Periodontitis and bone metabolism.

Periodontitis and bone metabolism. Clin Cases Miner Bone Metab. 2015 May-Aug;12(2):174-177 Authors: Barbato L, Francioni E, Bianchi M, Mascitelli E, Marco LB, Tonelli DP Abstract Periodontitis is a plaque induced disease characterized by tissue destruction. The extent of the alveolar bone loss depends on the host response stimulated by bacterial infection. Recently researchers have focused on the role of the immune system, of RANK/RANKL/OPG pathway and of cytokines network. Another recent field of interest is osteoimmunology that try to explain the relationship between immune and bone cells in activating bone resorption. Advances in the understanding of the pathogenic mechanisms allowed a better understanding of the relationship with other diseases like osteoporosis and also to hypothesize new therapies based on modulation of host response (host modulatory therapy - HMT). The purpose of this mini-review is to briefly discuss these topics. PMID: 26604945 [PubMed - as supplied by publisher]
Source: Clinical Cases in Mineral and Bone Metabolism - Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research