Continuous Glucose Monitoring adds Information Beyond HbA1c in Well-Controlled Diabetes Patients with Early Cardiovascular Autonomic Neuropathy
Hyperglycemia as evaluated by HbA1c is a risk factor for the development of cardiovascular autonomic neuropathy (CAN). The aim of the present study was to investigate whether continuous glucose monitoring (CGM) may add information beyond HbA1c in patients with type 2 diabetes and CAN. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 30, 2017 Category: Endocrinology Authors: Jesper Fleischer, Esben Laugesen, Simon Lebech Cichosz, Pernille Hoeyem, Thomas Fremming Dejgaard, Per Loegstrup Poulsen, Lise Tarnow, Troels Krarup Hansen Source Type: research

Matrix Gla protein T-138C polymorphism is associated with carotid intima media thickness and predicts mortality in patients with diabetic nephropathy
We sought to determine the predictive value of Matrix Gla Protein MGP T-138C polymorphism in relation to all-cause mortality, cardiovascular mortality and cardiovascular events in patients with diabetic nephropathy (DN). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 29, 2017 Category: Endocrinology Authors: Stefanos Roumeliotis, Athanasios Roumeliotis, Stylianos Panagoutsos, Efstathia Giannakopoulou, Nikolaos Papanas, Vangelis G. Manolopoulos, Ploumis Passadakis, Anna Tavridou Source Type: research

Hydrogen sulfide improves diabetic wound healing in ob/ob mice via attenuating inflammation
The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H2S) has been reported to have multiple biological activities. We aim to investigate the role of H2S in impaired wound healing in ob/ob mice and explore the possible mechanisms involved. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 29, 2017 Category: Endocrinology Authors: Huichen Zhao, Shengxia Lu, Jiachao Chai, Yuchao Zhang, Xiaoli Ma, Jicui Chen, Qingbo Guan, Meiyan Wan, Yuantao Liu Source Type: research

Evaluation of Urinary Autophagy Transcripts Expression in Diabetic Kidney Disease
We identified and validated novel urinary autophagy markers in diabetic kidney disease(DKD) based on bioinformatics analysis and clinical validation. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 27, 2017 Category: Endocrinology Authors: Marwa Matboli, Ahmed E.M. Azazy, Seham Adel, Miram M. Bekhet, Sanaa Eissa Source Type: research

Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial
This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with DFU. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 27, 2017 Category: Endocrinology Authors: Zahra Soleimani, Fatemeh Hashemdokht, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi Source Type: research

Clinical characteristics, beta-cell dysfunction and treatment outcomes in patients with A −β+ Ketosis-Prone Diabetes (KPD): The first identified cohort amongst Asian Indians
The objectives of this study were to look into the clinical characteristics of adult Asian Indian patients with recently diagnosed, antibody negative diabetes presenting with unprovoked ketoacidosis (A −β+ KPD) and to determine the natural course of recovery of beta-cell functions on serial follow-up over one year. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 22, 2017 Category: Endocrinology Authors: Riddhi Das Gupta, Roshna Ramachandran, Praveen Gangadhara, Shajith Anoop, Surjitkumar H. Singh, Anil Satyaraddi, Samantha Sathyakumar, H.S. Asha, Nihal Thomas Source Type: research

Hand, Shoulder and Back Stiffness in Long-term Type 1 Diabetes; Cross-sectional Association with Skin Collagen Advanced Glycation End-products. The Dialong Study
We aimed to: (i) estimate the prevalence of Dupuytren ’s disease, trigger finger, carpal tunnel syndrome and frozen shoulder; (ii) assess stiffness of the hand, shoulder and back; and (iii) explore the association of joint stiffness with both long-term HbA1c and collagen advanced glycation end-products (AGEs) in long-term type 1 diabetes mellitus (T1 DM). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 22, 2017 Category: Endocrinology Authors: Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kristian Folkvord Hanssen, Dag Sigurd Fosmark, David R. Sell, Vincent M. Monnier, Tore Julsrud Berg Source Type: research

Clinical characteristics,Beta-cell dysfunction and treatment outcomes in patients with A- β+ Ketosis-Prone Diabetes (KPD): the first identified cohort amongst Asian Indians
The objectives of this study were to look into the clinical characteristics of adult Asian Indian patients with recently diagnosed, antibody negative diabetes presenting with unprovoked ketoacidosis(A- β+ KPD) and to determine the natural course of recovery of beta-cell functions on serial follow-up over one year. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 22, 2017 Category: Endocrinology Authors: Riddhi Das Gupta, Roshna Ramachandran, Praveen Gangadhara, Shajith Anoop, Surjitkumar H. Singh, Anil Satyaraddi, Samantha Sathyakumar, H.S. Asha, Nihal Thomas Source Type: research

Three-year efficacy and safety of exenatide once weekly: A pooled analysis of three trials
To evaluate the 3-year efficacy and safety of exenatide once weekly (QW) for type 2 diabetes (T2D) in a large clinical population. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 19, 2017 Category: Endocrinology Authors: Michael E. Trautmann, Luc Van Gaal, Jenny Han, Elise Hardy Source Type: research

Genetics of non-syndromic childhood obesity and the use of high-throughput DNA sequencing technologies
Childhood obesity is a serious public health problem associated with the development of several chronic diseases, such as type 2 diabetes mellitus, dyslipidemia, and hypertension. The elevated prevalence of obesity is mostly due to inadequate diet and lifestyle, but it is also influenced by genetic factors. Common obesity, which represents the most prevalent cases, is a multifactorial and polygenic disease. However, different studies reported that single gene variants cause Mendelian forms of obesity, determined by mutations of major effect in single genes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 16, 2017 Category: Endocrinology Authors: Ana Carolina Proen ça da Fonseca, Claudio Mastronardi, Angad Johar, Mauricio Arcos-Burgos, Gilberto Paz-Filho Tags: Review article Source Type: research

The Futile Cycle of Hospital Readmission in Patients with Diabetes
In 2012, the Centers for Medicare and Medicaid Services (CMS) began reducing Medicare payments to hospitals with higher than expected readmissions within 30 days of discharge.1 This led to focused efforts at many institutions for identifying patients at high risk for readmission and introducing programs to ameliorate this risk.2 Current estimates indicate that 25% of patients hospitalized in the US have diabetes as a primary or secondary diagnosis.3,4 Approximately 10-20% of patients with diabetes are readmitted within 30 days of hospital discharge, with higher rates of readmission observed in those with more comorbidities...
Source: Journal of Diabetes and Its Complications - June 16, 2017 Category: Endocrinology Authors: Janya Swami, Mary Korytkowski Source Type: research

Cancer risks of anti-hyperglycemic drugs for type 2 diabetes treatment – a clinical appraisal
A clinical appraisal of existing scientific literature sought to assess the need for long-term prospective epidemiological studies to investigate an increased cancer risk of anti-hyperglycemic medication in type 2 diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 15, 2017 Category: Endocrinology Authors: Jiten Vora, Kausik Ray, Mikhail Kosiborod, Neil R. Poulter, Sanjay Rajagopalan, Lawrence A. Leiter Source Type: research

Cancer risks of anti-hyperglycemic drugs for type 2 diabetes treatment- a clinical appraisal
A clinical appraisal of existing scientific literature sought to assess the need for long-term prospective epidemiological studies to investigate an increased cancer risk of anti-hyperglycemic medication in type 2 diabetes. A focus statement was formulated as: “With a higher risk of cancers in patients with type 2 diabetes, all anti-hyperglycemic drugs should undergo long-term, prospective epidemiological studies for cancer risks.” Field surveys were sent to practicing physicians and endocrinologists to identify the currently prevalent level of accept ance of this statement. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 15, 2017 Category: Endocrinology Authors: Jiten Vora, Kausik Ray, Mikhail Kosiborod, Neil R. Poulter, Sanjay Rajagopalan, Lawrence A. Leiter Tags: Review article Source Type: research

Re: Subclinical thyroid dysfunction and mortality in type 2 diabetes
Although there are inconsistencies between studies, available evidence suggests that subclinical hypothyroidism1 and subclinical hyperthyroidism2 increase the risk of cardiovascular disease (CVD) and death in the general population. There are, however, few diabetes-specific data. In a study of 382 women with type 2 diabetes from the Fremantle Diabetes Study (FDS), of whom 29.6% died during a mean nine-year follow-up, we found no relationship between subclinical hypothyroidism and death (CVD or all-cause), but there was a suggestion that subclinical hyperthyroidism increased all-cause mortality. (Source: Journal of Diabetes...
Source: Journal of Diabetes and Its Complications - June 15, 2017 Category: Endocrinology Authors: Imran Badshah, S.A. Paul Chubb, Wendy A. Davis, Timothy M.E. Davis Tags: Letter to the editor Source Type: research

Contents
(Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 13, 2017 Category: Endocrinology Source Type: research