Clinical Cases in Mineral and Bone Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Clodronate: new directions of use.
In conclusion, clodronate prevents fractures, decrease osteo-articular pain, is easy to handle, tolerable and had a great cost/benefit relationship. PMID: 26604933 [PubMed - as supplied by publisher] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Generic brands in the prevention of fragility fractures.
Authors: Michieli R, Callegaro C Abstract Generic drugs are safe and effective, but their prescription in Italy is among the lowest in Europe (30% to 60-70% in other Countries). According to a recently published retrospective study, generics are not statistically different from their corresponding brand counterpart in the therapy of osteoporosis, a bone defects characterized by a decrease in bone mineral density, which can lead to an increased frailty and risk of fracture. Unfortunately there are a lot of problems in compliance with these drugs: it is only about 7.19% in the first year, despite their consu...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

The natural approach to osteoporosis.
Authors: Bartolozzi E Abstract Osteoporosis is normally the result of a wrong life-style (diet, physical inactivity, smoke, dental hygiene, intestinal dysbiosis,…) and environmental toxicity which stimulate the chronic expression of inflammatory genes and alter the immuno-endocrine balance. A natural approch should face all the factors involved, leading the patients to become aware of their own responsability, and helping them with natural therapies, healthy food and life-style which support their body in the process of self-healing. PMID: 26604935 [PubMed - as supplied by publisher] (Source: Cli...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Prevention and treatment of bone fragility in cancer patient.
Authors: Ottanelli S Abstract It is well known that fractures increase the risk of morbidity and mortality. The various mechanisms responsible for bone loss in cancer patients may have a different impact depending on the characteristics of the clinical case and correlates with the therapies used, or caused by the therapies used against cancer. Some hormonal treatments cause hypogonadism, event which contributes to the progressive loss of bone mass. This is detectable in patients with breast cancer receiving determines that estrogen-deprivation and in men with prostate cancer with therapies that determine a...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Drugs for type 2 diabetes: role in the regulation of bone metabolism.
Authors: Mannucci E, Dicembrini I Abstract Until a few years ago, the possibility that glucose-lowering drugs affect glucose metabolism and fracture risk was not even considered. The increased incidence of fractures with thiazolidinediones in women was a causal finding. This phenomenon, which has been demonstrated by large-scale clinical trials, is associated with a reduction in bone density. Thiazolidinediones stimulate adipocyte differentiation, and inhibit osteoblast differentiation, from bone marrow stromal cells; other mechanisms could also be involved in the thiazolidinedione-induced reduction of bon...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers?
Authors: Sartiani L, Spinelli V, Laurino A, Blescia S, Raimondi L, Cerbai E, Mugelli L Abstract Sarcopenia represents a major health problem highly prevalent in elderly and age-related chronic diseases. Current pharmacological strategies available to prevent and reverse sarcopenia are largely unsatisfactory thus raising the need to identify novel targets for pharmacological intervention and possibly more effective and safe drugs. This review highlights the current knowledge of the potential benefits of renin-angiotensin system blockade in sarcopenia and discuss the main mechanisms underlying the effects. ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Vascular calcification and fracture risk.
Authors: Szulc P Abstract Osteoporosis and cardiovascular diseases are public health problems. Fragility fractures are associated with high risk of cardiovascular event and patients with cardiovascular diseases have higher risk of fracture. Severe abdominal aortic calcification (AAC) is associated with higher cardiovascular mortality and morbidity. Severe AAC is associated with higher risk of fracture. In cross-sectional studies severe AAC was associated with greater prevalence, higher number and greater severity of vertebral fractures after adjustment for confounders including bone mineral density (BMD). ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

New perspectives in echographic diagnosis of osteoporosis on hip and spine.
This article will provide a brief review of the available systems for osteoporosis diagnosis in clinical routine contexts, followed by a synthesis of the most promising research results on the latest ultrasound developments for early osteoporosis diagnosis and fracture prevention. PMID: 26604940 [PubMed - as supplied by publisher] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Rare causes of osteoporosis.
Authors: Marcucci G, Brandi ML Abstract Osteoporosis is a metabolic bone disease characterized by loss of bone mass and strength, resulting in increased risk of fractures. It is classically divided into primary (post-menopausal or senile), secondary and idiopathic forms. There are many rare diseases, that cause directly or indirectly osteoporosis. The identification and classification of most of these rare causes of osteoporosis is crucial for the specialists in endocrinology and not, in order to prevent this bone complication and to provide for an early therapy. Several pathogenic mechanisms are involved,...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Clinical manifestations and management of Gaucher disease.
Authors: Linari S, Castaman G Abstract Gaucher disease is a rare multi-systemic metabolic disorder caused by the inherited deficiency of the lysosomal enzyme β-glucocerebrosidase, which leads to the accumulation of its normal substrate, glucocerebroside, in tissue macrophages with damage to haematological, visceral and bone systems. Anaemia, thrombocytopenia, enlargement of liver and/or spleen, skeletal abnormalities (osteopenia, lytic lesions, pathological fractures, chronic bone pain, bone crisis, bone infarcts, osteonecrosis and skeletal deformities) are typical manifestations of the most prevalent for...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Gaucher disease: the role of the specialist on metabolic bone diseases.
Authors: Masi L, Brandi ML Abstract According to European legislation, a disease can be considered rare or "orphan" when it affects less than 1 subject of 2000 (1). Often these diseases affecting the pediatric age, are complex diseases and chronically debilitating and for this motive need the intervention of multidisciplinary skills specific. Among the rare disease as affecting the skeleton more than 400 are characterized by dysplastic changes of the skeleton (2). Alongside the disorders affecting the skeleton primitively, many systemic diseases can have a bone involvement. Among these, the Gaucher disease...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Clinical management of hypophosphatasia.
Authors: Bishop N Abstract HPP is a rare disease that manifests in different ways across the life course. Accurate diagnosis depends upon the use of appropriate age-related normative data. A new therapy is undergoing clinical trials; the preliminary published data is encouraging, but the scope of clinical application remains to be determined. PMID: 26604944 [PubMed - as supplied by publisher] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Periodontitis and bone metabolism.
Authors: Barbato L, Francioni E, Bianchi M, Mascitelli E, Marco LB, Tonelli DP Abstract Periodontitis is a plaque induced disease characterized by tissue destruction. The extent of the alveolar bone loss depends on the host response stimulated by bacterial infection. Recently researchers have focused on the role of the immune system, of RANK/RANKL/OPG pathway and of cytokines network. Another recent field of interest is osteoimmunology that try to explain the relationship between immune and bone cells in activating bone resorption. Advances in the understanding of the pathogenic mechanisms allowed a better...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Detecting low bone mineral density from dental radiographs: a mini-review.
Authors: Graham J Abstract Over a number of years researchers have reported associations between osteoporosis or low bone mineral density and signs that can be detected on dental radiographs, particularly in the width of the inferior mandibular cortex and the texture of the trabecular bone. As patients visit the dentist more regularly than they visit their doctor, there is the possibility that such signs could be used as a means of identifying individuals at risk of developing osteoporosis or suffering from consequent fracture. This paper reviews the historical background behind this research and the curre...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Bone graft and mesenchimal stem cells: clinical observations and histological analysis.
Authors: Bertolai R, Catelani C, Aversa A, Rossi A, Giannini D, Bani D Abstract Autologous bone, for its osteoconductive, osteoinductive and osteogenetic properties, has been considered to be the gold standard for maxillary sinus augmentation procedures. Autograft procedures bring also some disadvantages: sometimes the limited amount of available intraoral bone makes necessary to obtain bone from an extraoral site, and this carries an associated morbidity. To overcome this problem we started using homologous freeze-dried bone in maxillary sinus augmentation procedures. This bone is industrially processed w...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research