Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post Hoc Analysis of a randomized controlled 4.3 year trial

Metformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial. We studied the effects of metformin on serum levels of methylmalonic acid (MMA), a biomarker for tissue B12 deficiency, and on onset or progression of neuropathy.
Source: Journal of Diabetes and Its Complications - Category: Endocrinology Authors: Source Type: research