Challenges in defining, diagnosing, and treating diabetic gastroparesis

Gastroparesis is a highly symptomatic, multi-factorial disorder characterized by nausea, vomiting, early satiety, abdominal pain, and bloating, in combination with delayed gastric emptying without obstruction.1 Although the incidence is relatively low in the general population, individuals with diabetes have a substantially increased risk of developing gastroparesis, reported as being over 7-times higher risk for type 2 diabetes, and 30-times higher risk for type 1 diabetes.2 These associations are explained by several factors, including oxidative stress on the interstitial cells of Cajal (ICC), autonomic neuropathy and impaired neurotransmission, smooth muscle atrophy, and impaired antropyloric / duodenal coordination.
Source: Journal of Diabetes and Its Complications - Category: Endocrinology Authors: Source Type: research