Satellite glial cells represent a population of developmentally arrested Schwann cells
Glia, EarlyView. (Source: Glia)
Source: Glia - March 9, 2018 Category: Neurology Source Type: research
Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury
Glia, EarlyView. (Source: Glia)
Source: Glia - March 9, 2018 Category: Neurology Source Type: research
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Glia, Ahead of Print. (Source: Glia)
Source: Glia - March 9, 2018 Category: Neurology Source Type: research
Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury
Abstract
Sensory neurons in the PNS demonstrate substantial capacity for regeneration following injury. Recent studies have identified changes in the transcriptome of sensory neurons, which are instrumental for axon regeneration. The role of Schwann cells (SCs) in mediating these changes remains undefined. We tested the hypothesis that SCs regulate expression of genes in sensory neurons before and after PNS injury by comparing mice in which LDL Receptor‐related Protein‐1 (LRP1) is deleted in SCs (scLRP1−/− mice) with wild‐type (scLRP1+/+) littermates. LRP1 is an endocytic and cell‐signaling receptor that is nec...
Source: Glia - March 9, 2018 Category: Neurology Authors: Gunnar Poplawski, Tetsuhiro Ishikawa, Coralie Brifault, Corinne Lee ‐Kubli, Robert Regestam, Kenneth W. Henry, Yasuhiro Shiga, HyoJun Kwon, Seiji Ohtori, Steven L. Gonias, Wendy M. Campana Tags: RESEARCH ARTICLE Source Type: research
Satellite glial cells represent a population of developmentally arrested Schwann cells
In this study, we examine the development of SGCs. We show that rat SGCs develop postnatally and these cells express a number of markers associated with Schwann cell precursors, in particular cadherin‐19 (CDH19) even in adult DRGs. We developed a method for the purification of SGCs and showed that they are transcriptionally and morphologically very similar to adult rat Schwann cells (SCs). Finally, we demonstrate that purified SGCs are capable of myelinating embryonic axons when cocultured with those axons. Based on these observations we hypothesize that SGCs represent a population of cells in the SC lineage, whose furth...
Source: Glia - March 9, 2018 Category: Neurology Authors: Dale George, Paige Ahrens, Stephen Lambert Tags: RESEARCH ARTICLE Source Type: research
Dopamine D1 receptor ‐mediated upregulation of BKCa currents modifies Müller cell gliosis in a rat chronic ocular hypertension model
Abstract
Müller cell gliosis is a common response in many retinal pathological conditions. We previously demonstrated that downregulation of Kir channels contributes to Müller cell gliosis in a rat chronic ocular hypertension (COH) model. Here, the possible involvement of outward K+ currents in Müller cell gliosis was investigated. Outward K+ current densities in Müller cells isolated from COH rats, as compared with those in normal rats, showed a significant increase, which was mainly contributed by large‐conductance Ca2+‐activated K+ (BKCa) channels. The involvement of BKCa channels in Müller cell gliosis is sugg...
Source: Glia - March 6, 2018 Category: Neurology Authors: Hang ‐Jing Wu, Xue‐Yan Li, Wen‐Jing Qian, Qian Li, Shu‐Yue Wang, Min Ji, Yuan‐Yuan Ma, Feng Gao, Xing‐Huai Sun, Xin Wang, Yanying Miao, Xiong‐Li Yang, Zhongfeng Wang Tags: RESEARCH ARTICLE Source Type: research
Dopamine D1 receptor ‐mediated upregulation of BKCa currents modifies Müller cell gliosis in a rat chronic ocular hypertension model
Glia, EarlyView. (Source: Glia)
Source: Glia - March 6, 2018 Category: Neurology Source Type: research
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Glia, Ahead of Print. (Source: Glia)
Source: Glia - March 6, 2018 Category: Neurology Source Type: research
Aging ‐associated changes in hippocampal glycogen metabolism in mice. Evidence for and against astrocyte‐to‐neuron lactate shuttle
Abstract
Lactate derived from astrocytic glycogen has been shown to support memory formation in hippocampi of young animals, inhibiting it in old animals. Here we show, using quantitative mass spectrometry‐based proteomics, immunofluorescence, and qPCR that aging is associated with an increase of glycogen metabolism enzymes concentration and shift in their localization from astrocytes to neurons. These changes are accompanied with reorganization of hippocampal energy metabolism which is manifested by elevated capacity of aging neurons to oxidize glucose in glycolysis and mitochondria, and decreased ability for fatty acid...
Source: Glia - March 1, 2018 Category: Neurology Authors: Dominika Drulis ‐Fajdasz, Agnieszka Gizak, Tomasz Wójtowicz, Jacek R. Wiśniewski, Dariusz Rakus Tags: RESEARCH ARTICLE Source Type: research
Aging ‐associated changes in hippocampal glycogen metabolism in mice. Evidence for and against astrocyte‐to‐neuron lactate shuttle
Glia, EarlyView. (Source: Glia)
Source: Glia - March 1, 2018 Category: Neurology Source Type: research
Plaque ‐dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model
Glia, EarlyView. (Source: Glia)
Source: Glia - March 1, 2018 Category: Neurology Source Type: research
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Glia, Ahead of Print. (Source: Glia)
Source: Glia - March 1, 2018 Category: Neurology Source Type: research
