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Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction
Fetal growth restriction (FGR) contributes the primary cause of perinatal mortality and morbidity with impacts on the long-term health. To determine the core gene expression network and gene signatures, which ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 28, 2020 Category: Internal Medicine Authors: Guiying Wang, Jun Yu, Yiwei Yang, Xiaoqin Liu, Xiaobo Zhao, Xudong Guo, Tao Duan, Chenqi Lu and Jiuhong Kang Tags: Research Source Type: research

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression
The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone a... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 28, 2020 Category: Internal Medicine Authors: Hongyu Zhao, Yunfei Wang, Chao Yang, Junhu Zhou, Lin Wang, Kaikai Yi, Yansheng Li, Qixue wang, Jin Shi, Chunsheng Kang and Liang Zeng Tags: Research Source Type: research

Detection of bladder cancer using urinary cell-free DNA and cellular DNA
The present study sought to identify a panel of DNA markers for noninvasive diagnosis using cell-free DNA (cfDNA) from urine supernatant or cellular DNA from urine sediments of hematuria patients. A panel of 4... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 14, 2020 Category: Internal Medicine Authors: Zhenyu Ou, Kai Li, Ting Yang, Ying Dai, Mohan Chandra, Jun Ning, Yongli Wang, Ran Xu, Tangjie Gao, Yu Xie, Qing He, Yuanwei Li, Qin Lu, Long Wang and Zhuo Song Tags: Research Source Type: research

RANKL/RANK promotes the migration of gastric cancer cells by interacting with EGFR
The incidence and mortality rates of gastric cancer (GC) rank in top five among all malignant tumors. Chemokines and their receptor-signaling pathways reportedly play key roles in the metastasis of malignant t... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 13, 2020 Category: Internal Medicine Authors: Xing Wan, Yongxi Song, Honghong Fang, Ling Xu, Xiaofang Che, Shuo Wang, Xiaomeng Zhang, Lingyun Zhang, Ce Li, Yibo Fan, Kezuo Hou, Zhi Li, Xueqing Wang, Yunpeng Liu and Xiujuan Qu Tags: Research Source Type: research

Systems biology approaches toward autosomal dominant polycystic kidney disease (ADPKD)
In this study, we have re-analyzed a microarray... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 6, 2020 Category: Internal Medicine Authors: Ilnaz Rahimmanesh and Razieh Fatehi Tags: Research Source Type: research

The prognostic value of integration of pretreatment serum amyloid A (SAA) –EBV DNA (S-D) grade in patients with nasopharyngeal carcinoma
Serum amyloid A (SAA) has been associated with the development and prognosis of cancer. The purpose of this study was to evaluate the predictive value of integration of pretreatment SAA –EBV DNA (S-D) grade and... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 6, 2020 Category: Internal Medicine Authors: Jianpei Li, Changchun Lai, Songguo Peng, Hao Chen, Lei Zhou, Yufeng Chen and Shulin Chen Tags: Research Source Type: research

Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment
Despite the well described heterogeneity in glioblastoma (GBM), treatment is standardized, and clinical trials investigate treatment effects at population level. Genomics-driven oncology for stratified treatme... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 30, 2019 Category: Internal Medicine Authors: Erlend Skaga, Evgeny Kulesskiy, Marit Brynjulvsen, Cecilie J. Sandberg, Swapnil Potdar, Iver A. Langmoen, Aki Laakso, Em ília Gaál-Paavola, Markus Perola, Krister Wennerberg and Einar O. Vik-Mo Tags: Research Source Type: research

Mesenchymal stem cell –gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect
Several investigations affirm that, patients with inflammatory bowel disease (IBD) exhibit dysbiosis characterized by restricted biodiversity and imbalanced bacterial composition intertwined with immune dysreg... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 23, 2019 Category: Internal Medicine Authors: Dickson Kofi Wiredu Ocansey, Li Wang, Jingyan Wang, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu and Fei Mao Tags: Review Source Type: research

The dual functional role of MicroRNA-18a (miR-18a) in cancer development
The polycistronic miR-17-92 cluster is instrumental in physiological processes commonly dysregulated in cancer, such as proliferation, the cell cycle, apoptosis, and differentiation. MicroRNA-18a (miR-18a) is ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 23, 2019 Category: Internal Medicine Authors: Kexin Shen, Zhe Cao, Ruizhe Zhu, Lei You and Taiping Zhang Tags: Review Source Type: research

Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population-based study of 16,643 patients
Bone is a preferential site for prostate cancer (PCa) metastasis. However, sites of synchronous distant metastases in PCa patients with bone metastases at initial diagnosis and their impacts on prognosis are s... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 29, 2019 Category: Internal Medicine Authors: Feng Zhao, Jili Wang, Meiqin Chen, Danni Chen, Sunyi Ye, Xinke Li, Xin Chen, Guoping Ren and Senxiang Yan Tags: Research Source Type: research

Rethinking the combination treatment of fulvestrant and anastrozole for metastatic breast cancer: an integrated reanalysis of aromatase –estrogen receptor axis
Aberrant expression or hyperactivation of aromatase (CYP19A1) –estrogen receptor (ESR) axis is well identified as one of the major causes of breast cancer. Lots of drugs have been developed for targeting CYP19A... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 18, 2019 Category: Internal Medicine Authors: Xing Huang Tags: Commentary Source Type: research

Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSC), the most common ovarian carcinoma type, is associated with the highest mortality rate among all gynecological malignancies. As chemoresistance has been demonstrated as ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 29, 2019 Category: Internal Medicine Authors: Xin Qi, Chunjiang Yu, Yi Wang, Yuxin Lin and Bairong Shen Tags: Research Source Type: research

From fiction to science: clinical potentials and regulatory considerations of gene editing
Gene editing technologies such as CRISPR/Cas9 have emerged as an attractive tool not only for scientific research but also for the development of medicinal products. Their ability to induce precise double stra... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 21, 2019 Category: Internal Medicine Authors: Maria Schacker and Diane Seimetz Tags: Review Source Type: research

Debutant iOS app and gene-disease complexities in clinical genomics and precision medicine
The last decade has seen a dramatic increase in the availability of scientific data, where human-related biological databases have grown not only in count but also in volume, posing unprecedented challenges in... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 4, 2019 Category: Internal Medicine Authors: Zeeshan Ahmed, Saman Zeeshan, Ruoyun Xiong and Bruce T. Liang Tags: Short report Source Type: research

Mesenchymal stem cells-derived extracellular vesicles in acute respiratory distress syndrome: a review of current literature and potential future treatment options
Acute respiratory distress syndrome (ARDS) is a life-threatening inflammatory lung condition associated with significant morbidity and mortality. Unfortunately, the current treatment for this disease is mainly... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 12, 2019 Category: Internal Medicine Authors: Trushil G. Shah, Dan Predescu and Sanda Predescu Tags: Review Source Type: research