Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

Conclusions: The molecular link between PI3K activation and CSC properties found in this study provides insights into therapeutic strategies for HNSCC. Constitutive expression of SOX2 in HNSCC cells generates a CSC-like population that enables CSC studies.

Source: JNCI - September 14, 2016 Category: Cancer & Oncology Authors: Keysar, S. B., Le, P. N., Miller, B., Jackson, B. C., Eagles, J. R., Nieto, C., Kim, J., Tang, B., Glogowska, M. J., Morton, J. J., Padilla-Just, N., Gomez, K., Warnock, E., Reisinger, J., Arcaroli, J. J., Messersmith, W. A., Wakefield, L. M., Gao, D., Ta Tags: Article Source Type: research