Continuing To Smoke After Breast Cancer Diagnosis Lowers Survival Rate
(Source: JNCI)
Source: JNCI - June 1, 2016 Category: Cancer & Oncology Authors: Fillon, M. Tags: News Source Type: research
Shock Therapy for Late-Stage Pancreatic Cancer Gets Closer Look
(Source: JNCI)
Source: JNCI - June 1, 2016 Category: Cancer & Oncology Authors: Jenks, S. Tags: News Source Type: research
PDQ (Physician Data Query)
(Source: JNCI)
Source: JNCI - June 1, 2016 Category: Cancer & Oncology Tags: News Source Type: research
Dose Schedules Inspired by Evolutionary Concepts Lengthen Progression-Free Survival in Mice
(Source: JNCI)
Source: JNCI - June 1, 2016 Category: Cancer & Oncology Authors: Schmidt, C. Tags: News Source Type: research
Current and Evolving Methods to Visualize Biological Data in Cancer Research
Although the measurements of clinical outcomes for cancer treatments have become diverse and complex, there remains a need for clear, easily interpreted representations of patients’ experiences. With oncology trials increasingly reporting non-time-to-event outcomes, data visualization has evolved to incorporate parameters such as responses to therapy, duration and degree of response, and novel representations of underlying tumor biology. We review both commonly used and newly developed methods to display outcomes in oncology, with a focus on those that have evolved to represent complex datasets. (Source: JNCI)
Source: JNCI - May 30, 2016 Category: Cancer & Oncology Authors: Chia, P. L., Gedye, C., Boutros, P. C., Wheatley-Price, P., John, T. Tags: Review Source Type: research
Adjuvant Radiation Therapy and Chemotherapy in Merkel Cell Carcinoma: Survival Analyses of 6908 Cases From the National Cancer Data Base
Conclusions: In this study of the largest MCC cohort reported to date, adjuvant RT was associated with improved OS in stages I-II MCC. Neither adjuvant RT nor chemotherapy was associated with improved OS in stage III MCC. These results, with the limitations of retrospective analyses, are consistent with earlier studies suggesting benefit with adjuvant RT but do not support the routine use of adjuvant chemotherapy in MCC. (Source: JNCI)
Source: JNCI - May 30, 2016 Category: Cancer & Oncology Authors: Bhatia, S., Storer, B. E., Iyer, J. G., Moshiri, A., Parvathaneni, U., Byrd, D., Sober, A. J., Sondak, V. K., Gershenwald, J. E., Nghiem, P. Tags: Article Source Type: research
Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression
Conclusions: Agents targeting nuclear kinases appear to be effective in SCLC lines. Confirmation of SCLC line findings in xenografts is needed. The drug and compound response, gene expression, and microRNA expression data are publicly available at http://sclccelllines.cancer.gov. (Source: JNCI)
Source: JNCI - May 30, 2016 Category: Cancer & Oncology Authors: Polley, E., Kunkel, M., Evans, D., Silvers, T., Delosh, R., Laudeman, J., Ogle, C., Reinhart, R., Selby, M., Connelly, J., Harris, E., Fer, N., Sonkin, D., Kaur, G., Monks, A., Malik, S., Morris, J., Teicher, B. A. Tags: Article Source Type: research
Developing New, Rational Therapies for Recalcitrant Small Cell Lung Cancer
(Source: JNCI)
Source: JNCI - May 30, 2016 Category: Cancer & Oncology Authors: Gazdar, A. F., Minna, J. D. Tags: Editorial Source Type: research
De Novo vs Nevus-Associated Melanomas: Differences in Associations With Prognostic Indicators and Survival
Conclusions: These data suggest that de novo melanomas are more aggressive than nevus-associated melanomas. This classification scheme may also provide a useful framework for investigations into sex differences in melanoma outcomes. (Source: JNCI)
Source: JNCI - May 26, 2016 Category: Cancer & Oncology Authors: Cymerman, R. M., Shao, Y., Wang, K., Zhang, Y., Murzaku, E. C., Penn, L. A., Osman, I., Polsky, D. Tags: Article Source Type: research
Comparison of Eligibility Criteria Between Protocols, Registries, and Publications of Cancer Clinical Trials
Trial registration and public accessibility of appended or published protocols of phase III randomized clinical trials (RCTs) allow comparison of reported research with essential aspects of trial design. We determined how eligibility criteria of participants specified in protocols were described in trial registries and articles of 255 cancer RCTs published in leading journals. The mean proportion of matching eligibility criteria between protocols and publications per trial (the primary endpoint) was 44.0% (95% confidence interval [CI] = 40.8% to 47.3%). Almost all discrepancies in eligibility criteria (96.7%, 95% CI = 96.1...
Source: JNCI - May 24, 2016 Category: Cancer & Oncology Authors: Zhang, S., Liang, F., Li, W., Tannock, I. Tags: Brief Communication Source Type: research
Lung Cancer Patient Outcomes Better At High-Volume Treatment Centers Than Low-Volume Treatment Centers
(Source: JNCI)
Source: JNCI - May 18, 2016 Category: Cancer & Oncology Tags: Memo to the Media Source Type: research
Institutional Enrollment and Survival Among NSCLC Patients Receiving Chemoradiation: NRG Oncology Radiation Therapy Oncology Group (RTOG) 0617
Conclusion: Treatment at institutions with higher clinical trial accrual volume is associated with longer OS among patients with LA-NSCLC participating in a phase III trial. (Source: JNCI)
Source: JNCI - May 18, 2016 Category: Cancer & Oncology Authors: Eaton, B. R., Pugh, S. L., Bradley, J. D., Masters, G., Kavadi, V. S., Narayan, S., Nedzi, L., Robinson, C., Wynn, R. B., Koprowski, C., Johnson, D. W., Meng, J., Curran, W. J. Tags: Article Source Type: research
RE: Serum Lipids, Lipoproteins, and Risk of Breast Cancer: A Nested Case-Control Study Using Multiple Time Points
(Source: JNCI)
Source: JNCI - May 17, 2016 Category: Cancer & Oncology Authors: Martin, L. J., Huszti, E., Connelly, P. W., Greenberg, C. V., Minkin, S., Boyd, N. F. Tags: Correspondence Source Type: research
Evaluating Markers for Guiding Treatment
Conclusions: Because the method has desirable decision-analytic properties and yields an informative plot, it is worth applying to randomized trials on the chance there is a large treatment effect in a subgroup determined by the predictive markers. (Source: JNCI)
Source: JNCI - May 17, 2016 Category: Cancer & Oncology Authors: Baker, S. G., Bonetti, M. Tags: Article Source Type: research
Endogenous Estrogens, Estrogen Metabolites, and Breast Cancer Risk in Postmenopausal Chinese Women
Conclusions: Lower urinary parent estrogen concentrations and more extensive 2-hydroxylation were each associated with reduced postmenopausal breast cancer risk in a low-risk nation. Markedly higher total estrogen/estrogen metabolite concentrations in postmenopausal United States women (Asian Americans) than in Shanghai women may partly explain higher breast cancer rates in the United States. (Source: JNCI)
Source: JNCI - May 17, 2016 Category: Cancer & Oncology Authors: Moore, S. C., Matthews, C. E., Ou Shu, X., Yu, K., Gail, M. H., Xu, X., Ji, B.-T., Chow, W.-H., Cai, Q., Li, H., Yang, G., Ruggieri, D., Boyd-Morin, J., Rothman, N., Hoover, R. N., Gao, Y.-T., Zheng, W., Ziegler, R. G. Tags: Article Source Type: research
