor agonists (e.g., exenatide, liraglutide and semaglutide) are resistant to endogenous degradation and produce prolonged stimulation of the GLP-1 receptor. Conversely, drugs that inhibit dipeptidyl peptidase-4 (DPP-4) (e.g., sitagliptin and saxagliptin) enhance the actions of endogenous GLP-1 and may also augment non-GLP-1 peptides that are normally degraded by DPP-4. (Source: Journal of Di...
Source: Journal of Diabetes and Its Complications - March 26, 2018 Category: Endocrinology Authors: Milton Packer Source Type: research

Short-term metabolic control and sleep in children and adolescents with type 1 diabetes mellitus
The aim of this study was to examine sleep in T1D children and in healthy controls by polysomnographic (PSG) examination and to determine the influence of short-term metabolic compensation on sleep quality and sleep disordered breathing (SDB). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 22, 2018 Category: Endocrinology Authors: Martina Kostkov á, Peter Ďurdík, Miriam Čiljaková, Jarmila Vojtková, Anna Šujanská, Katarína Pozorčiaková, Zuzana Sňahničanová, Mária Jančinová, Peter Bánovčin Source Type: research

New-Onset Diabetes After Androgen-Deprivation Therapy For Prostate Cancer: A Nationwide Propensity Score-Matched Four-Year Longitudinal Cohort Study
Androgen-deprivation therapy (ADT) is important in the treatment of prostate cancer. However, the relationship between ADT and the risk of diabetes remains unclear, and the association between duration and types of ADT has not been fully investigated.AimTo examine the risk of developing type 2 diabetes mellitus (T2DM) in men who underwent ADT for prostate cancer. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - March 22, 2018 Category: Endocrinology Authors: Jhen-Hao Jhan, Hsin-Chih Yeh, Yu-Han Chang, Shiao-Jin Guu, Wen-Jeng Wu, Yii-Her Chou, Ching-Chia Li Source Type: research

Increased urinary albumin excretion in children with type 1 diabetes: is it a reason for concern?
Numerous studies have reported on the prevalence of microalbuminuria among children with type 1 diabetes,1 –6 suggesting that the rates of persistent microalbuminuria range from 4.4% to 8.6% with 5–6 years of diabetes duration. However, investigations on incidence rates, especially for persistent microalbuminuria, are less common. In the current issue of the Journal of Diabetes and Its Complication s, Dr. d'Annunzio and colleagues sought to determine the incidence of persistently increased albuminuria in a clinic-based pediatric cohort of type 1 diabetes followed prospectively from diagnosis. (Source: Journal of Diab...
Source: Journal of Diabetes and Its Complications - March 22, 2018 Category: Endocrinology Authors: Tina Costacou Source Type: research

Increased urinary albumin excretion in children with type 1 diabetes: is it a reason for concern?
Numerous studies have reported on the prevalence of microalbuminuria among children with type 1 diabetes,1 –6 suggesting that the rates of persistent microalbuminuria range from 4.4% to 8.6% with 5-6 years of diabetes duration. However, investigations on incidence rates, especially for persistent microalbuminuria, are less common. In the current issue of the Journal of Diabetes and Its Complications, D r. d’Annunzio and colleagues sought to determine the incidence of persistently increased albuminuria in a clinic-based pediatric cohort of type 1 diabetes followed prospectively from diagnosis. (Source: Journal of Diabet...
Source: Journal of Diabetes and Its Complications - March 22, 2018 Category: Endocrinology Authors: Tina Costacou Source Type: research