Clinical Cases in Mineral and Bone Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Non-unions.
Authors: Calori GM, Mazza EL, Mazzola S, Colombo A, Giardina F, Romanò F, Colombo M Abstract Non-union of long bones is a significant consequence of fracture treatment. Bone regeneration is a complex physiological process of bone formation which can be seen during normal fracture healing. An improved understanding of the molecular and cellular events that occur during bone repair and remodelling has led to the development of biologic agents that can augment the biological microenvironment and enhance bone repair. Currently, there are different strategies to augment the impaired or "insufficient" bone-rege...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Periprosthetic fractures: epidemiology and current treatment.
Authors: Capone A, Congia S, Civinini R, Marongiu G Abstract Periprosthetic fractures are becoming increasingly frequent due to aging population and growing number of total joint replacements involving joints different from hip and knee, such as shoulder and elbow. The treatment of these fractures still represents one of the major challenges for the orthopedic surgeon. Despite all efforts to understand and treat these patients, high rate of failure and mortality are still reported. In this review, the epidemiology of periprosthetic fractures, risk factors and results of surgical treatment are disclosed. Mo...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Orthopaedic procedures in haemophilia.
Authors: Rizzo AR, Zago M, Carulli C, Innocenti M Abstract Haemophilia may nowadays be considered an "ortho paedic" disease given due to the involvement of musculoskeletal system in almost all haemophilic subjects. The modern haematological prophylaxis has dramatically improved the quality of life reducing bleedings and life-threatening complications; however, joint bleedings, progressive and irreversible arthropathy and osteoporosis are still now common challenging issues to be faced. One of the tissues involved by Haemophilia is the bone, particularly in the periarticular zone: poor bone quality and decr...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Vitamin K and bone.
Authors: Fusaro M, Mereu MC, Aghi A, Iervasi G, Gallieni M Abstract Vitamin K is mainly known as an agent involved in blood coagulation, maintaining the activity of coagulation factors in the liver. In addition, epidemiological studies suggested that a lack of vitamin K is associated with several diseases, including osteoporosis and vascular calcification. There are two main kinds of vitamin K: Phylloquinone (or PK) and Menaquinones (MKn), both act as co-enzyme of y-glutamyl carboxylase (GGCX) transforming under-carboxylated in carboxylated vitamin K dependent proteins, such as Bone Gla Protein (or Osteoca...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Oral calcidiol is a good form of vitamin D supplementation.
Authors: Biondi P, Pepe J, Biamonte F, Occhiuto M, Parisi M, Demofonti C, Baffa V, Minisola S, Cipriani C Abstract Vitamin D supplementation represents an important topic in the field of metabolic bone disease. Calcidiol, the 25-hydroxy-vitamin D [25(OH)D], is the form of vitamin D most recently introduced in clinical practice. Advantages of the use of calcidiol derive from the pharmacokinetic properties and are related to the possibility of use in patients with liver disease, obese patients, patients with intestinal malabsorption, secondary hyperparathyroidism associated with chronic kidney disease as wel...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Oxidative stress in bone remodeling: role of antioxidants.
Authors: Domazetovic V, Marcucci G, Iantomasi T, Brandi ML, Vincenzini MT Abstract ROS are highly reactive molecules which consist of a number of diverse chemical species, including radical and non-radical oxygen species. Oxidative stress occurs as a result of an overproduction of ROS not balanced by an adequate level of antioxidants. The natural antioxidants are: thiol compounds among which GSH is the most representative, and non-thiol compounds such as polyphenols, vitamins and also various enzymes. Many diseases have been linked to oxidative stress including bone diseases among which one of the most imp...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Adipose stem cells for bone tissue repair.
Authors: Ciuffi S, Zonefrati R, Brandi ML Abstract Adipose-derived stem/stromal cells (ASCs), together with adipocytes, vascular endothelial cells, and vascular smooth muscle cells, are contained in fat tissue. ASCs, like the human bone marrow stromal/stem cells (BMSCs), can differentiate into several lineages (adipose cells, fibroblast, chondrocytes, osteoblasts, neuronal cells, endothelial cells, myocytes, and cardiomyocytes). They have also been shown to be immunoprivileged, and genetically stable in long-term cultures. Nevertheless, unlike the BMSCs, ASCs can be easily harvested in large amounts with m...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Hypocalcemia and osteomalacia after bariatric surgery.
Conclusion: Our case highlights the possible consequences that bariatric surgery may have on bone and mineral health and the need for regular and proactive follow-up of the patients. PMID: 29263738 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Hypophosphatasia: clinical manifestation and burden of disease in adult patients.
Authors: Conti F, Ciullini L, Pugliese G Abstract Hypophosphatasia (HPP) is a rare inherited disease with a heterogeneous clinical expression. The adult form of HPP is often difficult to be recognized with a delayed diagnosis and inappropriate treatments. Though severity of HPP decreases with age at onset, important complications could occur at any age and the burden of HPP among adult patients is found to be significant. Adult patients with HPP suffer of chronic pain, recurrent fractures and other orthopedics problems, with severe disability that have a serious negative impact on all aspects of their life...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Nuclear magnetic resonance therapy (MBST) in the treatment of osteoporosis. Case report study.
Authors: Krpan D, Kullich W Abstract Despite various pharmacological treatments, the problem of osteoporosis is not yet solved nor decreased. Drug's adverse event and fractures after long termed pharmacotherapy indicate a need for new treatment modalities. Nuclear magnetic resonance therapy could be a supplement to exercise and an alternative or supplement to pharmacotherapy. Number of clinical studies showed increase of BMD after nuclear magnetic resonance therapy and here presented case reports of eleven well-documented cases in which patients experienced severe trauma, having a huge hematoma around the ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Atypical presentation of spine bone metastasis in prostate cancer mimicking Pott's disease.
Authors: Flais J, Coiffier G, Brillet E, Perdriger A, Guggenbuhl P Abstract A 55-year-old man was hospitalized for a low back pain lasting for 3 months. Spinal MRI revealed a suggestive aspect of multilevel discitis L5-S1-S2 with paravertebral abscess. A thoraco-abdominal CT scan confirmed the presence of multiple pathological lymph nodes in several locations, bilateral micronodular pulmonary infiltrate; it also showed mirror bone erosions of vertebral L5 and S1 endplates, suggestive of disseminated tuberculosis with lung involvement and lymphadenopathy. A discovertebral L5-S1 biopsy was performed confirmi...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Infantile myofibromatosis of the iliac bone.
Conclusion: To our knowledge, this is the first case of solitary IM of the iliac bone, occurring 12 years after the first localization. Total resection resulted in excellent outcome. However recurrence can happen even long time after the first resection and new localization is possible, as in our case. This suggests close follow-up and clear information about the risk of recurrence. PMID: 29263742 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Hypercalcemia, necrotizing pancreatitis and bone lesions: a benign cause.
We report a case of PHPT in a young male patient. He presented with severe pancreatitis due to hypercalcemia and multiple bone lesions resulting in pathological fractures. The patients recovered rapidly after parathyroidectomy. PMID: 29263743 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Primary central nervous system germinal center B-like diffuse large B-cell lymphoma: a case report.
We report a case of a 54-year-old HIV-negative female who presented with a 2-month history of ongoing post meridiem low-level fever and new onset progressive paralysis. On MRI (magnetic resonance imaging), an infiltrative enhancing lesion was noted, which initially resembled that of MS, but she reacted not sensitively with immunosuppressive therapy, we performed a brain biopsy to her, it turned out to be primary CNS (central nervous system) diffuse large B-cell lymphoma (DLBCL). And the morphology, the flow cytometric findings were consistent with germinal center B-like diffuse large B-cell lymphoma. There were only a few ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Two cases of Gorham-Stout disease with good response to zoledronic acid treatment.
Authors: Brance ML, Castiglioni A, Cóccaro N, Palatnik M Abstract Gorham-Stout disease - also called vanishing bone syndrome - is a rare bone disease characterized by a progressive intra-osseous proliferation of non-neoplastic vascular tissue resulting in massive osteolysis. Here, we report two clinical cases of Gorham-Stout disease. Case 1: a 56-year-old woman with 20 years of history of pain and swell in elbows, ankles and wrist. Then she was diagnosed as systemic lupus erythematosus (SLE) with glomerulonephritis type III. After other pathologies were ruled out Gorham-Stout disease was diagnosed. Intrav...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research