Selenium and Prostate Cancer: Analysis of Individual Participant Data From Fifteen Prospective Studies
Conclusions: Nail, but not blood, selenium concentration is inversely associated with risk of total prostate cancer, possibly because nails are a more reliable marker of long-term selenium exposure. Both blood and nail selenium concentrations are associated with a reduced risk of aggressive disease, which warrants further investigation. (Source: JNCI)
Source: JNCI - July 5, 2016 Category: Cancer & Oncology Authors: Allen, N. E., Travis, R. C., Appleby, P. N., Albanes, D., Barnett, M. J., Black, A., Bueno-de-Mesquita, H. B., Deschasaux, M., Galan, P., Goodman, G. E., Goodman, P. J., Gunter, M. J., Heliövaara, M., Helzlsouer, K. J., Henderson, B. E., Hercberg, Tags: Article Source Type: research
Table_of_Contents
(Source: JNCI)
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: JNCI)
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Cover
(Source: JNCI)
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Statins and Reduced Risk of Liver Cancer: Evidence for Confounding
A negative association of statin use with liver cancer risk has been reported frequently. We added laboratory measurements, to our knowledge not included in previous investigations, to a case-control analysis of 2877 case patients and 142 850 matched control subjects enrolled in Kaiser Permanente Northern California. Addressing confounding by indication by restricting subjects to those with elevated cholesterol greatly attenuated the negative association; eg, the multivariable-adjusted odds ratio (OR) rose from 0.41 (95% confidence interval [CI] = 0.35 to 0.49) to 0.87 (95% CI = 0.55 to 1.39) for receipt of 18 or more pres...
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Authors: Friedman, G. D., Achacoso, N., Fireman, B., Habel, L. A. Tags: Brief Communication Source Type: research
Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer
Conclusions: In addition to previously described clinically relevant resistance mechanisms in BRCA1-deficient tumors, we describe a novel resistance mechanism in BRCA1-methylated PDX tumors involving de novo rearrangements at the BRCA1 locus, demonstrating that BRCA1-methylated breast cancers may acquire therapy resistance via both epigenetic and genetic mechanisms. (Source: JNCI)
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Authors: ter Brugge, P., Kristel, P., van der Burg, E., Boon, U., de Maaker, M., Lips, E., Mulder, L., de Ruiter, J., Moutinho, C., Gevensleben, H., Marangoni, E., Majewski, I., Jozwiak, K., Kloosterman, W., van Roosmalen, M., Duran, K., Hogervorst, F., Turner, N. Tags: Article Source Type: research
Ethnic Variations in Estrogen and Its Metabolites: Sufficient to Explain Differences in Breast Cancer Incidence Rates?
(Source: JNCI)
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Authors: Visvanathan, K., Yager, J. D. Tags: Solicited Editorial Source Type: research
The Doppelgänger Effect: Hidden Duplicates in Databases of Transcriptome Profiles
Whole-genome analysis of cancer specimens is commonplace, and investigators frequently share or re-use specimens in later studies. Duplicate expression profiles in public databases will impact re-analysis if left undetected, a so-called "doppelgänger" effect. We propose a method that should be routine practice to accurately match duplicate cancer transcriptomes when nucleotide-level sequence data are unavailable, even for samples profiled by different microarray technologies or by both microarray and RNA sequencing. We demonstrate the effectiveness of the method in databases containing dozens of datasets and thousa...
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Authors: Waldron, L., Riester, M., Ramos, M., Parmigiani, G., Birrer, M. Tags: Brief Communication Source Type: research
Longitudinal Body Composition Changes in Diffuse Large B-cell Lymphoma Survivors: A Retrospective Cohort Study of United States Veterans
Conclusions: DLBCL survivors undergo unfavorable long-term body composition changes. Patients at risk for the long-term development of sarcopenia or visceral obesity can be identified based on clinical risk factors and targeted for lifestyle interventions. (Source: JNCI)
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Authors: Xiao, D. Y., Luo, S., OBrian, K., Sanfilippo, K. M., Ganti, A., Riedell, P., Lynch, R. C., Liu, W., Kahl, B. S., Cashen, A. F., Fehniger, T. A., Carson, K. R. Tags: Article Source Type: research
Role of Myeloma-Derived MIF in Myeloma Cell Adhesion to Bone Marrow and Chemotherapy Response
Conclusions: MIF is an important player and a novel therapeutic target in MM. Inhibiting MIF activity will sensitize MM cells to chemotherapy. (Source: JNCI)
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Authors: Zheng, Y., Wang, Q., Li, T., Qian, J., Lu, Y., Li, Y., Bi, E., Reu, F., Qin, Y., Drazba, J., Hsi, E., Yang, J., Cai, Z., Yi, Q. Tags: Article Source Type: research
Beyond Composite Endpoints Analysis: Semicompeting Risks as an Underutilized Framework for Cancer Research
Conclusions: Embedding and analyzing component outcomes in the semicompeting risks framework, either as a supplement or alternative to CEP analyses, represents an important, underutilized, and feasible opportunity for cancer research. (Source: JNCI)
Source: JNCI - July 4, 2016 Category: Cancer & Oncology Authors: Jazic, I., Schrag, D., Sargent, D. J., Haneuse, S. Tags: Article Source Type: research
RE: RNA Disruption Assay as a Biomarker of Pathological Complete Response in Neoadjuvant Trastuzumab-Treated Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
(Source: JNCI)
Source: JNCI - July 3, 2016 Category: Cancer & Oncology Authors: Toomey, S., Eustace, A. J., Pritzker, L. B., Pritzker, K. P. H., Fay, J., OGrady, A., Cummins, R., Grogan, L., Kennedy, J., OConnor, D., Young, L., Kay, E. W., ODonovan, N., Gallagher, W. M., Kalachand, R., Crown, J., Hennessy, B. T. Tags: Correspondence Source Type: research
Response
(Source: JNCI)
Source: JNCI - July 3, 2016 Category: Cancer & Oncology Authors: Trudeau, M. Tags: Response Source Type: research
Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of t...
Source: JNCI - July 3, 2016 Category: Cancer & Oncology Authors: Ohri, N., Dawson, L. A., Krishnan, S., Seong, J., Cheng, J. C., Sarin, S. K., Kinkhabwala, M., Ahmed, M. M., Vikram, B., Coleman, C. N., Guha, C. Tags: Review Source Type: research
Solutions To Reduce Racial Mistrust
(Source: JNCI)
Source: JNCI - July 1, 2016 Category: Cancer & Oncology Authors: Fillon, M. Tags: News Source Type: research
