Metformin and Vitamin B12- what ’s missing from this picture?

Over the past several years, increasing attention has been paid to the association of chronic metformin treatment with low levels of vitamin B12. Anecdotal reports of the association, thought to be due to impaired B12 absorption from the gastrointestinal track, have been available for decades. More recently, some well-designed studies, including two randomized clinical trials, have more clearly documented the magnitude and time frame of the risk12.3 As a result, periodic measurement of B12 levels in metformin treated patients is now recommended.
Source: Journal of Diabetes and Its Complications - Category: Endocrinology Authors: Source Type: research