Activating transcription factor 6 α deficiency exacerbates oligodendrocyte death and myelin damage in immune‐mediated demyelinating diseases
Glia, EarlyView. (Source: Glia)
Source: Glia - February 13, 2018 Category: Neurology Source Type: research
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Glia, Ahead of Print. (Source: Glia)
Source: Glia - February 13, 2018 Category: Neurology Source Type: research
Differential local tissue permissiveness influences the final fate of GPR17 ‐expressing oligodendrocyte precursors in two distinct models of demyelination
Abstract
Promoting remyelination is recognized as a novel strategy to foster repair in neurodegenerative demyelinating diseases, such as multiple sclerosis. In this respect, the receptor GPR17, recently emerged as a new target for remyelination, is expressed by early oligodendrocyte precursors (OPCs) and after a certain differentiation stage it has to be downregulated to allow progression to mature myelinating oligodendrocytes. Here, we took advantage of the first inducible GPR17 reporter mouse line (GPR17‐iCreERT2xCAG‐eGFP mice) allowing to follow the final fate of GPR17+ cells by tamoxifen‐induced GFP‐labeling to...
Source: Glia - February 9, 2018 Category: Neurology Authors: Giusy T. Coppolino, Davide Marangon, Camilla Negri, Gianluca Menichetti, Marta Fumagalli, Paolo Gelosa, Leda Dimou, Roberto Furlan, Davide Lecca, Maria P. Abbracchio Tags: RESEARCH ARTICLE Source Type: research
Astrocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis
Abstract
To elucidate mechanisms contributing to cortical pathology in multiple sclerosis (MS), we investigated neurovascular aberrations, in particular the association of astrocytes with cortical neurons and blood vessels, in mice induced with experimental autoimmune encephalomyelitis (EAE). Blood–brain barrier (BBB) dysfunction was evident by leakage of the tracer sodium fluorescein, along with reduced expression of claudin‐5 by endothelial cells and desmin by pericytes. Immunohistological and ultrastructural analyses revealed detachment of the astroglial cell bodies from the blood vessels and loss of their connectio...
Source: Glia - February 9, 2018 Category: Neurology Authors: Raya Eilam, Menahem Segal, Rafael Malach, Michael Sela, Ruth Arnon, Rina Aharoni Tags: RESEARCH ARTICLE Source Type: research
Vitamin C promotes oligodendrocytes generation and remyelination
Glia, EarlyView. (Source: Glia)
Source: Glia - February 9, 2018 Category: Neurology Source Type: research
Differential local tissue permissiveness influences the final fate of GPR17 ‐expressing oligodendrocyte precursors in two distinct models of demyelination
Glia,Volume 66, Issue 5, Page 1118-1130, May 2018. (Source: Glia)
Source: Glia - February 9, 2018 Category: Neurology Source Type: research
Astrocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis
Glia,Volume 66, Issue 5, Page 1098-1117, May 2018. (Source: Glia)
Source: Glia - February 9, 2018 Category: Neurology Source Type: research
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Glia, Ahead of Print. (Source: Glia)
Source: Glia - February 9, 2018 Category: Neurology Source Type: research
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Glia,Volume 66, Issue 5, Page 1118-1130, May 2018. (Source: Glia)
Source: Glia - February 9, 2018 Category: Neurology Source Type: research
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Glia,Volume 66, Issue 5, Page 1098-1117, May 2018. (Source: Glia)
Source: Glia - February 9, 2018 Category: Neurology Source Type: research
Vitamin C promotes oligodendrocytes generation and remyelination
Abstract
Oligodendrocyte‐formed myelin sheaths play important roles in the neuronal functions in the central nervous system. In demyelinating diseases, such as Multiple Sclerosis, the myelin sheaths are damaged and the remyelinating process is somehow hindered. Restoration of the myelin sheaths requires the differentiation of the oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs). To discover small molecule compounds that might promote the OPC to OL differentiation, a high‐throughput screening system is established and L‐ascorbyl‐2‐phosphate (As‐2P), a stable form of Vitamin C (Vc), is fo...
Source: Glia - February 9, 2018 Category: Neurology Authors: Yu ‐e Guo, Na Suo, Xue Cui, Qianting Yuan, Xin Xie Tags: RESEARCH ARTICLE Source Type: research
Tanycytes and hypothalamic control of energy metabolism
Abstract
Studies from a number of areas of neuroendocrinology indicate that hypothalamic tanycytes play a key role in control of energy metabolism. First, profound annual changes in gene expression have been identified in these unusual glial cells in seasonal mammals, for example in genes relating to the transport and metabolism of thyroid hormone into the hypothalamus. The consequent changes in local thyroid hormone availability in the hypothalamus have been shown experimentally to regulate annual cycles in energy intake, storage and expenditure in seasonal species. This is reflected in overt seasonal changes in appetite,...
Source: Glia - February 7, 2018 Category: Neurology Authors: Francis J. P. Ebling, Jo E. Lewis Tags: INVITED Source Type: research
Wnt signaling regulates proliferation and differentiation of radial glia in regenerative processes after stab injury in the optic tectum of adult zebrafish
Glia, EarlyView. (Source: Glia)
Source: Glia - February 7, 2018 Category: Neurology Source Type: research
Tanycytes and hypothalamic control of energy metabolism
Glia, EarlyView. (Source: Glia)
Source: Glia - February 7, 2018 Category: Neurology Source Type: research
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Glia, Ahead of Print. (Source: Glia)
Source: Glia - February 7, 2018 Category: Neurology Source Type: research
