Clinical Cases in Mineral and Bone Metabolism 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.General Practitioner and FRAX(®) (computer-based algorithm).
Authors: Michieli R, Carraro AM
Abstract
Osteoporotic fractures became the most important cause of disability and an increasing burden to the public health costs in Italy and in many regions of the world. Health professionals play a central role in identifying people at high risk of osteoporosis and osteoporotic fractures. However it is important to have available methods that allow to identify patients showing high risk of fragility fractures, with lower costs and high sensitivity than those currently adopted, e.g. Dual Energy X-ray Absorptiometry (DEXA). The computer-based algorithm (FRAX®) developed by...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Alendronate soluble solution: a higher adherence rate in the treatment of osteoporosis.
CONCLUSIONS: The investigation showed higher adherence to the oral therapy with soluble alendronate, demonstrating that a formulation obtained by this method can contribute to a higher level of persistence with the treatment of a disease such as osteoporosis, which requires a long-term therapeutic plan.
PMID: 25285141 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Vγ9Vδ2 T lymphocytes activation in osteoporotic patients treated with bisphosphonates.
Authors: Sprini D, Di Stefano L, Rini GB, Cianferotti L, Napoli N
Abstract
Treatment with bisphosphonates induces differentiation and activation of Vγ9Vδ2 T lymphocytes obtained from peripheral blood showing also an antitumoral effect in both in vitro and in vivo models. Aim of the present study was to determine in vivo the effect of BPs treatment in patients affected with osteoporosis on Vγ9Vδ2 T lymphocytes. We have studied Vγ9Vδ2 T lymphocytes expansion and differentiation from PBMC obtained from osteoporotic patients treated with one of the following bisphosphonates zoledronate, alendronate, neri...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Osteoporosis and risk of fracture, analysis on a population admitted in rehabilitation post-acute.
Authors: Topini C, Topini D, Cerica G, Nardocci F, Topini G
Abstract
In the context of osteoporosis the presence of a fragility fracture (vertebral or non-vertebral) constitutes a condition of severe osteoporosis; the most common fractures due to this disease are the responsibility of the proximal femur (hip), spine and wrist representing one of the leading causes of disability in the elderly population, as well as one of the greatest contributions to health care costs. By analyzing a population of patients hospitalized at a rehabilitation ward for post-acute outcomes of hip fracture fragility it was able ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Motorised mobility scooters; upper limb fractures in elderly novice users.
We describe three upper limb injuries admitted in one year to our institution resulting from falls from motorised mobility scooters (MMS) where all three users were novices, using their MMS for less than 6 weeks. They sustained injuries in close proximity to their homes, necessitating admission to hospital. None had received any formal training before commencing use of their respective devices. Use of MMS devices increases independence in mobility, enhances quality of life, improves self-esteem, facilitating social participation in everyday life. Use of these devices is not without risks, and no clear safety guidelines or ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Osteoporosis with vertebral fractures associated with pregnancy: two case reports.
Authors: Raffaetà G, Mazzantini M, Menconi A, Bottai V, Falossi F, Celauro I, Guido G
Abstract
Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition characterized by the occurrence of fragility fractures, most commonly vertebral, in late pregnancy or the early postpartum period. The prevalence, etiology and pathogenesis of this osteoporosis are unknown, although there are several hypotheses attempting to explain the etiopathogenesis of pregnancy associated osteoporosis. In this paper we present two cases of young women who developed severe PAO with vertebral fractures: a 42-year-old wo...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Pregnancy-associated osteoporosis with seven vertebral compression fractures, a case treated with strontium ranelate.
Authors: Zarattini G, Buffoli P, Isabelli G, Marchese M
Abstract
This paper shows a case of pregnancy-associated osteoporosis (PAO) with seven vertebral compression fractures treated with strontium ranelate and supplementation of calcium and cholecalciferol. Clinical evaluation, laboratory and radiological results are analyzed in the case-report to demonstrate that strontium ranelate is a good option to restore quickly the value of bone mineral density in the treatment of a case of PAO.
PMID: 25285146 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
A case report of defective endogenous vitamin D: a new clinical entity.
CONCLUSIONS: We hypothesize that this patient had an inadequate number of vitamin D receptors that was corrected by exogenous administration of vitamin D.
PMID: 25285147 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Case report: late subtrochanteric fracture post radiofrequency ablation of osteoid osteoma.
Authors: Bonicoli E, Andreani L, Piolanti N, Zarra V, Lisanti M
Abstract
Osteoid osteoma is a benign tumor especially affecting young males generally treated with radiofrequency ablation. This is a non-invasive and safe procedure, major complications are very rare, most of them consisting in local skin burns. The present case shows a late subtrochanteric fracture in a young boy after CT guided termoablation of osteoid osteoma of proximal femur and short review of the literature.
PMID: 25285148 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
A case of bilateral stress fractures in an old woman: three years of pain.
Authors: Scaglione M, Fabbri L, Dell'Omo D, Gambini F, Di Rollo F, Guido G
Abstract
In elderly patients frequent episodes of joint pain of lower limbs exacerbated by stress and resistant to treatment occur frequently. This paper reports a case of a long lasting bilateral atraumatic knee pain with a final diagnosis of bilateral stress fractures of proximal tibia in osteoporotic postmenopausal woman. The distinctive trait of this case is that the fracture has set in bilaterally and associated with an isthmic L4-L5 spondylolisthesis in a patient afflicted by a decline in mood. This particular clinical picture...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
From the Editor-in-Chief.
Authors: Brandi ML
PMID: 25568645 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Pain pharmacology: focus on opioids.
Authors: Fornasari D
Abstract
The incidence of chronic pain is estimated to be 20-25% worldwide. Although major improvements in pain control have been obtained, more than 50% of the patients reports inadequate relief. It is accepted that chronic pain, if not adequately and rapidly treated, can become a disease in itself, often intractable and maybe irreversible. This is mainly due to neuroplasticity of pain pathways. In the present review I will discuss about pain depicting the rational for the principal pharmacological interventions and finally focusing on opioids, that represent a primary class of drug t...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Pathogenesis and clinical aspects of pain in patients with osteoporosis.
Authors: Mediati RD, Vellucci R, Dodaro L
Abstract
Bone pain is one of the most frequent kinds of chronic pain, mainly in elderly patients. It causes a significant worsening of functional capacity and deterioration in the quality of life in people affected. Mechanisms of pain in osteoporosis are poorly known and often extrapolated by other pathologies or other experimental model. One of principal causes would be a "hyper-remodeling" of bone, that involves osteoclasts activity and pathological modifications of bone innervation. Several studies show that osteoclasts play a significant role in bone pain etiol...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Use of opioids for treatment of osteoporotic pain.
Authors: Vellucci R, Mediati RD, Ballerini G
Abstract
The prevalence of osteoporosis increases markedly with age: currently it is estimated that over 200 million people suffer from osteoporosis worldwide. One of the most feared and more frequent complications of osteoporosis is pain, which affects 85% of patients. Commonly in the treatment of chronic pain the therapeutic strategy is based on a three-ladder approach, involving opioids for moderate and severe pain. As proposed by the World Health Organization (WHO), according to the intensity of chronic pain, analgesic treatment can be established. Despite t...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Clinical definition of sarcopenia.
Authors: Santilli V, Bernetti A, Mangone M, Paoloni M
Abstract
Sarcopenia is a condition characterized by loss of skeletal muscle mass and function. Although it is primarily a disease of the elderly, its development may be associated with conditions that are not exclusively seen in older persons. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength and it is strictly correlated with physical disability, poor quality of life and death. Risk factors for sarcopenia include age, gender and level of physical activity. In conditions such as malignancy, r...
Source: Clinical Cases in Mineral and Bone Metabolism - December 2, 2015 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
