Chronic Conditions and Utility-Based Health-Related Quality of Life in Adult Childhood Cancer Survivors
Health utility, a summary measure of quality of life, has not been previously used to compare outcomes among childhood cancer survivors and individuals without a cancer history. We estimated health utility (0, death; 1, perfect health) using the Short Form-6D (SF-6D) in survivors (n = 7105) and siblings of survivors (n = 372) (using the Childhood Cancer Survivor Study cohort) and the general population (n = 12 803) (using the Medical Expenditures Panel Survey). Survivors had statistically significantly lower SF-6D scores than the general population (mean = 0.769, 95% confidence interval [CI] = 0.766 to 0.771, vs mean = 0.8...
Source: JNCI - April 20, 2016 Category: Cancer & Oncology Authors: Yeh, J. M., Hanmer, J., Ward, Z. J., Leisenring, W. M., Armstrong, G. T., Hudson, M. M., Stovall, M., Robison, L. L., Oeffinger, K. C., Diller, L. Tags: Brief Communication Source Type: research
Lapatinib-Related Rash and Breast Cancer Outcome in the ALTTO Phase III Randomized Trial
Conclusions: Our results indicate that early development of rash identifies patients who derive superior benefit from lapatinib-based therapy. (Source: JNCI)
Source: JNCI - April 19, 2016 Category: Cancer & Oncology Authors: Sonnenblick, A., de Azambuja, E., Agbor-tarh, D., Bradbury, I., Campbell, C., Huang, Y., Dueck, A. C., Pritchard, K. I., Wolff, A. C., Jackisch, C., Lang, I., Untch, M., Smith, I., Boyle, F., Xu, B., Gomez, H., Perez, E. A., Piccart, M., Azim, H. A. Tags: Article Source Type: research
Erratum
(Source: JNCI)
Source: JNCI - April 12, 2016 Category: Cancer & Oncology Tags: Erratum Source Type: research
Association Between Hepatitis C Virus and Head and Neck Cancers
Conclusions: HCV is associated with nonoropharyngeal (except nasopharyngeal) and HPV-positive oropharyngeal HNCs. Further studies are required to explore the possible interaction between HCV and HPV, and the association between HCV and other HPV-related malignancies. (Source: JNCI)
Source: JNCI - April 12, 2016 Category: Cancer & Oncology Authors: Mahale, P., Sturgis, E. M., Tweardy, D. J., Ariza-Heredia, E. J., Torres, H. A. Tags: Article Source Type: research
Response
(Source: JNCI)
Source: JNCI - April 12, 2016 Category: Cancer & Oncology Authors: Hermelink, K., Bühner, M., Harbeck, N. Tags: Response Source Type: research
RE: Elucidating Pretreatment Cognitive Impairment in Breast Cancer Patients: The Impact of Cancer-Related Post-traumatic Stress
(Source: JNCI)
Source: JNCI - April 12, 2016 Category: Cancer & Oncology Authors: Sepehry, A. A., Tyldesley, S., Davis, M. K., Simmons, C., Rauscher, A., Lang, D. J.-M. Tags: Correspondence Source Type: research
Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer
Conclusions: Thus, fucose-bound liposomes carrying anticancer drugs provide a new strategy for the treatment of CRC patients. (Source: JNCI)
Source: JNCI - April 12, 2016 Category: Cancer & Oncology Authors: Osuga, T., Takimoto, R., Ono, M., Hirakawa, M., Yoshida, M., Okagawa, Y., Uemura, N., Arihara, Y., Sato, Y., Tamura, F., Sato, T., Iyama, S., Miyanishi, K., Takada, K., Hayashi, T., Kobune, M., Kato, J. Tags: Article Source Type: research
Targeting a Cancer-Specific Epitope of the Epidermal Growth Factor Receptor in Triple-Negative Breast Cancer
Conclusions: These data support the further development of the 806-PE38 immunotoxin as a therapeutic agent for the treatment of patients with EGFR-positive TNBC. Follow-up experiments with combination therapies will be attempted to achieve full remissions. (Source: JNCI)
Source: JNCI - April 12, 2016 Category: Cancer & Oncology Authors: Simon, N., Antignani, A., Sarnovsky, R., Hewitt, S. M., FitzGerald, D. Tags: Article Source Type: research
miR-141-Mediated Regulation of Brain Metastasis From Breast Cancer
Conclusions: Our study suggests miR-141 is a regulator of brain metastasis from breast cancer and should be examined as a biomarker and potential target to prevent and treat brain metastases. (Source: JNCI)
Source: JNCI - April 12, 2016 Category: Cancer & Oncology Authors: Debeb, B. G., Lacerda, L., Anfossi, S., Diagaradjane, P., Chu, K., Bambhroliya, A., Huo, L., Wei, C., Larson, R. A., Wolfe, A. R., Xu, W., Smith, D. L., Li, L., Ivan, C., Allen, P. K., Wu, W., Calin, G. A., Krishnamurthy, S., Zhang, X. H., Buchholz, T. A. Tags: Article Source Type: research
Table_of_Contents
(Source: JNCI)
Source: JNCI - April 11, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: JNCI)
Source: JNCI - April 11, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Cover
(Source: JNCI)
Source: JNCI - April 11, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Associations of Insulin and IGFBP-3 with Lung Cancer Susceptibility in Current Smokers
Conclusions:
Independent of obesity, high insulin levels but reduced levels of IGFBP-3 were associated with increased lung cancer risk in current smokers. (Source: JNCI)
Source: JNCI - April 11, 2016 Category: Cancer & Oncology Authors: Ho, G. Y. F., Zheng, S. L., Cushman, M., Perez-Soler, R., Kim, M., Xue, X., Wang, T., Schlecht, N. F., Tinker, L., Rohan, T. E., Wassertheil-Smoller, S., Wallace, R., Chen, C., Xu, J., Yu, H. Tags: Article Source Type: research
Evidence Showing That Tumors Can Grow Without Angiogenesis and Can Switch Between Angiogenic and Nonangiogenic Phenotypes
(Source: JNCI)
Source: JNCI - April 7, 2016 Category: Cancer & Oncology Authors: Pezzella, F., Gatter, K. C. Tags: Editorial Source Type: research
Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma
Conclusions: This is the first documentation of vessel co-option as a mechanism of acquired resistance to anti-angiogenic therapy and could have important implications including the potential therapeutic benefits of targeting vessel co-option in conjunction with vascular endothelial growth factor receptor signaling. (Source: JNCI)
Source: JNCI - April 7, 2016 Category: Cancer & Oncology Authors: Kuczynski, E. A., Yin, M., Bar-Zion, A., Lee, C. R., Butz, H., Man, S., Daley, F., Vermeulen, P. B., Yousef, G. M., Foster, F. S., Reynolds, A. R., Kerbel, R. S. Tags: Article Source Type: research
