Genetics of non-syndromic childhood obesity and the use of high-throughput DNA sequencing technologies

Childhood obesity is a serious public health problem associated with the development of several chronic diseases, such as type 2 diabetes mellitus, dyslipidemia, and hypertension. The elevated prevalence of obesity is mostly due to inadequate diet and lifestyle, but it is also influenced by genetic factors. Common obesity, which represents the most prevalent cases, is a multifactorial and polygenic disease. However, different studies reported that single gene variants cause Mendelian forms of obesity, determined by mutations of major effect in single genes.
Source: Journal of Diabetes and Its Complications - Category: Endocrinology Authors: Tags: Review article Source Type: research