The Conundrum of Genetic "Drivers" in Benign Conditions
Advances in deep genomic sequencing have identified a spectrum of cancer-specific passenger and driver aberrations. Clones with driver anomalies are believed to be positively selected during carcinogenesis. Accumulating evidence, however, shows that genomic alterations, such as those in BRAF, RAS, EGFR, HER2, FGFR3, PIK3CA, TP53, CDKN2A, and NF1/2, all of which are considered hallmark drivers of specific cancers, can also be identified in benign and premalignant conditions, occasionally at frequencies higher than in their malignant counterparts. Targeting these genomic drivers can produce dramatic responses in advanced can...
Source: JNCI - April 6, 2016 Category: Cancer & Oncology Authors: Kato, S., Lippman, S. M., Flaherty, K. T., Kurzrock, R. Tags: Review Source Type: research
Stat Bite Percentage of New Prostate Cancer Cases by Age Group, 2008-2012
(Source: JNCI)
Source: JNCI - April 1, 2016 Category: Cancer & Oncology Tags: News Source Type: research
Stat Bite Percentage of New Cases by Age Group For Prostate Cancer (2008-2012)
(Source: JNCI)
Source: JNCI - April 1, 2016 Category: Cancer & Oncology Tags: News Source Type: research
Unraveling How Obesity Fuels Cancer
(Source: JNCI)
Source: JNCI - April 1, 2016 Category: Cancer & Oncology Authors: Azvolinsky, A. Tags: News Source Type: research
Digital Imaging of the Breast: Is a Synthetic View Better?
(Source: JNCI)
Source: JNCI - April 1, 2016 Category: Cancer & Oncology Authors: Jenks, S. Tags: News Source Type: research
Active Surveillance Gets Personal
(Source: JNCI)
Source: JNCI - April 1, 2016 Category: Cancer & Oncology Authors: Schmidt, C. Tags: News Source Type: research
Adhesion Molecules, Stem Cells, and the Microenvironment in Acute Myeloid Leukemia
(Source: JNCI)
Source: JNCI - April 1, 2016 Category: Cancer & Oncology Authors: Brower, V. Tags: News Source Type: research
Erratum
(Source: JNCI)
Source: JNCI - March 30, 2016 Category: Cancer & Oncology Tags: Erratum Source Type: research
Table_of_Contents
(Source: JNCI)
Source: JNCI - March 9, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: JNCI)
Source: JNCI - March 9, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Cover
(Source: JNCI)
Source: JNCI - March 9, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Erratum
(Source: JNCI)
Source: JNCI - March 8, 2016 Category: Cancer & Oncology Tags: Erratum Source Type: research
