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Phosgene-induced acute lung injury (ALI): differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine
Phosgene (carbonyl dichloride) gas is an indispensable chemical inter-mediate used in numerous industrial processes. There is no clear consensus as to its time- and inhaled-dose-dependent etiopathologies and a... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 2, 2017 Category: Internal Medicine Authors: Wenli Li and Juergen Pauluhn Source Type: research

Can glypican-3 be a disease-specific biomarker?
Glypican-3 (GPC3) is a cell surface-bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory distress... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 16, 2017 Category: Internal Medicine Authors: Chaolei Chen, Xiaomin Huang, Zhaojian Ying, Dengmin Wu, Yani Yu, Xiangdong Wang and Chengshui Chen Source Type: research

Anthracycline induced cardiotoxicity: biomarkers and “Omics” technology in the era of patient specific care
Anthracyclines are highly effective against a variety of malignancies. However, their dose-dependent cardiotoxic effects can potentially limit their use. In the past decade, serum biomarkers have been used to ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 10, 2017 Category: Internal Medicine Authors: Shayan Moazeni, Martin Cadeiras, Eric H. Yang, Mario C. Deng and Kim-Lien Nguyen Source Type: research

ETS-targeted therapy: can it substitute for MEK inhibitors?
The RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues. In clinical practice and clinical trials, sm... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 2, 2017 Category: Internal Medicine Authors: Osamu Tetsu and Frank McCormick Source Type: research

Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway
Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated re... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 12, 2017 Category: Internal Medicine Authors: Yves Lecarpentier, Victor Claes, Alexandre Vall ée and Jean-Louis Hébert Source Type: research

Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis
Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 12, 2017 Category: Internal Medicine Authors: Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong and Rachel E. Ellsworth Source Type: research

Lessons from the swamp: developing small molecules that confer salamander muscle cellularization in mammals
The ability of salamanders, such as newts, to regenerate damaged tissues has been studied for centuries. A prominent example of this regenerative power is the ability to re-grow entire amputated limbs. One imp... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 22, 2017 Category: Internal Medicine Authors: JungIn Um, Da-Woon Jung and Darren Reece Williams Source Type: research

Translational research in pediatric pulmonary disease, 2017
As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatr... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 1, 2017 Category: Internal Medicine Authors: Bruce K. Rubin Source Type: research

Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs
Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation. (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 1, 2017 Category: Internal Medicine Authors: George E. Naoum, Zeng B. Zhu, Donald J. Buchsbaum, David T. Curiel and Waleed O. Arafat Source Type: research

Single cell sequencing: a distinct new field
Single cell sequencing (SCS) has become a new approach to study biological heterogeneity. The advancement in technologies for single cell isolation, amplification of genome/transcriptome and next-generation se... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 20, 2017 Category: Internal Medicine Authors: Jian Wang and Yuanlin Song Source Type: research

Integrating phosphoproteomics into the clinical management of prostate cancer
Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcrip... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 14, 2017 Category: Internal Medicine Authors: Larry C. Cheng, Victor M. Tan, Shridar Ganesan and Justin M. Drake Source Type: research