Development of a RNA-Seq Based Prognostic Signature in Lung Adenocarcinoma
Conclusions: Here, we present the first RNA-seq prognostic signature for lung adenocarcinoma that can provide a powerful prognostic tool for precision oncology as part of an integrated RNA-seq clinical sequencing program. (Source: JNCI)
Source: JNCI - October 4, 2016 Category: Cancer & Oncology Authors: Shukla, S., Evans, J. R., Malik, R., Feng, F. Y., Dhanasekaran, S. M., Cao, X., Chen, G., Beer, D. G., Jiang, H., Chinnaiyan, A. M. Tags: Article Source Type: research
Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer
Conclusions: We propose a novel mechanism of immune infiltration in DDRD tumors, independent of neoantigen production. Activation of this pathway and associated PD-L1 expression may explain the paradoxical lack of T-cell-mediated cytotoxicity observed in DDRD tumors. We provide a rationale for exploration of DDRD in the stratification of patients for immune checkpoint–based therapies. (Source: JNCI)
Source: JNCI - October 4, 2016 Category: Cancer & Oncology Authors: Parkes, E. E., Walker, S. M., Taggart, L. E., McCabe, N., Knight, L. A., Wilkinson, R., McCloskey, K. D., Buckley, N. E., Savage, K. I., Salto-Tellez, M., McQuaid, S., Harte, M. T., Mullan, P. B., Harkin, D. P., Kennedy, R. D. Tags: Article Source Type: research
Adjuvant Therapy for Resected Gallbladder Cancer: Analysis of the National Cancer Data Base
Conclusions: The curative potential of current adjuvant therapy in gallbladder cancer is questionable, justifying placebo-controlled investigation of novel chemotherapy combinations or alternative approaches. Chemoradiation may provide a short-term benefit in locally advanced tumors. (Source: JNCI)
Source: JNCI - October 4, 2016 Category: Cancer & Oncology Authors: Mantripragada, K. C., Hamid, F., Shafqat, H., Olszewski, A. J. Tags: Article Source Type: research
Biospecimen Sharing Among Hispanic Women in a Safety-Net Clinic: Implications for the Precision Medicine Initiative
We present results of a study of 140 Hispanic women who underwent a breast biopsy at a safety-net hospital and were randomly assigned to receive information and request for consent for biospecimen and data sharing by the patient’s physician or a research assistant. Consent rates were high (97.1% and 92.9% in the physician and research assistant arms, respectively) and not different between groups (relative risk [RR] = 1.05, 95% confidence interval [CI] = 0.96 to 1.10). Consistent with a small but growing literature, we show that perceptions of Hispanics’ unwillingness to participate in biospecimen sharing for r...
Source: JNCI - September 27, 2016 Category: Cancer & Oncology Authors: Nodora, J. N., Komenaka, I. K., Bouton, M. E., Ohno-Machado, L., Schwab, R., Kim, H.-e., Farcas, C., Perez, G., Elena Martinez, M. Tags: Brief Communication Source Type: research
Different Breast Cancer Treatment Options Vary Widely in their Cost-Effectiveness
(Source: JNCI)
Source: JNCI - September 26, 2016 Category: Cancer & Oncology Tags: Memo to the Media Source Type: research
Cost and Complications of Local Therapies for Early-Stage Breast Cancer
Conclusions: Mastectomy plus reconstruction results in substantially higher complications and cost than other guideline-concordant treatment options for early breast cancer. These findings are relevant to patients evaluating their local therapy options and to value-based population health management. (Source: JNCI)
Source: JNCI - September 26, 2016 Category: Cancer & Oncology Authors: Smith, B. D., Jiang, J., Shih, Y.-C., Giordano, S. H., Huo, J., Jagsi, R., Momoh, A. O., Caudle, A. S., Hunt, K. K., Shaitelman, S. F., Buchholz, T. A., Shirvani, S. M. Tags: Article Source Type: research
Response
(Source: JNCI)
Source: JNCI - September 25, 2016 Category: Cancer & Oncology Authors: Kaye, F. J., Ivey, A. M., Drane, W. E., Mendenhall, W. M., Allan, R. W. Tags: Response Source Type: research
Durable treatment of ameloblastoma with single agent BRAFi Re: Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma
(Source: JNCI)
Source: JNCI - September 25, 2016 Category: Cancer & Oncology Authors: Faden, D. L., Algazi, A. Tags: Correspondence Source Type: research
Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2
Conclusions: The molecular link between PI3K activation and CSC properties found in this study provides insights into therapeutic strategies for HNSCC. Constitutive expression of SOX2 in HNSCC cells generates a CSC-like population that enables CSC studies. (Source: JNCI)
Source: JNCI - September 14, 2016 Category: Cancer & Oncology Authors: Keysar, S. B., Le, P. N., Miller, B., Jackson, B. C., Eagles, J. R., Nieto, C., Kim, J., Tang, B., Glogowska, M. J., Morton, J. J., Padilla-Just, N., Gomez, K., Warnock, E., Reisinger, J., Arcaroli, J. J., Messersmith, W. A., Wakefield, L. M., Gao, D., Ta Tags: Article Source Type: research
Erratum
(Source: JNCI)
Source: JNCI - September 13, 2016 Category: Cancer & Oncology Tags: ERRATUM Source Type: research
Cancer Treatment and Research Under the Affordable Care Act
(Source: JNCI)
Source: JNCI - September 13, 2016 Category: Cancer & Oncology Authors: Schmidt, C. Tags: NEWS Source Type: research
Some HER2-Negative Breast Tumors May Respond to HER2-Targeted Treatment
(Source: JNCI)
Source: JNCI - September 13, 2016 Category: Cancer & Oncology Authors: Rochman, S. Tags: NEWS Source Type: research
Tracking Tumor Resistance: The Early Promise of "Liquid" Cancer Tests
(Source: JNCI)
Source: JNCI - September 13, 2016 Category: Cancer & Oncology Authors: Jenks, S. Tags: NEWS Source Type: research
Targeting Tumors Energy Needs
(Source: JNCI)
Source: JNCI - September 13, 2016 Category: Cancer & Oncology Authors: Azvolinsky, A. Tags: NEWS Source Type: research
Uninsured Rate by State, (1963-2014)
(Source: JNCI)
Source: JNCI - September 13, 2016 Category: Cancer & Oncology Tags: STAT BITE Source Type: research
