Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice

Low levels of reactive oxygen species and resulting oxidative protein modifications may play a beneficial role in cellular function under stress conditions. Here we studied the influence of age-dependent protein carbonylation on expression and activity of the anti-oxidative selenoenzyme glutathione peroxidase (GPx) in insulin-deficient Ins2Akita mice and type 2 diabetic obese db/db mice in context of diabetic nephropathy.

Source: Journal of Diabetes and Its Complications - November 21, 2017 Category: Endocrinology Authors: Tanja Wiedenmann, Nadine Dietrich, Thomas Fleming, Sandro Altamura, Leo E. Deelman, Rob H. Henning, Martina U. Muckenthaler, Peter P. Nawroth, Hans-Peter Hammes, Andreas H. Wagner, Markus Hecker Source Type: research