Clinical Cases in Mineral and Bone Metabolism 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Safety and effectiveness of teriparatide vs alendronate in postmenopausal osteoporosis: a prospective non randomized clinical study.
Authors: Caggiari G, Leali PT, Mosele GR, Puddu L, Badessi F, Doria C
Abstract
In this work we study the safety and effectiveness of teriparatide and alendronate in patients with postmenopausal osteoporosis at high risk of fracture; it was a double-blinded and it was done by examining the comparisons between teriparatide 20 μg/day and alendronate 10 mg/day. Safety and effectiveness analyses were based on data from 355 woman with a mean age of 68 years. Two groups (A and B) with T-score ≤-2.5 at bone mineral density were analyzed and 3 or more vertebral fractures on radiograph. Group A: was treated with ...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
"Atypical" atypical femur fractures and use of bisphosphonates.
CONCLUSION: We propose that these periosteal reactions of the subtrochanteric femur are in fact AFFs with uncommon medial localization and could hence be considered "atypical" AFFs. We recommend being alert of AFFs in patients with bone pain and medial subtrochanteric lesions. More epidemiological studies are needed to investigate the occurrence of both medial and lateral AFFs and to gain more insight into its frequency and pathogenesis.
PMID: 28228783 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Atypical periprosthetic acetabular fracture in long-term alendronate therapy.
We report a atypical acetabular periprosthetic fracture in a 83-year-old female patient after prolonged alendronate treatment for osteoporosis and isolated acetabular revision surgery. The patient underwent to clinical, bioumoral and radiological evaluation and all the history cases were fully reported. We believe this periprosthetic fracture, according to the available data, may have similar underlying pathology to atypical femoral fractures. Awareness of symptoms, in addition to a regular radiographic survey may facilitate early diagnosis and possible prevention of spontaneous periprosthetic fractures, in patients receiv...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions.
CONCLUSIONS: Through the use of stem cells a greater ossification of the residual cavity (85-90%) was observed at 12 months after surgical enucleation in contenitive defects.
PMID: 28228785 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Hydroxyapatite in total hip arthroplasty. Our experience with a plasma spray porous titanium alloy/hydroxyapatite double-coated cementless stem.
CONCLUSIONS: Concerning the use of porous titanium alloy/hydroxyapatite double coating, this study reported an excellent implant survival rate in a mid-term period with a rate of 1,64% of subsidence in patients with type C of femoral canal but with an optimal HHS and Womac Score results. Regarding this stem, primary stability is guaranteed by trapezoid shape of proximal region and tapering in frontal plane through press-fit technique. Radiological absence of pedestal has been accepted as sign of no excessive stress transmission to distal cortex due to its tapered diaphyseal region. Thanks to the reported data, Authors can ...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Fix and replace; an emerging paradigm for treating acetabular fractures.
Authors: Murphy CG, Carrothers AD
Abstract
Although technically challenging even for the experienced surgeon, simultaneous open reduction and internal fixation (ORIF) of acetabular fracture and total hip replacement (THR) have some potential advantages over the more traditional treatment options in specific patient subgroups; theoretically allowing immediate weight bearing and faster rehabilitation, reducing the cost of inpatient stay, and reducing the risks of early and late local complications associated with standard treatment for this type of injury. We review the evolution of the indications and techn...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Safety and efficacy of vertebroplasty in the treatment of osteoporotic vertebral compression fractures: a prospective multicenter international randomized controlled study.
CONCLUSIONS: Pain relief and improvement of mobility and function after PV is immediate and significantly better in the short term compared with non-surgical care treatment.
PMID: 28228788 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Long-term outcome of grade III and IV chondral injuries of the knee treated with Steadman microfracture technique.
CONCLUSIONS: The study has shown significant clinical improvements in patients, despite the fact that indications to the use of microfracture are still very limited and selective. It's essential to underline the importance of the single patient assessment process, taking into account a variety of aspects including the site, the number and extent of the lesion, the degree of functionality, activity level, age and previous trauma. This shows the importance of a comprehensive assessment of the patient in order to choose the most suitable surgical option, which not necessarily has to strictly adhere to standard practice.
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Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Successful neridronate therapy in pregnancy-associated osteoporosis.
Authors: Gaudio A, Fiore CE
Abstract
Pregnancy-associated osteoporosis is a rare condition. The pathogenesis is probably multifactorial but has not yet been completely clarified. In this case report, a 38-year-old woman was referred to hospital after suffering an acute, non-traumatic back pain one month after delivering her first child. The radiological examination revealed four vertebral fractures. Bone mineral density was reduced, particularly at spine level. Biochemical tests were within normal range, except for increased urinary deoxypyridinoline and a slight reduction of the serum 25-OH vitamin D leve...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Two cases of pregnancy- and lactation- associated osteoporosis successfully treated with denosumab.
Authors: Sánchez A, Zanchetta MB, Danilowicz K
Abstract
Case 1. A 35-year-old woman in the 8(th) month of her first pregnancy suffered acute lumbar pain that persisted for 4 months. In the 5(th) month postpartum an acute increase in the low back pain led to a MRI which showed recent deformity in L1 and deformities of undetermined time of evolution in L2, L4, and L5. Laboratory evaluation did not reveal metabolic derangements. She had low bone mineral density (BMD, DXA) and severe deterioration of the microarchitecture of distal appendicular bone (HR-pQCT). Kyphoplasty of all 4 vertebrae was performed in 2...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Malabsorption syndrome as a rare cause of nephrocalcinosis.
We report a 35-year-old female with nephrocalcinosis. She had fitful steatorrhea since last year. Physical examination was normal. Analytic exams found normal renal function and ionogram. Primary hyperparathyroidism, renal tubular acidosis and sarcoidosis were excluded. Urinalysis showed mild hematuria, without proteinuria and 24-hour urine collection exhibited hyperoxaluria. Patient was submitted to an endoscopy and duodenal biopsy whose histology sustained the diagnosis of celiac disease. Fluid intake increase and gluten and oxalate free diet were initiated.
PMID: 28228792 [PubMed - in process] (Source: Clinical ...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Craniofacial fibrous dysplasia Report of a case with diverse radiological spectrum.
Authors: Punyani SR, Srivastava S, Jasuja VR
Abstract
A young male of Asian-Indian ethnicity reported with a complaint of a painless, slow growing swelling over the left side of lower jaw. A thorough clinical history was taken and detailed radiological exam performed. The conventional radiographic examination revealed a mixed radiolucent-radiopaque lesion with unique appearances on different radiographs. Additional computed tomographic examination discovered the involvement of several bones in the skull base. Subsequent to histopathological confirmation a final diagnosis of craniofacial fibrous dysplasia w...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Prompt clinical and biochemical response to denosumab in a young adult patient with craniofacial fibrous dysplasia.
CONCLUSION: Denosumab appears to be effective in reducing bone turnover and bone pain in adult patients with active MFD.
PMID: 28228794 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Bone scintigraphy of severe hypercalcemia following simvastatin induced rhabdomyolysis.
We present a patient with high dose simvastatin induced rhabdomyolysis leading to late onset of severe hypercalcemia due to calcium phosphate deposition in muscles diagnosed by distinctive bone scintigraphy. A 60-year-old Asian male was admitted to the hospital for profound weakness one week following the initiation of simvastatin 80 mg daily post myocardial infarction. His clinical course was complicated by contrast nephropathy. One week later, he developed progressive weakness in all his extremities and inability to raise his head and eat. Simvastatin was discontinued at this point. CPK elevation to greater than 425,000 ...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Recurrent diabetic ketoacidosis: a rare presenting manifestation of primary hyperparathyroidism.
We report a rare case of primary hyperparathyroidism in a young female who presented with recurrent diabetic ketoacidosis. The patient had suffered an episode of acute pancreatitis in the past. On evaluation patient was found to have primary hyperparathyroidism and after removal of left inferior parathyroid adenoma her insulin requirement decreased by twelve units.
PMID: 28228796 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
