Algodystrophy: recent insight into the pathogenic framework.
Authors: Varenna M, Zucchi F Abstract Algodystrophy, nowadays called CRPS I, is a painful syndrome characterized by sensory and vasomotor disturbance, edema and functional impairment. Significant progress in knowledge about the pathogenic mechanisms of the disease have been recently achieved, but they are not yet fully understood and some clinical aspects are still lacking of a whole pathogenetic comprehension. The local release of pro-inflammatory neuropeptides and some cytokines may be the event that triggers and maintains the disease, causing hyperalgesia and allodynia. In the following phases, the impa...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Effectiveness and utility of hyaluronic acid in osteoarthritis.
Authors: Migliore A, Procopio S Abstract Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Viscosupplementation with intra-articular hyaluronic acid is a treatment option in knee OA that is included in the professional guidelines for treatment of this joint disease, but potentially should apply to all synovial joints in order to reduce pain and improve joint lubrication. Exogenous HA can enhance chondrocyte HA synthesis, prevent the degradation of cartilage and promote its regeneration. Moreover it can reduce the production of proinflam...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

The T.A.R.Ge.T. project: a regional program to reduce hip fracture in elderly patients. Main results of retrospective phase.
Authors: Parri S, Cianferotti L, Marcucci G, Gronchi G, Rizzuti C, Colli E, Manetti B, Naldoni W, Brandi ML Abstract The Tuscany Region was the first Italian Region to initiate a program for the prevention of hip fractures in over 65 year old. The T.A.R.Ge.T. project "Appropriate treatment of geriatric re-fractures in Tuscany" (Trattamento Appropriato delle Rifratture Geriatriche in Toscana), which is still on-going, includes a preliminary phase (2009-2010) for baseline analysis and education of the participating centers and a 4-year-prospective phase (2011-2014). The monitoring system is performed horizon...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Bone care nurses and the evolution of the nurse's educational function: the Guardian Angel(®) research project.
Authors: Alvaro R, Pennini A, Zannetti EB, Cittadini N, Feola M, Rao C, D'Agostino F, Vellone E, Tarantino U Abstract Osteoporosis mostly affects females over 50 years old, worldwide. The main osteoporosis complication is fragility fractures that reduce quality of life and cause morbidity and mortality. Most patients who have fragility fractures are treated for the fracture. However, patients' adherence to follow-up treatment plans is poor. Therefore, tailored educational interventions are needed to improve medication adherence and healthy lifestyles. In this context, the role of bone care nurses is import...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Pre-operative diclofenac HPβCD for pain control of needle biopsy in musculoskeletal neoplasm: preliminary results.
We present the clinical results of a non-randomized study of two eterogeneous groups of patients: "Experimental" Group (1): diclofenac HPβCD 50 mg via s.c. one hour before surgical procedure, local anesthesia and ev. diclofenac HPβCD 50 mg via s.c. 12 hours postoperative; "Conventional" Group (2): local anesthesia and ev. postoperative tramadol 100 mg via oral for pain control. In October 2014, at the Department of Orthopedic Oncology and Reconstructive Surgery of Florence, 37 musculoskeletal biopsies for a bone or a soft tissue lesion were performed. Exclusion criteria for this study were: known allergies to lidocaine, ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Osteoid producing primary lesion at morphologic and biologic interface.
Authors: Sarkar RR Abstract Fibroosseous gnathic lesions comprise a wide spectrum of diseases. Many of the entities have overlapping features. A pediatric case is encountered with a complex clinicopathologic profile. Although radiographically the lesion appears benign but on histopathological examination it possesses features of osteoid producing aggressive neoplasm. This paper highlights the unusual histologic features existing within the spectrum of fibroosseous lesions and discusses relevant clinicopathologic correlations. PMID: 26136797 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Stemless humeral component in reverse shoulder prosthesis in patient with Parkinson's disease: a case report.
CONCLUSION: In selected cases of patients with PD, after carefully analysis of bone quality, the use of a stemless component is of benefit in the possible revision cases for periprosthetic fractures and the use of an anterosuperior exposure reduces the percentage of instability. The results obtained about the pain relief are excellent in contrast with functional outcomes that remain poor. PMID: 26136798 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Tendoachillis avulsion in osteomalacia.
Authors: Gupta N, Nigam V Abstract Sixteen-year-old girl presented with generalized body pain with avulsion of tendoachillis on minimal trauma. Surgical repair led to complete recovery. Investigations revealed severe osteomalacia, which improved on supplementation. Surgical difficulty encountered was soft nature of bone, difficult attachment of tendon and delayed rehabilitation. Vitamin D evaluation is essential in young females presenting with generalized body pain and pain at attachments of strong muscles with bones. PMID: 26136799 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

A rare case report of tumoral calcinosis syndrome in an adult with rheumatoid arthritis.
Authors: Patel H, Shaaban H, Benn H Abstract Tumoral calcinosis is a rare benign disease entity that mimics a neoplasm and is manifested by calcium deposition in the soft tissues around the large joints. It can be primary or secondary to renal failure and hyperparathyroidism. This is, to our knowledge, the first reported case of tumoral calcinosis in a Hispanic male with rheumatoid arthritis. PMID: 26136800 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

A case of oncogenic osteomalacia due to occult nasal sinus tumor.
Authors: Ray S, Chakraborty PP, Biswas K, Ghosh S, Mukhopadhyay S, Chowdhury S Abstract This paper shows a case of oncogenic osteomalacia in a 35-year-old man who presented with a 2-year history of generalized pain and progressive weakness of lower limbs, eventually became bed bound. At admission he had severe hip pain resulting from atraumatic femoral neck fractures. Laboratory investigations revealed hypophosphatemia, hyperphosphaturia, normocalcemia, elevated alkaline phosphatase, and normal serum levels of parathormone and 25-hydroxyvitamin D. Serum FGF-23 was elevated. Imaging showed osteoporosis and ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Severe polyarthritis secondary to zolendronic acid: a case report and literature review.
We report the case of an older patient with osteoporosis and osteoarthritis who presented within 12 hours of her first zolendronic acid infusion with evidence of a severe acute polyarthritis affecting her peripheral appendicular skeleton, in joints affected by pre-existing osteoarthritis. Despite the prevalence of osteoarthritis, this is the most severe case of polyarthritis following intravenous zolendronic acid to date and only the second reported case. We remind prescribing physicians treating patients with intravenous bisphosphonates, to bear in mind possible rare serious adverse reactions as well as common benign side...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Unilateral compressive optic neuropathy due to skull hyperostosis secondary to nutritional vitamin A deficiency.
We report a 17-year-old boy who presented with a chronic left unilateral optic neuropathy. Computerized tomography and magnetic resonance imaging demonstrated compression of the left optic nerve due to skull hyperostosis. He was found to be profoundly vitamin A deficient secondary to an unusual diet consisting predominantly of potato chips and crisps. Skull hyperostosis with cranial neuropathies and other neurological abnormalities has been described in growing animals fed vitamin A deficient diets but has not been previously reported in humans. PMID: 26136803 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Voriconazole-related periostitis presenting on magnetic resonance imaging.
This report describes the presentation of voriconazole-related periostitis on magnetic resonance imaging. PMID: 26136804 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Can injection of PMMA-microspheres cause hypercalcemia?
Authors: Lemperle G, Nacul AM, Fortes FB PMID: 26136805 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

From the Editor-in-Chief.
Authors: Brandi ML PMID: 26604932 [PubMed - as supplied by publisher] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research