Clinical Cases in Mineral and Bone Metabolism 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Densitometric evaluation of bone-prosthetic counterface in hip and knee arthroplasty with modern implants.
CONCLUSIONS: After a joint replacement a full adhesion of the prosthetic surface to the host bone should be achieved through a local biological process named osseointegration. In some cases this process may not fully realize, so the secondary stability of the implant may fail. DXA is a valuable tool to follow over time the bone remodelling at the bone-prosthesis counterface in THA and in rTKA, in order to early detect any alterations of such phenomenon.
PMID: 27920813 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Low-energy trauma-induced intercondylar femoral fracture.
We present a 44-year-old female patient with recurrent fragility fractures including an intercondylar femoral fracture and with normal planar bone densitometry. Diagnosis of hypophosphatasia was suggested by low volumetric cortical bone mineral density and laboratory findings. DNA sequencing revealed heterozygous mutations in the exons 5, 6 and 9 of the ALPL gene, thus confirming the suspected diagnosis.
PMID: 27920814 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Early onset acute tubular necrosis following single infusion of zoledronate.
We report the first occurrence of toxic acute tubular necrosis (ATN) following treatment with zoledronate in a patient with osteoporosis. A 63-year-old Caucasian female with rheumatoid arthritis on anti-immune agents received a single dose of zoledronic acid (reclast) for worsening osteoporosis. Twelve days later, she developed renal failure with a rise in serum creatinine from a baseline level of 1.1 mg/dL to 5.5 mg/dL. Renal biopsy showed toxic ATN. Zoledronate was discontinued and the patient had subsequent gradual improvement in renal function with final serum creatinine of 1.8 mg/dL at 1 month of follow up. Careful mo...
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis.
We report here a case of multiple extraspinal hyperostoses concomitant with marked osteoporosis and vitamin D deficiency in a patient taking acitretin for 20 years due to severe congenital lamellar ichthyosis.
PMID: 27920816 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
From the Editor-in-Chief.
Authors: Brandi ML
PMID: 27252735 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Algodystrophy: complex regional pain syndrome and incomplete forms.
Authors: Giannotti S, Bottai V, Dell'Osso G, Bugelli G, Celli F, Cazzella N, Guido G
Abstract
The algodystrophy, also known as complex regional pain syndrome (CRPS), is a painful disease characterized by erythema, edema, functional impairment, sensory and vasomotor disturbance. The diagnosis of CRPS is based solely on clinical signs and symptoms, and for exclusion compared to other forms of chronic pain. There is not a specific diagnostic procedure; careful clinical evaluation and additional test should lead to an accurate diagnosis. There are similar forms of chronic pain known as bone marrow edema syndro...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Hypercalcemia of advanced chronic liver disease: a forgotten clinical entity!
Authors: Kuchay MS, Mishra SK, Farooqui KJ, Bansal B, Wasir JS, Mithal A
Abstract
Hypercalcemia caused by advanced chronic liver disease (CLD) without hepatic neoplasia is uncommonly reported and poorly understood condition. We are reporting two cases of advanced CLD who developed hypercalcemia in the course of the disease. This diagnosis of exclusion was made only after meticulous ruling out of all causes of hypercalcemia. The unique feature of this type of hypercalcemia is its transient nature that may or may not require treatment. This clinical condition in patients with CLD should be kept in mind while...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Differences in monthly variation, cause, and place of injury between femoral neck and trochanteric fractures: 6-year survey (2008-2013) in Kyoto prefecture, Japan.
CONCLUSIONS: Based on the results of the present study, the injury pattern might not have a great effect on the susceptibility difference between neck and trochanteric fractures.
PMID: 27252738 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Comparison of the effects of eldecalcitol with either raloxifene or bisphosphonate on serum tartrate resistant acid phosphatase-5b, a bone resorption marker, in postmenopausal osteoporosis.
CONCLUSION: ELD combined with RLX or BP administered for 6 months to postmenopausal women with osteoporosis who were drug-naïve or who had switched medications significantly reduced and maintained TRACP-5b values within the reference range.
PMID: 27252739 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Use of MR-based trabecular bone microstructure analysis at the distal radius for osteoporosis diagnostics: a study in post-menopausal women with breast cancer and treated with aromatase inhibitor.
CONCLUSION: These findings suggest that the initial deterioration of trabecular bone microstructure as measured by MRI and BMD loss as measured by DXA occur not sequentially but rather simultaneously. Thus, the use of MR-based trabecular bone microstructure assessment is limited as early diagnostic biomarker in this clinical setting.
PMID: 27252740 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Clodronate news of efficacy in osteoporosis.
Authors: Nardi A, Ventura L, Cozzi L, Tonini G
Abstract
Clodronate belongs to Bisphosphonates family and it has been studied especially for osteoporosis treatment, Paget's disease, osteolytic metastases, hypercalcemia malignancy and some childhood skeletal diseases. Besides the osteoporosis treatment, it has been successfully used for treating tumoral osteolysis and for bone localization of multiple myeloma, hypercalcemia malignancy, primary hyperparathyroidism, Paget's disease and algodystrophy. Filipponi study showed a statistically significant reduction of the incidence of vertebral fractures after 4 ye...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Hyaluronan viscosupplementation: state of the art and insight into the novel cooperative hybrid complexes based on high and low molecular weight HA of potential interest in osteoarthritis treatment.
Authors: Schiraldi C, Stellavato A, de Novellis F, La Gatta A, De Rosa M
Abstract
Osteoarthritis (OA) represents a group of chronic, painful, disabling conditions affecting synovial joints. It is characterized by degeneration of articular cartilage, alterations of peri-articular and subchondral bone, low-grade synovial inflammation (synovitis). Despite OA is commonly described as a non-inflammatory disease, it is known that its progression and the subsequent increment of symptoms correlate to the production of inflammatory factors that induce the secretion of enzymes responsible for cartilage degradation. ...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Atraumatic intracapsular neck of femur fractures after prolonged bisphosphonate treatment: a new atypical variant?
We present 2 cases of elderly females presenting with atraumatic, near-vertical (Pauwells grade 3), intracapsular neck of femur fractures. Following diagnosis of osteoporosis on DEXA scans, they had received alendronic acid for 7 and 10 years respectively. Routine blood tests and serum estimations of calcium, vitamin-D and thyroid-stimulating hormone, done at admission, were within the normal ranges. These patients were managed with a hemiarthroplasty and a dynamic hip screw (DHS) respectively, following discontinuation of bisphosphonates. We present these 2 cases in light of emerging evidence that associates long-term bis...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Surgical prevention of femoral neck fractures in elderly osteoporotic patients. A literature review.
Authors: Chiarello E, Tedesco G, Cadossi M, Capra P, Terrando S, Miti A, Giannini S
Abstract
Fragility fractures of the femur are one of the major causes of morbidity and mortality worldwide. The incidence of new contralateral hip fractures in elderly osteoporotic patients ranges from 7 to 12% within 2 years after the first fracture. Secondary prevention can be divided in: pharmacological therapy based on the prescription of anti-osteoporotic drugs with different mechanism of action and non-pharmacological therapy which is based on modification of environmental risk factors, on a healthy diet with daily su...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Immobilization induced hypercalcemia.
Authors: Cano-Torres EA, González-Cantú A, Hinojosa-Garza G, Castilleja-Leal F
Abstract
Immobilization hypercalcemia is an uncommon diagnosis associated with increased bone remodeling disorders and conditions associated with limited movement such as medullar lesions or vascular events. Diagnosis requires an extensive evaluation to rule out other causes of hypercalcemia. This is a report of a woman with prolonged immobilization who presented with severe hypercalcemia. This case contributes to identification of severe hypercalcemia as a result of immobility and the description of bone metabolism during thi...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
