Clinical Cases in Mineral and Bone Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Femoral neck's fracture in Fahr's Syndrome: case report.
We describe a case of a 76-year-old male patient underwent reduction and fixation of a subtrochanteric fracture with intramedullary nail. During post-operative rehabilitation therapists's patient management was difficult due to obvious extrapyramidal symptoms characterized by dysarthria, rigidity, bradykinesia, postural instability. A CT scan, performed for the onset of stiffness and confusion before the operation, showed: IV ventricle eumorphic and in axis; expansion in atrophic sense of supratentorial ventricular system; bilateral, diffuse and coarse calcifications of the basal ganglia in the cerebellar and occipital cor...
Source: Clinical Cases in Mineral and Bone Metabolism - February 24, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

From the Editor-in-Chief.
Authors: Brandi ML PMID: 27920799 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Calcio, vitamina D e fratture: domande e risposte.
Authors: Brandi ML PMID: 27920800 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Implications of analgesics use in osteoporotic-related pain treatment: focus on opioids.
Authors: Vellucci R, Mattia C, Celidonio L, Mediati RD Abstract Bone loss is asymptomatic and will progress without pain and other symptoms until the occurrence of a fracture. The occurrence of a breaking bone induce acute pain determined and supported by a mechanical, inflammatory and neuropathic component. Very often the acute component evolves in a chronic musculoskeletal component. Overall objectives of the analgesic therapy can be summarized in pain relief, improving sleep, improve mobility, reduce anxiety, emotional component and depression. Osteoporosis is predominantly a condition of the elderly, m...
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

The role of drugs in bone pain.
CONCLUSION: In the daily struggle that doctors face to treat their patients, pain management should not be disregarded. Among the various types of pain, bone pain, must not be underestimated but be fought against by using all means available. Patients need to be treated depending on the severity of their pain, NSAIDs should be the preferred choice of treatment for acute pain but not for that of chronic pain. In the case of chronic pain opioids should be used in their most recent fomulations as they can guarantee fewer side effects. Patients should also be prescribed adjuvant drugs as well as being given psychological suppo...
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Bone pain mechanism in osteoporosis: a narrative review.
Authors: Mattia C, Coluzzi F, Celidonio L, Vellucci R Abstract Bone pain in elderly people dramatically affects their quality of life, with osteoporosis being the leading cause of skeletal related events. Peripheral and central mechanisms are involved in the pathogenesis of the nervous system sensitization. Osteoporosis in the elderly has been associated with increased density of bone sensory nerve fibers and their pathological modifications, together with an over-expression of nociceptors sensitized by the lowering pH due to the osteoclastic activity. The activation of N-methyl-D-aspartate (NMDA) receptor...
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Bone healing in 2016.
This article reviews the current applications and supporting evidence for the use of these therapies in the enhancement of fracture healing. PMID: 27920804 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Abaloparatide.
Authors: Gonnelli S, Caffarelli C Abstract Abaloparatide is an investigational analog of human PTHrP (1-34) being developed for the treatment of osteoporosis. The amino-acid sequence of abaloparatide is identical to that of PTHrP in the first 20 amino-acids, while over half of the remaining amino-acids are different. Some studies in animals and in humans reported that abaloparatide presented a potent anabolic activity with reduced effects on bone resorption as compared to that observed with teriparatide. This may be due to a more transient signaling response of abaloparatide related to differing affinities...
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern.
In conclusion, HME is a complex disease where the paediatrician, the geneticist and the orthopaedic surgeon play an interchangeable role in diagnosis, research and therapy. We are waiting for new studies able to explain better the role of HS in signal transduction, because it plays a role in other bone and cartilage diseases (in particular malignant degeneration) as well as in skeletal embryology. PMID: 27920806 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Underdiagnosis of osteoporotic vertebral fractures in patients with fragility fractures: retrospective analysis of over 300 patients.
We examined 478 patients at our outpatient clinic, who were referred for fragility fracture occurrence. The most common fragility fractures was hip fractures. However, after execution of spine X-rays in patients who had sustained hip fracture, we found that a large proportion of them had VF, which had not been reported in their medical history. PMID: 27920807 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Risk factors of mortality during the first year after low energy osteoporosis fracture: a retrospective case-control study.
CONCLUSION: Patients died more often from their co-morbidities than direct complications of their fractures. Osteoporotic fracture seems to be a marker of poor health status and a factor which may hasten the death. PMID: 27920808 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Rates and reasons for lack of persistence with anti-osteoporotic drugs: analysis of the Campania region database.
Authors: Iolascon G, Gimigliano F, Moretti A, Riccio I, Di Gennaro M, Illario M, Monetti VM, Orlando V, Menditto E Abstract Subjects with chronic diseases are more likely to be nonpersistent to pharmacological treatment. Lack of persistence is common among subjects using oral anti-osteoporotic drugs, and leads to increased risk of fragility fracture. The aim of our retrospective study is to analyze the rates and reasons for discontinuation of anti-osteoporotic drugs in the Campania Region. Subjects aged over 40 years were included if they had received at least one prescription for any anti-osteoporotic dru...
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Hyaluronic acid in the management of osteoarthritis: injection therapies innovations.
Authors: Santilli V, Paoloni M, Mangone M, Alviti F, Bernetti A Abstract Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Viscosupplementation with intra-articular (IA) hyaluronic acid (HA) could be a treatment option in OA, however recommendations made in different international guidelines for the non-surgical management of OA are not always concordant with regard to the role of IA injection therapies. Results from a recent Italian Consensus Conference underline how IA-HA to treat OA represents a widely used therapy in Italy. Specific...
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

The use of routine non density calibrated clinical computed tomography data as a potentially useful screening tool for identifying patients with osteoporosis.
CONCLUSIONS: CT attenuation values of the first lumbar vertebra can be measured on routine abdomen CTs with limited variability despite multiple readers and scanners. Correlation between HU and BMD as measured by DXA scan was only weakly positive, and by this method measuring the density of a lumbar vertebral body from a routine MDCT scan does not provide the sensitivity or specificity necessary for a screening test. However above a certain measured value (180 HU), patients have a low chance of osteoporosis and therefore may not need additional screening, potentially limiting radiation exposure and cost. PMID: 2792...
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research

Evaluation of the bone mineral density of the subjects with avascular necrosis of hip joint.
CONCLUSION: As there is no difference between the BMD of femur in Perthes side, it can be concluded that the deformation of femur in these subjects may not be due to a change in BMD. PMID: 27920812 [PubMed - in process] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - December 8, 2016 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research