The Impact of Non-Severe Hypoglycemia on Quality of Life in Patients with Type 2 Diabetes
To determine the impact of frequency of non-severe hypoglycemic events (NSHE) and the perceived burden of NSHE on quality of life (QOL) over time. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - February 3, 2018 Category: Endocrinology Authors: W.H. Polonsky, L. Fisher, D. Hessler Source Type: research

The effect of increasing tertiles of waist circumference on cardio-metabolic risk, adipokines and biomarkers of inflammation and oxidative stress in nascent metabolic syndrome
The effect of waist circumference (WC) on cardio-metabolic features and biomarkers of oxidative stress and inflammation and adipose tissue dysregulation is poorly defined in Metabolic Syndrome (MetS). Hence the aim of this study was to examine the effect of increasing tertiles of WC on the cardio metabolic risk profile, pro-oxidant state, pro-inflammatory state and adipose tissue dysregulation in nascent MetS patients (n  = 59) without diabetes or CVD. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - February 3, 2018 Category: Endocrinology Authors: Ishwarlal Jialal, Ganesh Jialal, Sridevi Devaraj, Beverley Adams-Huet Source Type: research

Clustering of microvascular complications in type 1 diabetes mellitus
To describe to what extent microvascular complications exhibit clustering in persons with Type 1 diabetes, and to assess whether the presence of one complication modified the strength of the association between the other two. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - February 3, 2018 Category: Endocrinology Authors: Lasse Bjerg, Adam Hulman, Morten Charles, Marit Eika J ørgensen, Daniel Rinse Witte Source Type: research

Diabetes status is linked to low health literacy: Implications for health system
Numerous clinic- based studies over the last 25  years have found an association between health literacy and patients' diabetes knowledge, distress, self- confidence, self- management behavior, glycemic control and health outcomes.1–8 In this issue of the Journal of Diabetes and Its Complications, Dr. Quartuccio and colleagues sought to deter mine if lower health literacy was associated with diabetes and/or hyperglycemia in older adults and if this relationship differed by sex.9 The study is unique in that it across sectional analysis from the Health Aging and Body Composition (ABC) study, a 20-year longitudinal cohort...
Source: Journal of Diabetes and Its Complications - February 3, 2018 Category: Endocrinology Authors: Terry Davis Source Type: research

An expanded prevention quality diabetes composite: Quantifying the burden of preventable hospitalizations for older adults with diabetes
To expand the existing United States Agency for Health Research and Quality (AHRQ) Diabetes composite (AHRQ-DC) to include additional preventable hospitalizations specific or relevant to diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - February 1, 2018 Category: Endocrinology Authors: Chin-Lin Tseng, Orysya Soroka, Leonard M. Pogach Source Type: research

An Expanded Prevention Quality Diabetes Composite: Quantifying the Burden of Preventable Hospitalizations for Older Adults with Diabetes
To expand the existing United States Agency for Health Research and Quality (AHRQ) Diabetes composite (AHRQ-DC) to include additional preventable hospitalizations specific or relevant to diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - February 1, 2018 Category: Endocrinology Authors: Chin-Lin Tseng, Orysya Soroka, Leonard M. Pogach Source Type: research

Serum apolipoprotein A-1 concentrations and the prevalence of cardiovascular autonomic neuropathy in individuals with type 2 diabetes
To evaluate the relationship between levels of serum apolipoproteins and the prevalence of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - January 21, 2018 Category: Endocrinology Authors: Jin Ook Chung, Seon-Young Park, Ji Hyun Han, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung Source Type: research

Metabolomic profiling of women with gestational diabetes mellitus and their offspring: Review of metabolomics studies
Gestational diabetes mellitus (GDM) reflects an increased risk of developing type 2 diabetes (T2D) after pregnancy in women. Offspring born to mothers with GDM are at an elevated risk of obesity and T2D at a young age. Currently, there are lack of ways for identifying women in early pregnancy who are at risk of developing GDM. As a result, both mothers and fetus are not treated until late in the second trimester when GDM is diagnosed. The recent advance in metabolomics, a new approach of systematic investigation of the metabolites, provides an opportunity for early detection of GDM, and classifying the risk of subsequent c...
Source: Journal of Diabetes and Its Complications - January 19, 2018 Category: Endocrinology Authors: Qian Chen, Ellen Francis, Gang Hu, Liwei Chen Source Type: research

Metabolomic profiling of women with gestational diabetes mellitus and their offspring: Review of metabolomics studies
Gestational diabetes mellitus (GDM) reflects an increased risk of subsequently developing type 2 diabetes (T2D) after pregnancy in women. Offspring born to mothers with GDM are at an elevated risk of developing obesity and T2D at a young age. Currently, there are a lack of tools with high sensitivity and high specificity capable of identifying women in early pregnancy who are at risk of developing GDM. As a result, both mothers and fetus are not treated until late in the second trimester when GDM is diagnosed. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - January 19, 2018 Category: Endocrinology Authors: Qian Chen, Ellen Francis, Gang Hu, Liwei Chen Tags: Review article Source Type: research

Measurement of psychological adjustment to diabetes with the diabetes acceptance scale
To develop a psychometric measure of diabetes acceptance. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - January 17, 2018 Category: Endocrinology Authors: Andreas Schmitt, Andr é Reimer, Bernhard Kulzer, Andrea Icks, Rainer Paust, Klaus-Martin Roelver, Matthias Kaltheuner, Dominic Ehrmann, Michael Krichbaum, Thomas Haak, Norbert Hermanns Source Type: research

Transmission disequilibrium of rs4809957 in type 2 diabetes mellitus families and its association with vitamin D deficiency: A family-based case –control study
Association between T2DM and vitamin D was found in many epidemiologic reports. And 24-hydroxylase encoded by CYP24A1 is the very enzyme that degrades the active vitamin D metabolite. We aimed to investigate the association between rs4809957 in CYP24A1 and T2DM, as well as vitamin D level. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - January 11, 2018 Category: Endocrinology Authors: Songcheng Yu, Xing Li, Yan Wang, Zhenxing Mao, Chongjian Wang, Yue Ba, Wenjie Li Source Type: research

Trends in cardiovascular risk factor management in type 1 diabetes by sex
DCCT showed that intensive type 1 diabetes management reduces complication incidence but did not focus on other cardiovascular disease risk factors, whose control in type 1 diabetes has not been well-studied. We assessed trends in cardiovascular risk factors in type 1 diabetes and attainment of concurrent American Diabetes Association (ADA) guidelines/recommendations (for HbA1c, blood pressure, LDL cholesterol, triglycerides) for complication prevention. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - January 10, 2018 Category: Endocrinology Authors: Krystal K. Swasey, Trevor J. Orchard, Tina Costacou Source Type: research

Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort
To test the hypothesis that multitissue deficits in insulin sensitivity are greater among women than men with type 1 diabetes compared to respective controls. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - January 9, 2018 Category: Endocrinology Authors: Richard J. Millstein, Laura L. Pyle, Bryan C. Bergman, Robert H. Eckel, David M. Maahs, Marian J. Rewers, Irene E. Schauer, Janet K. Snell-Bergeon Source Type: research

Identifying the Causes of the Changes in the Prevalence Patterns of Diabetes in Older U.S. Adults: A New Trend Partitioning Approach
To identify how efforts to control the diabetes epidemic and the resulting changes in diabetes mellitus, type II (T2D) incidence and survival have affected the time-trend of T2D prevalence. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - January 6, 2018 Category: Endocrinology Authors: Igor Akushevich, Arseniy P. Yashkin, Julia Kravchenko, Fang Fang, Konstantin Arbeev, Frank Sloan, Anatoliy I. Yashin Source Type: research

Macronutrient intake and oxidative stress/inflammation in type 1 diabetes
The association of oxidative stress and inflammation with diabetes, both type 1 and type 2, has been established for a long time.1 –6 Thus, increased lipid peroxidation with an increase in TBARS was the first evidence of oxidative stress.7,8 The occurrence of oxidative damage to DNA and protein carbonylation in both type 1 and type 2 diabetes was first described by Dandona et al.9 One of the known mechanisms related to the in duction of oxidative stress and inflammation is macronutrient intake, especially carbohydrates and fats. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - January 5, 2018 Category: Endocrinology Authors: Paresh Dandona, Husam Ghanim Source Type: research