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A perspective on multi-target drug discovery and design for complex diseases
Diseases of infection, of neurodegeneration (such as Alzheimer ’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identif... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 17, 2018 Category: Internal Medicine Authors: Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi and Maria Laura Bolognesi Tags: Perspective Source Type: research

Anti-inflammatory and antiplatelet effects of non-vitamin K antagonist oral anticoagulants in acute phase of ischemic stroke patients
Recently, non-vitamin K antagonist oral anticoagulants such as direct thrombin and direct factor Xa inhibitors have been prescribed for prevention of embolic stroke. While in Japan, argatroban, also a direct t... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 12, 2018 Category: Internal Medicine Authors: Taizen Nakase, Junta Moroi and Tatsuya Ishikawa Tags: Research Source Type: research

Does ALK-rearrangement predict favorable response to the therapy of bevacizumab plus pemetrexed in advanced non-small-cell lung cancer? Case report and literature review
Advanced ALK-rearranged non-small cell lung cancer (NSCLC) patients will develop acquired resistance after anaplastic lymphoma kinase (ALK) inhibitors therapies. Vascular endothelial growth factor-A (VEGF-A) p... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 9, 2018 Category: Internal Medicine Authors: Zhichao Liu, Youting Bao, Butuo Li, Xindong Sun and Linlin Wang Tags: Case report Source Type: research

Using single-cell multiple omics approaches to resolve tumor heterogeneity
It has become increasingly clear that both normal and cancer tissues are composed of heterogeneous populations. Genetic variation can be attributed to the downstream effects of inherited mutations, environment... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 28, 2017 Category: Internal Medicine Authors: Michael A. Ortega, Olivier Poirion, Xun Zhu, Sijia Huang, Thomas K. Wolfgruber, Robert Sebra and Lana X. Garmire Tags: Review Source Type: research

The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment
Extracellular vesicles (EVs) are membranous vesicles released from almost all type of cells including cancer cells. EVs transfer their components, such as microRNAs (miRNAs), messenger RNAs, lipids and protein... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 13, 2017 Category: Internal Medicine Authors: Fumihiko Urabe, Nobuyoshi Kosaka, Yusuke Yoshioka, Shin Egawa and Takahiro Ochiya Tags: Review Source Type: research

Cancer nanomedicine: a review of recent success in drug delivery
Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment, the problem is selectively killing all the cancer c... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 11, 2017 Category: Internal Medicine Authors: Stephanie Tran, Peter-Joseph DeGiovanni, Brandon Piel and Prakash Rai Tags: Review Source Type: research

Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia
Monozygotic twins are valuable in assessing the genetic vs environmental contribution to diseases. In the era of complete genome sequences, they allow identification of mutational mechanisms and specific genes... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 28, 2017 Category: Internal Medicine Authors: C. A. Castellani, M. G. Melka, J. L. Gui, A. J. Gallo, R. L. O ’Reilly and S. M. Singh Tags: Research Source Type: research

Heterogeneity in retinoblastoma: a tale of molecules and models
Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 9, 2017 Category: Internal Medicine Authors: Sonya Stenfelt, Maria K. E. Blixt, Charlotta All-Ericsson, Finn Hallb öök and Henrik Boije Tags: Review Source Type: research

Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia
Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 3, 2017 Category: Internal Medicine Authors: Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong and Xu Peng Tags: Short report Source Type: research

Early clinical experiences with nintedanib in three UK tertiary interstitial lung disease centres
Nintedanib has been shown to slow disease progression in patients with idiopathic pulmonary fibrosis (IPF). It was approved by the National Institute for Health and Care Excellence (NICE) in January 2016 for I... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 3, 2017 Category: Internal Medicine Authors: Hannah Toellner, G. Hughes, W. Beswick, M. G. Crooks, C. Donaldson, I. Forrest, S. P. Hart, C. Leonard, M. Major, A. J. Simpson and N. Chaudhuri Tags: Research Source Type: research

Proteomics in asthma: the clinicians were right after all, were not they?
Clinical disease phenotypes with underlying information of molecular and biological signatures for the same, is a prerequisite for improving medical care and developing more effective, stratified management st... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 27, 2017 Category: Internal Medicine Authors: Anirban Sinha and Peter J. Sterk Tags: Commentary Source Type: research

Optimization of culture conditions for rapid clinical-scale expansion of human umbilical cord blood-derived mesenchymal stem cells
Mesenchymal stem cells (MSCs) have broad-spectrum therapeutic effects in various diseases, and thus have many clinical applications. However, it is difficult to produce sufficient numbers of MSCs for clinical ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 10, 2017 Category: Internal Medicine Authors: Wankyu Choi, Soon-Jae Kwon, Hye Jin Jin, Sang Young Jeong, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon and Eun Su Jeon Tags: Research Source Type: research

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib
Serial analysis of biomarkers in the circulation of patients undergoing treatment ( “liquid biopsies”) can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic ac... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 4, 2017 Category: Internal Medicine Authors: Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs and Anton Wellstein Tags: Research Source Type: research

Extracellular vesicles: how they interact with endothelium, potentially contributing to metastatic cancer cell implants
Extracellular vesicles (EV) are blebs of cellular membranes, which entrap small portions of subjacent cytosol. They are released from a variety of cells, circulate in the blood for an unknown length of time an... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 21, 2017 Category: Internal Medicine Authors: Murray M. Bern Tags: Review Source Type: research

Expression of Concern to: Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation
The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 18, 2017 Category: Internal Medicine Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam Tags: Erratum Source Type: research