Response
(Source: JNCI)
Source: JNCI - August 30, 2016 Category: Cancer & Oncology Authors: Pan, W.-C., Yang, H.-I. Tags: Response Source Type: research
RE: Fine Particle Pollution, Alanine Transaminase, and Liver Cancer: A Taiwanese Prospective Cohort Study (REVEAL-HBV)
(Source: JNCI)
Source: JNCI - August 30, 2016 Category: Cancer & Oncology Authors: Zhou, Y.-H. Tags: Correspondence Source Type: research
Risk of Advanced Neoplasia Using the National Cancer Institutes Colorectal Cancer Risk Assessment Tool
Conclusions: The NCI’s Risk Assessment Tool, which estimates future CRC risk, may be used to estimate current risk for advanced neoplasia, making it potentially useful for tailoring and improving CRC screening efficiency among average-risk persons. (Source: JNCI)
Source: JNCI - August 30, 2016 Category: Cancer & Oncology Authors: Imperiale, T. F., Yu, M., Monahan, P. O., Stump, T. E., Tabbey, R., Glowinski, E., Ransohoff, D. F. Tags: Article Source Type: research
The Efficacy and Safety of First-line Chemotherapy in Advanced Esophagogastric Cancer: A Network Meta-analysis
Conclusions: Based on efficacy and toxicity, F-doublets FOx, FI, and FT are preferred as first-line treatment for AEGC compared with C-doublets, A-triplets, and TCF. FOxT is the most promising triplet. (Source: JNCI)
Source: JNCI - August 29, 2016 Category: Cancer & Oncology Authors: ter Veer, E., Haj Mohammad, N., van Valkenhoef, G., Ngai, L. L., Mali, R. M. A., Anderegg, M. C., van Oijen, M. G. H., van Laarhoven, H. W. M. Tags: Meta-Analysis Source Type: research
IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma
Conclusions: We discovered new druggable targets expressed by chemoresistant ES cells, xenografts, and relapsed human tumors. Joint suppression of these newfound targets, in concert with IGF-1R or mTOR blockade, should improve clinical outcomes. (Source: JNCI)
Source: JNCI - August 29, 2016 Category: Cancer & Oncology Authors: Lamhamedi-Cherradi, S.-E., Menegaz, B. A., Ramamoorthy, V., Vishwamitra, D., Wang, Y., Maywald, R. L., Buford, A. S., Fokt, I., Skora, S., Wang, J., Naing, A., Lazar, A. J., Rohren, E. M., Daw, N. C., Subbiah, V., Benjamin, R. S., Ratan, R., Priebe, W., M Tags: Article Source Type: research
Inactivation of Cancer Mutations Utilizing CRISPR/Cas9
Although whole-genome sequencing has uncovered a large number of mutations that drive tumorigenesis, functional ratification for most mutations remains sparse. Here, we present an approach to test functional relevance of tumor mutations employing CRISPR/Cas9. Combining comprehensive sgRNA design and an efficient reporter assay to nominate efficient and selective sgRNAs, we establish a pipeline to dissect roles of cancer mutations with potential applicability to personalized medicine and future therapeutic use. (Source: JNCI)
Source: JNCI - August 29, 2016 Category: Cancer & Oncology Authors: Gebler, C., Lohoff, T., Paszkowski-Rogacz, M., Mircetic, J., Chakraborty, D., Camgoz, A., Hamann, M. V., Theis, M., Thiede, C., Buchholz, F. Tags: Brief Communication Source Type: research
Long-term Consequences of Finasteride vs Placebo in the Prostate Cancer Prevention Trial
Conclusions: Finasteride use is associated with reduced need for procedures for relief of BPH-related events and a modest increase in depression. Overall, there is little need to worry about long-term noncancer consequences of finasteride use in those who use it for treatment of symptomatic BPH, hair growth, or prevention of cancer. (Source: JNCI)
Source: JNCI - August 25, 2016 Category: Cancer & Oncology Authors: Unger, J. M., Till, C., Thompson, I. M., Tangen, C. M., Goodman, P. J., Wright, J. D., Barlow, W. E., Ramsey, S. D., Minasian, L. M., Hershman, D. L. Tags: Article Source Type: research
Pleiotropic Analysis of Lung Cancer and Blood Triglycerides
Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lung cancer case patients and 16 838 control subjects) and cardiovascular disease risk factors (blood lipids from 188 577 subjects, type 2 diabetes from 148 821 subjects, body mass index from 123 865 subjects, and smoking phenotypes from 74 053 subjects). We found that 6p22.1 (rs6904596, ZNF184) was associated with both lung cancer...
Source: JNCI - August 25, 2016 Category: Cancer & Oncology Authors: Zuber, V., Marconett, C. N., Shi, J., Hua, X., Wheeler, W., Yang, C., Song, L., Dale, A. M., Laplana, M., Risch, A., Witoelar, A., Thompson, W. K., Schork, A. J., Bettella, F., Wang, Y., Djurovic, S., Zhou, B., Borok, Z., van der Heijden, H. F. M., de Gra Tags: Brief Communication Source Type: research
Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes
Conclusions: Overall, selenium did not prevent colorectal adenomas and showed only modest benefit in patients with baseline advanced adenomas. With limited benefit and similar increases in T2D to other trials, selenium is not recommended for preventing colorectal adenomas in selenium-replete individuals. (Source: JNCI)
Source: JNCI - August 15, 2016 Category: Cancer & Oncology Authors: Thompson, P. A., Ashbeck, E. L., Roe, D. J., Fales, L., Buckmeier, J., Wang, F., Bhattacharyya, A., Hsu, C.-H., Chow, H. H. S., Ahnen, D. J., Boland, C. R., Heigh, R. I., Fay, D. E., Hamilton, S. R., Jacobs, E. T., Martinez, M. E., Alberts, D. S., Lance, Tags: Article Source Type: research
Celecoxib for the Prevention of Colorectal Adenomas: Results of a Suspended Randomized Controlled Trial
Conclusions: Limited-duration celecoxib prevents adenoma recurrence in patients with prior high-risk adenomas, in whom strategies to minimize cardiovascular toxicity might be feasible. (Source: JNCI)
Source: JNCI - August 15, 2016 Category: Cancer & Oncology Authors: Thompson, P. A., Ashbeck, E. L., Roe, D. J., Fales, L., Buckmeier, J., Wang, F., Bhattacharyya, A., Hsu, C.-H., Chow, S. H. H., Ahnen, D. J., Boland, C. R., Heigh, R. I., Fay, D. E., Hamilton, S. R., Jacobs, E. T., Martinez, E. M., Alberts, D. S., Lance, Tags: Article Source Type: research
Mesothelioma Death Rate by State, (1999-2010)
(Source: JNCI)
Source: JNCI - August 9, 2016 Category: Cancer & Oncology Tags: Stat Bite Source Type: research
Tackling Mesothelioma With Immunotherapies
(Source: JNCI)
Source: JNCI - August 9, 2016 Category: Cancer & Oncology Authors: Brower, V. Tags: NEWS Source Type: research
Mammaprint Reveals Who Can Skip Chemotherapy for Breast Cancer
(Source: JNCI)
Source: JNCI - August 9, 2016 Category: Cancer & Oncology Authors: Schmidt, C. Tags: NEWS Source Type: research
PDQ (Physician Data Query)
(Source: JNCI)
Source: JNCI - August 9, 2016 Category: Cancer & Oncology Tags: NEWS Source Type: research
Physical Activity Associated With Fewer Cancers
(Source: JNCI)
Source: JNCI - August 9, 2016 Category: Cancer & Oncology Authors: Jenks, S. Tags: NEWS Source Type: research
