Clinical Cases in Mineral and Bone Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Detection of melorheostosis in a young lady with upper limb pain on Three Phase Bone Scintigram/SPECT-CT.
Authors: Hassan A, Khalid M, Khawar S Abstract Melorheostosis is a benign, noninheritable bone dysplasia characterized by its classic radiographic features of dense, flowing hyperostosis. It frequently affects one limb, usually the lower extremity and rarely the axial skeleton. A 26-year-old lady with obesity, polycystic ovarian syndrome and scalp dandruff presented with a long standing history of upper extremity pain and inability to adduct the arm completely. A Tc-99m MDP whole body and SPECT/CT scan performed for suspected fibrous dysplasia showed increased radiotracer uptake in densely sclerotic humera...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

An unusual case of hypercalcemia in a patient of concomitant hypoparathyroidism and celiac disease.
Authors: Somani S, Kotwal N, Upreti V Abstract Milk alkali syndrome has shown resurgence with increase in use of (prescription or non prescription) calcium supplements. Cases of iatrogenic vitamin D intoxication has also increased due to increasing use of high doses of injectable vitamin D formulations by physicians, surgeons, orthopaedicians, gynecologists and other specialties inadvertently. Here, we present an unusual case of a 17-year-old boy who presented with iatrogenic hypercalcemia as a result of combination of milk alkali syndrome with vitamin D intoxication despite being a case of hypoparathyroid...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Ossification of the cervical ligamentum flavum and osseous brown tumor: late manifestations of primary hyperparathyroidism misdiagnosed in a case of parathyroid carcinoma.
We describe the coexistence of rare late manifestations of HPT, which had not been adequately investigated at their onset in this young patient. Therefore, increased awareness is needed in order to recognize and further investigate signs or symptoms of HPT. PMID: 27252748 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Atypical femoral fractures bilaterally in a patient receiving bisphosphonate: a case report.
We describe simultaneous bilaterally femoral fractures in a 76-year-old woman. PMID: 27252749 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Asymmetrical bone loss in a patient with poliomyelitis: an indication for anti-osteoporotic therapy.
CONCLUSION: Poliomyelitis is an important acquired risk factor for regional osteoporosis. This condition should be detected and treated in this cohort of patients who are clearly at higher risk of fractures. PMID: 27252750 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Jaw tumor in primary hyperparathyroidism is not always a brown tumor.
We report a case of a HPT-JT syndrome to focus on the differential diagnosis with brown tumors. PMID: 27252751 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Efficacy of a specific rehabilitation protocol in postural control of a young woman with multiple fragility vertebral fractures: a case report.
Authors: Raffaetà G, Falossi F, Menconi A, Genovesi C, Mazzantini M, Bottai V, Guido G Abstract The fragility vertebral fractures have a considerable impact on an individual's health-related quality of life due to pain, limitations in activity, social participation, altered mood and balance impairment. Physiotherapy interventions may have an important role in improving quality of life, balance and reducing the fracture risk in people with osteoporotic vertebral fractures. In literature there are only a few studies that examine exercise interventions in osteoporotic populations with vertebral fracture and ...
Source: Clinical Cases in Mineral and Bone Metabolism - June 4, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

From the Editor-in-Chief.
Authors: Brandi ML PMID: 26811698 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - January 29, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

The pharmacological basis of opioids.
Authors: Ghelardini C, Di Cesare Mannelli L, Bianchi E Abstract An opioid is a chemical that binds to opioid receptors, which are widely distributed in the central and peripheral nervous system and gastrointestinal tract. The different effects elicited by activation of these receptors are due to their specific neuronal and extraneuronal distribution. The painkiller effect of opioids is induced by the synergy of the two events, namely reduction of pain threshold and emotional detachment from pain. The opioid effects transcending analgesia include sedation, respiratory depression, constipation and a strong s...
Source: Clinical Cases in Mineral and Bone Metabolism - January 29, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Update on vitamin D: pros and cons.
Authors: Cipriani C, Piemonte S, Cilli M, Pepe J, Minisola S Abstract Controversies on vitamin D currently represent a challenging topic in mineral metabolism research. In particular, current guidelines on vitamin D supplementation did not report consistent recommendation and the issue related to beneficial vs harmful effects of loading vitamin D doses did not lead to any firm universal conclusion. Finally, serum and clinical outcomes of vitamin D supplementation, particularly as far as extra-skeletal effect of the hormone, need to be further investigated. PMID: 26811700 [PubMed] (Source: Clinical...
Source: Clinical Cases in Mineral and Bone Metabolism - January 29, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Osteogenic differentiation of adipose tissue-derived mesenchymal stem cells on nanostructured Ti6Al4V and Ti13Nb13Zr.
Authors: Marini F, Luzi E, Fabbri S, Ciuffi S, Sorace S, Tognarini I, Galli G, Zonefrati R, Sbaiz F, Brandi ML Abstract Bone tissue engineering and nanotechnology enable the design of suitable substitutes to restore and maintain the function of human bone tissues in complex fractures and other large skeletal defects. Long-term stability and functionality of prostheses depend on integration between bone cells and biocompatible implants. Human adipose tissue-derived mesenchymal stem cells (hAMSCs) have been shown to possess the same ability to differentiate into osteoblasts and to produce bone matrix of clas...
Source: Clinical Cases in Mineral and Bone Metabolism - January 29, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Serum 25-hydroxy vitamin D levels in patients with acne vulgaris and its association with disease severity.
CONCLUSION: Based on the previous studies this is highly suspected that vitamin D would be a prominent factor in acne patients and more performances with bigger sample size could be useful to get positive results. PMID: 26811702 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - January 29, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Three-dimensional parametric mapping in quantitative micro-CT imaging of post-surgery femoral head-neck samples: preliminary results.
Authors: Giannotti S, Bottai V, Panetta D, De Paola G, Tripodi M, Citarelli C, Dell'Osso G, Lazzerini I, Salvadori PA, Guido G Abstract Osteoporosis and pathological increased occurrence of fractures are an important public health problem. They may affect patients' quality of life and even increase mortality of osteoporotic patients, and consequently represent a heavy economic burden for national healthcare systems. The adoption of simple and inexpensive methods for mass screening of population at risk may be the key for an effective prevention. The current clinical standards of diagnosing osteoporosis and...
Source: Clinical Cases in Mineral and Bone Metabolism - January 29, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Total hip replacement in osteoarthritis: the role of bone metabolism and its complications.
Authors: Bottai V, Dell'Osso G, Celli F, Bugelli G, Cazzella N, Cei E, Guido G, Giannotti S Abstract Osteoarthritis is one of the most common joint disorder. For treatment of hip symptomatic osteoarthritis, when conservative medical therapy has failed, total hip arthroplasty (THA) is a successful orthopaedic procedures that reduces pain and improves function and quality of life. Incidence of osteoarthritis is constantly increasing with raising life expectancy. This aging process also has led to an increasing number of patients with osteoporosis who need hip replacement for osteoarthritis. Osteoporosis have...
Source: Clinical Cases in Mineral and Bone Metabolism - January 29, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Normalization of bone mineral density after five years of treatment with strontium ranelate.
Authors: Sánchez JA Abstract E.F., female, age 58, mother of 4 children and otherwise healthy, had gone into menopause when she was 42. She had received hormone replacement therapy during 8 years. Due to low bone mass she had been treated with oral alendronate during 7 years. She had a normal calcium intake in her diet and engaged in regular physical activity. She did not smoke, and drank alcohol only occasionally. Her mother had sustained a hip fracture at age 90. Bone densitometry of her lumbar spine by DXA showed a T-score of -3.0; standardized bone mineral density (sBMD) had decreased by 11% in the pr...
Source: Clinical Cases in Mineral and Bone Metabolism - January 29, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research