Issue Information ‐ Table of Contents
(Source: Glia)
Source: Glia - October 16, 2017 Category: Neurology Tags: ISSUE INFORMATION ‐ TABLE OF CONTENTS Source Type: research
Ulk4 deficiency leads to hypomyelination in mice
Abstract
Brain nerve fibers are insulated by myelin which is produced by oligodendrocytes. Defects in myelination are increasingly recognized as a common pathology underlying neuropsychiatric and neurodevelopmental disorders, which are associated with deletions of the Unc‐51‐like kinase 4 (ULK4) gene. Key transcription factors have been identified for oligodendrogenesis, but little is known about their associated regulators. Here we report that Ulk4 acts as a key regulator of myelination. Myelination is reduced by half in the Ulk4tm1a/tm1a hypomorph brain, whereas expression of axonal marker genes Tubb3, Nefh, Nefl and...
Source: Glia - October 16, 2017 Category: Neurology Authors: Min Liu, Ping Xu, Zhenlong Guan, Xiaohong Qian, Peter Dockery, Una Fitzgerald, Timothy O'Brien, Sanbing Shen Tags: RESEARCH ARTICLE Source Type: research
Cellular and molecular characterization of IDH1 ‐mutated diffuse low grade gliomas reveals tumor heterogeneity and absence of EGFR/PDGFRα activation
Abstract
Diffuse low grade gliomas (DLGG, grade II gliomas) are slowly‐growing brain tumors that often progress into high grade gliomas. Most tumors have a missense mutation for IDH1 combined with 1p19q codeletion in oligodendrogliomas or ATRX/TP53 mutations in astrocytomas. The phenotype of tumoral cells, their environment and the pathways activated in these tumors are still ill‐defined and are mainly based on genomics and transcriptomics analysis. Here we used freshly‐resected tumors to accurately characterize the tumoral cell population and their environment. In oligodendrogliomas, cells express the transcription ...
Source: Glia - October 13, 2017 Category: Neurology Authors: S. Azar, N Leventoux, C Ripoll, V. Rigau, C. Goz é, F. Lorcy, L. Bauchet, H. Duffau, P. O. Guichet, B. Rothhut, J. P. Hugnot Tags: RESEARCH ARTICLE Source Type: research
Immunization with α‐synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model
Abstract
Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded α‐synuclein (αSyn) protein, is known to contribute to the pathophysiology of Parkinson's disease (PD). In this work, based on the immunomodulatory activities displayed by particular heat‐shock proteins (HSPs), we tested a novel vaccination strategy that used a combination of αSyn and Grp94 (HSPC4 or Gp96) chaperone and a murine PD model. We used two different procedures, first, the adoptive transfer of splenocytes from αSyn/Grp94‐immunized mice to recipient animals, and second, direct immun...
Source: Glia - October 11, 2017 Category: Neurology Authors: Javier Villadiego, Adahir Labrador ‐Garrido, Jaime M. Franco, Magdalena Leal‐Lasarte, Erwin J. De Genst, Christopher M. Dobson, David Pozo, Juan J. Toledo‐Aral, Cintia Roodveldt Tags: RESEARCH ARTICLE Source Type: research
Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes
Abstract
In Schwann cells of the vertebrate peripheral nervous system, induction of myelination and myelin maintenance both depend on the HMG‐domain‐containing transcription factor Sox10. In oligodendrocytes of the central nervous system, Sox10 is also essential for the induction of myelination. Its role in late phases of myelination and myelin maintenance has not been studied so far. Here, we show that these processes are largely unaffected in mice that lack Sox10 in mature oligodendrocytes. As Sox10 is co‐expressed with the related Sox8, we also analyzed oligodendrocytes and myelination in Sox8‐deficient mice. Ag...
Source: Glia - October 11, 2017 Category: Neurology Authors: Tanja Turnescu, Juliane Arter, Simone Reiprich, Ernst R. Tamm, Ari Waisman, Michael Wegner Tags: RESEARCH ARTICLE Source Type: research
