Wnt signaling regulates proliferation and differentiation of radial glia in regenerative processes after stab injury in the optic tectum of adult zebrafish
Abstract
Zebrafish have superior abilities to generate new neurons in the adult brain and to regenerate brain tissue after brain injury compared with mammals. There exist two types of neural stem cells (NSCs): neuroepithelial‐like stem cells (NE) and radial glia (RG) in the optic tectum. We established an optic tectum stab injury model to analyze the function of NSCs in the regenerative condition and confirmed that the injury induced the proliferation of RG, but not NE and that the proliferated RG differentiated into new neurons after the injury. We then analyzed the involvement of Wnt signaling after the injury, using a...
Source: Glia - February 7, 2018 Category: Neurology Authors: Yuki Shimizu, Yuto Ueda, Toshio Ohshima Tags: RESEARCH ARTICLE Source Type: research
The microglial reaction signature revealed by RNAseq from individual mice
Abstract
Microglial cells have a double life as the immune cells of the brain in times of stress but have also specific physiological functions in homeostatic conditions. In pathological contexts, microglia undergo a phenotypic switch called “reaction” that promotes the initiation and the propagation of neuro‐inflammation. Reaction is complex, molecularly heterogeneous and still poorly characterized, leading to the concept that microglial reactivity might be too diverse to be molecularly defined. However, it remains unknown whether reactive microglia from different pathological contexts share a common molecular signa...
Source: Glia - February 5, 2018 Category: Neurology Authors: H élène Hirbec, Camille Marmai, Isabelle Duroux‐Richard, Christine Roubert, Arnaud Esclangon, Séverine Croze, Joël Lachuer, Ronan Peyroutou, François Rassendren Tags: RESEARCH ARTICLE Source Type: research
The microglial reaction signature revealed by RNAseq from individual mice
Glia,Volume 66, Issue 5, Page 971-986, May 2018. (Source: Glia)
Source: Glia - February 5, 2018 Category: Neurology Source Type: research
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Glia,Volume 66, Issue 5, Page 971-986, May 2018. (Source: Glia)
Source: Glia - February 5, 2018 Category: Neurology Source Type: research
A single ‐cell analysis reveals multiple roles of oligodendroglial lineage cells during post‐ischemic regeneration
Abstract
NG2 cells represent precursors of oligodendrocytes under physiological conditions; however, following cerebral ischemia they play an important role in glial scar formation. Here, we compared the expression profiles of oligodendroglial lineage cells, after focal cerebral ischemia (FCI) and in Alzheimer's‐like pathology using transgenic mice, which enables genetic fate‐mapping of Cspg4‐positive NG2 cells and their progeny, based on the expression of red fluorescent protein tdTomato. tdTomato‐positive cells possessed the expression profile of NG2 cells and oligodendrocytes; however, based on the expression of...
Source: Glia - February 2, 2018 Category: Neurology Authors: Valny Martin, Honsa Pavel, Waloschkova Eliska, Matuskova Hana, Kriska Jan, Kirdajova Denisa, Androvic Peter, Valihrach Lukas, Kubista Mikael, Anderova Miroslava Tags: RESEARCH ARTICLE Source Type: research
p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression
Glia,Volume 66, Issue 5, Page 999-1015, May 2018. (Source: Glia)
Source: Glia - February 2, 2018 Category: Neurology Source Type: research
A single ‐cell analysis reveals multiple roles of oligodendroglial lineage cells during post‐ischemic regeneration
Glia,Volume 66, Issue 5, Page 1068-1081, May 2018. (Source: Glia)
Source: Glia - February 2, 2018 Category: Neurology Source Type: research
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Glia,Volume 66, Issue 5, Page 999-1015, May 2018. (Source: Glia)
Source: Glia - February 2, 2018 Category: Neurology Source Type: research
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Glia,Volume 66, Issue 5, Page 1068-1081, May 2018. (Source: Glia)
Source: Glia - February 2, 2018 Category: Neurology Source Type: research
p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression
Abstract
Malignant glioma is one of the deadliest types of cancer. Understanding how the cell of origin progressively evolves toward malignancy in greater detail could provide mechanistic insights and lead to novel concepts for tumor prevention and therapy. Previously we have identified oligodendrocyte precursor cell (OPC) as the cell of origin for glioma following the concurrent deletion of p53 and NF1 using a mouse genetic mosaic system that can reveal mutant cells prior to malignancy. In the current study, we set out to deconstruct the gliomagenic process in two aspects. First, we determined how the individual loss of p...
Source: Glia - February 2, 2018 Category: Neurology Authors: Phillippe P. Gonzalez, Jungeun Kim, Rui Pedro Galvao, Nichola Cruickshanks, Roger Abounader, Hui Zong Tags: RESEARCH ARTICLE Source Type: research
miR147b: A novel key regulator of interleukin 1 beta ‐mediated inflammation in human astrocytes
Abstract
Astrocytes are important mediators of inflammatory processes in the brain and seem to play an important role in several neurological disorders, including epilepsy. Recent studies show that astrocytes produce several microRNAs, which may function as crucial regulators of inflammatory pathways and could be used as therapeutic target. We aim to study which miRNAs are produced by astrocytes during IL‐1β mediated inflammatory conditions in vitro, as well as their functional role and to validate these findings in human epileptogenic brain tissue. Sequencing was used to assess miRNA and mRNA expression in IL‐1β‐s...
Source: Glia - January 31, 2018 Category: Neurology Authors: Jackelien van Scheppingen, James D. Mills, Till S. Zimmer, Diede W.M. Broekaart, Valentina Iori, Anika Bongaarts, Jasper J. Anink, Anand M. Iyer, Anatoly Korotkov, Floor E. Jansen, Wim van Hecke, Wim G. Spliet, Peter C. van Rijen, Johannes C. Baayen, Anna Tags: RESEARCH ARTICLE Source Type: research
miR147b: A novel key regulator of interleukin 1 beta ‐mediated inflammation in human astrocytes
Glia,Volume 66, Issue 5, Page 1082-1097, May 2018. (Source: Glia)
Source: Glia - January 31, 2018 Category: Neurology Source Type: research
Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model
Glia,Volume 66, Issue 5, Page 1053-1067, May 2018. (Source: Glia)
Source: Glia - January 31, 2018 Category: Neurology Source Type: research
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Glia,Volume 66, Issue 5, Page 1082-1097, May 2018. (Source: Glia)
Source: Glia - January 31, 2018 Category: Neurology Source Type: research
