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Re: Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer 

(Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 7, 2017 Category: Internal Medicine Authors: Michael McKay Source Type: research

Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer
Immune checkpoint blockade therapy by targeting the programmed death protein 1/programmed death ligand 1 (PD-L1) axis using antibodies has yielded promising clinical responses in patients with non-small cell l... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 20, 2017 Category: Internal Medicine Authors: Xiaoming Liu and William C. Cho Source Type: research

The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes
The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 18, 2017 Category: Internal Medicine Authors: Brian M. Necela, Bianca C. Axenfeld, Daniel J. Serie, Jennifer M. Kachergus, Edith A. Perez, E. Aubrey Thompson and Nadine Norton Source Type: research

Tissue is the issue and tissue competition. Re-biopsy for mutation T790: where and why?
Lung cancer is still the leading cause of death among all cancers. During the last 15  years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epiderm... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 18, 2017 Category: Internal Medicine Authors: Paul Zarogoulidis, Mina Gaga, Haidong Huang, Kaid Darwiche, Aggeliki Rapti and Wolfgang Hohenforst-Schmidt Source Type: research

Contact allergy to aluminium induced by commonly used pediatric vaccines
(Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 4, 2017 Category: Internal Medicine Authors: E. Bergfors, B. Trollfors, A. Inerot and A. Gente Lidholm Source Type: research

A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet
Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting effects, and demonstrated improved overall survival and tolerance, when compared to patients treated with conventional ch... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 3, 2017 Category: Internal Medicine Authors: Gabriele D ’Errico, Heather L. Machado and Bruno Sainz Source Type: research

A systematic approach to cancer: evolution beyond selection
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 3, 2017 Category: Internal Medicine Authors: William B. Miller and John S. Torday Source Type: research

MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO)
This study aims to develop targeted superparamagnetic particles of iron ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 2, 2017 Category: Internal Medicine Authors: Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo Source Type: research

Clinical protein science developments for patient monitoring in hospital central laboratories
Patient care relies heavily on standardized tests performed in hospital laboratories, typically including clinical chemistry, pathology and microbiology. With the introduction of personalized medicine tremendo... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 19, 2016 Category: Internal Medicine Authors: Johan Malm and Gy örgy Marko-Varga Source Type: research

Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer
The genome is under constant assault from a multitude of sources that can lead to the formation of DNA double-stand breaks (DSBs). DSBs are cytotoxic lesions, which if left unrepaired could lead to genomic ins... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 5, 2016 Category: Internal Medicine Authors: Sonali Bhattacharjee and Saikat Nandi Source Type: research

Safety concerns and hidden agenda behind HPV vaccines: another generation of drug-dependent society?
Analyses of data and hidden agenda behind repeated failed outcomes of cancer research and therapy, status of American health, safety concerns for HPV vaccines and future research considerations are summarized ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 5, 2016 Category: Internal Medicine Authors: Mahin Khatami Source Type: research

Novel paradigm for immunotherapy of ovarian cancer by engaging prophylactic immunity against hepatitis B virus
Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10  years. First line therapies: surgery, chemotherapy, and radiation therapy in... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 30, 2016 Category: Internal Medicine Authors: Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan Source Type: research

Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases
We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 20, 2016 Category: Internal Medicine Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian Source Type: research

A braided cancer river connects tumor heterogeneity and precision medicine
With the ever-increasing complexity of tumor heterogeneity (TH) discovered through cancer genome sequencing, it is apparent that TH has become the biggest hurdle for precision cancer therapeutics. Through stud... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 20, 2016 Category: Internal Medicine Authors: James J. Hsieh and Emily H. Cheng Source Type: research

Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation
The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 20, 2016 Category: Internal Medicine Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam Source Type: research